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Presenters: Solomon N
Liyew A
Modulated by: Dr. Tizazu(MD, Obstetrician and Gynecologist)
OUT LINES
īƒ˜Introduction
īƒ˜Definition
īƒ˜Objectives of FP
īƒ˜Classifications of FP methods
īƒ˜NFP methods
īƒ˜Barrier methods
īƒ˜IUCD
īƒ˜Hormonal methods
īƒ˜Permanent methods
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INTRODUCTION
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CONT. â€Ļ
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CONT. â€Ļ
ī‚— Rapid population growth (96% in developing
countries) is a critical issue worldwide.
ī‚— Family planning matters save women’s lives
preventing unintended pregnancies.
ī‚— Slower population growth, conserves
resources, improves health and living
standards.
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DEFINITION
ī‚— Having the number of children you want when you
want them.
It is not to control births, but to plan pregnancies
but birth control includes abortion to prevent a
birthâ€Ļwhere as FP as defined by UN & WHO
encompasses service leading upto conception and
does not promote abortion as a FP method.
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CONT. â€Ļ
ī‚— Contraception and fertility control are not
synonymous.
ī‚— Fertility control includes both fertility inhibition
(contraception) and fertility stimulation
ī‚— While the fertility stimulation is related to the problem
of the infertile couples,
ī‚— The term contraception includes all measures,
temporary or permanent, designed to prevent Px due to
the coital act.
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Family planning is:
1. Having the number of children based on the
couple’s belief, health and economic situation.
2. Spacing births properly.
3. Making sure pregnancies occur only during the
right time in a mother’s life.
4. Helping childless couples have children
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Objectives of FP
īļ To avoid unwanted pregnancies.
īļ To bring about wanted births.
īļ To regulate the intervals between pregnancies.
īļ To control the time at which births occur in relation to
the ages of the parent ; and
īļ To determine the number of children in the family.
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ī‚— Ideal contraceptive methods should be:
īƒ˜widely acceptable,
īƒ˜inexpensive,
īƒ˜simple to use,
īƒ˜safe,
īƒ˜highly effective and
īƒ˜requiring minimal motivation, maintenance and
supervision.
ī‚— So far there is no universally acceptable ideal method.
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Contraceptive efficiency:
īƒ˜It is the measurement of unplanned pregnancies even
after the use of contraceptive measures in the presence of
factors affecting.
īƒ˜can be measured by the pearl index.
īƒ˜ Pearl Index: no. Of failures/100 woman-years of exposure
īƒ˜Failure rate = Total accidental pregnancies × 1200
Total months of exposure
1200=12 months per 100 women
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Health Rationale
ī‚— Saves women’s lives and improves their health
ī‚— Spaces pregnancies, which saves children’s lives
and improves their health
ī‚— Benefits couple, family and community
ī‚— Helps adolescents make responsible choices
ī‚— Allows men to share responsibility for reproductive
health and child rearing
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Benefits of family planning
1. For the Mothers
īƒ˜Protection from early and unwanted pregnancy
īƒ˜Prevention of unsafe abortions
īƒ˜Protection from STDs
īƒ˜Increased education opportunities
īƒ˜Increased job possibilities
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Cont. â€Ļ
2. For the Children
īƒ˜Better health
īƒ˜More food and resources available
īƒ˜Greater opportunity for emotional support from
parents
īƒ˜Better opportunity for education
3. For the Fathers:
īƒ˜Protection from STDs
īƒ˜Less emotional and economic strain
īƒ˜Improved quality of life
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Cont. â€Ļ
4. For the community
īƒ˜ Reduced strain on environmental resources (land, food,
water)
īƒ˜ Reduced strain on community resources (healthcare,
educational and social services)
īƒ˜ Greater participation by individuals in community
affairs
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Choosing a method
Choosing a method depends on:
Efficacy
Convenience
Duration of action
Reversibility and time to return of fertility
Effect on uterine bleeding
Frequency of side effects and adverse events
Affordability
Protection against sexually transmitted diseases
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Medical Eligibility Criteria for
Contraceptive Use, WHO
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No restriction of method use
Method advantages outweigh risks
Method poses an unacceptably high
Health risk 3/22/2021
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TYPES OF CONTRACEPTION
Hormonal Combined hormonal contraception
Progestogen-only contraception
Emergency hormonal contraception
Non
hormonal
Traditional methods
Barrier methods
Intra-uterine devices
Sterilization: male and female
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CONTRACEPTIVE
METHODS
NATURAL ARTIFICIAL
PERMANENT
TEMPORARY
BTL
VASECTOMY
BARRIER
IUCD (copper T)
HORMONAL
ABSTINENCE
WITHDRAWAL
SDM
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Classification
Natural FP Methods
ī‚§ Calendar Rhythm
ī‚§ Cervical mucus (billings)
ī‚§ Basal Body Temperature
ī‚§ Sympto-thermal
ī‚§ Lactation Amenorrhea
ī‚§ Coitus interruptus (withdrawal)
ī‚§ Abstinence
Hormonal methods
– OCP (COC, POCP)
– Hormone bearing IUDs
– Injectables
– Implants
– Contraceptive Skin patches
– Vaginal rings
Intrauterine devices
– Inert forms
– Copper bearing
– Hormone bearing
Barrier methods
Condom(Male, Female)
Spermicides
Cervical caps
Diaphragm
Permanent methods
– Vasectomy
– BTL
Emergency Contraception
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A . Abstinence
īƒ˜Delay sexual activity until financially, emotionally, and
physically ready for the responsibilities of childbearing.
īƒ˜The only method that is 100% effective.
Advantages
īƒ˜It protects you from STDs and pregnancy.
Disadvantages
īƒ˜Coping with peer pressure
īƒ˜Motivation is essential
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NATURAL FAMILY PLANNING
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B. Post-coital Douching
ī‚— Involves washing the vagina by spraying a cleaning
solution into the vagina after intercourse
ī‚— Ineffective and unreliable method
ī‚— Disadvantages
Pushes sperm deeper into the vagina increasing the risk of
pregnancy
Increases the risk of PID
Increases the risk of ectopic pregnancy
Increases the risk of vaginal yeast infections
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C. Lactational Amenorrhea Method (LAM)
īƒ˜Based on scientific evidence that a woman is not fertile and
unlikely to become pregnant during full lactation or
exclusive breastfeeding (Ovulation is suppressed during
lactation).
īƒ˜Breastfeeding with no supplemental feeding of any type is
given (not even water) and the infant is feeding both(6 hrs)
day and night(4hrs) with little separation from the mother.
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Irregular secretion of GnRH interferes
with release of follicle stimulating
hormone (FSH) and leutinizing
hormone (LH)
Frequent intense suckling disrupts
secretion of Gonadotrophin releasing
hormone (GnRH)
Decreased FSH and LH
disrupts follicular
development in the ovary to
suppress ovulation
LAM: Mechanisms of Action
β -Endorphins induced by suckling also induce a
decline in the secretion of dopamine, which normally
suppresses the release of prolactin. This results in a
condition of amenorrhea and anovulation
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Cont. â€Ļ
It provides maximum protection as long as:
ī‚— The woman is less than six months postpartum
ī‚— She is breastfeeding exclusively
ī‚— She is amenorrheic
NB. If these conditions are not met, the risk of
unintended pregnancy while breastfeeding is high.
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Cont. â€Ļ
īą Use of COCs generally is not advised during
lactation because they reduce the amount and
quality of breast milk.
īąCan be used after 6 weeks, once milk production is
established.
īąProgestin-only OCs, implants, and injectable
contraception do not affect milk quality or
quantity
Adv. Free and easily available, decrease breast ca
Disadv. Px occur
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D. Coitus interrupts (withdrawal) method
ī‚— Involves removing the penis before ejaculation
ī‚— Objective is to keep the sperm from entering the vagina
Adv.
Free
Dis adv.
Pregnancy could occurme contains sperm cells
Depends on male control
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E. Rhythm method
īƒ˜ Also called Periodic abstinence or natural contraception.
īƒ˜ Relies on abstinence from sexual intercourse during the most
fertile phase of a woman’s menstrual cycle.
īƒ˜ It needs identification of the fertile (unsafe) and
infertile(safe) phases of the menstrual cycle
īƒ˜ Fertilization takes place within the tube, and the ovum remains
in the tube for approximately 1–3 days after ovulation;
īƒ˜ from the time of ovulation to 2–3 days thereafter;
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Cont. â€Ļ
Various methods are used;
īąCalendar method
īąBasal Body Temperature
īąCervical Mucus(billings) method
īąSympto-Thermal Methods
īą The combined temp and calendar method
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1. Calendar method
īƒ˜Requires recording the length of 12 consecutive menstrual
cycles.
Calculation:
1st day of fertile period = shortest cycle-18 days
Last day of fertile period = longest cycle-11 days
īƒ˜Sexual intercourse is abstained b/n these days
īƒ˜User effectiveness is 20-30/100 women-years
Adv. No side effects or health issues
Completely natural and free
Drawbacks: Only for educated and responsible couples
High Failure rate
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2. Basal Body Temperature
īƒ˜more reliable evidence of ovulation
īƒ˜Is based on Temp. changes
īƒ˜A rise of 0.4 - 0.8 °C above the mean Temp. of the
pre-ovulatory phase for 3 days indicates ovulation has
occurred.
īƒ˜Abstinence is required from the time of menses until
3 days after the rise in temperature.
īƒ˜ True basal temperatures are recorded, i.e, fever due
to other causes??
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3. Cervical Mucus(billings) method
ī‚— Also called the ovulation method
ī‚— Women takes sample of her mucus everyday for a month
ī‚— Under estrogen influence, the mucus increases in quantity
and more slippery and elastic until a peak day is reached.
ī‚— Scanty and dry under the influence of progesterone
ī‚— Women should avoid unprotected sex from the days
secretions start until four days after the peak day.
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35
Cervical Mucus Cycle
Beginning Peak End
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Cont. â€Ļ
ī‚— Adv.
Free
Can be stopped at any time
Helps women to be aware of their cycle
ī‚— Dis adv.
Failure rate is 20% per year
Requires effort and work
Because sperm may survive 5 to 7 days in the female genital tract
īƒ˜User effectiveness is 15-20/100 women years
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4. Sympto-Thermal Methods
â€ĸ If used properly, probably is the most effective of all the
periodic abstinence approaches.
â€ĸ It combines the cervical mucus and the temp methods.
â€ĸ In addition, symptoms that may occur just prior to
ovulation,- bloating , slight cramping and breast tenderness, are
used as adjuncts
5. The combined temp and calendar method;
ī‚— Failure rates of only 5 px/ 100 women year
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Barrier methods
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Physicalmethods
1. condoms :
A. Male condom
ī‚— Made up of fine latex sheath
ī‚— Most widely used barrier in males
ī‚— Highly effective if used correctly
Failure rate: 2-3 %â€Ļ
mainly due to improper and inconsistent use
Advantage:
ī‚— Simple spacing method
ī‚— No side effects
ī‚— Easily available, safe & inexpensive
ī‚— Protects against STD
ī‚— Also protection from cervical Neoplasia
Disadvantage:
ī‚— Chances of slip off and tear off
ī‚— Some men are allergic to latex
ī‚— Those with spermicide may cause irritation
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B. Female condom
īƒ˜Strong, soft, transparent vaginal pouch made of polyurethane sheath
īƒ˜ Inserted before sexual intercourse
īƒ˜Has two flexible rings
īļ The outer ringâ€Ļthe larger, open ring stays outside the
vagina,
īļ The inner ring â€Ļat the closed end of the condom eases
insertion into the vagina, covering the cervix and holding
the condom in place
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Cont. â€Ļ
ī‚§ Breakage, less and slippage more, than male condom
ī‚§ Inserted for up to 8 hours
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Adv
Stronger
Offers greater protection
No side effects of hormone
Prevention stds
Dis adv.
Allergy
Tear or damage unnoticed
Difficulties in insertion and
removal
More expensive
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2. diaphragm
ī‚— A mechanical barrier between the
vagina and the cervical canal..
īļProper fitting is key
īļA contraceptive jelly or cream
should be placed on the cervical side
before insertion.
ī‚— 6 hrs prior to intercourse & left
in place for 6–8 hrs after.
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Cont. â€Ļ
ī‚— Pearl index 10–20
īą If intercourse is repeated, additional spermicidal
inserted into the vagina without removing the
diaphragm.
īą It is then removed, washed with soap, dry, and store away
from heat.
īą not be dusted with talc powder
Adv- Some protection against STD and reused – 1 yrs.
Dis adv;
ī‚— Vaginal wall irritation
ī‚— Risk of UTI
ī‚— Requiring fitting by a physician or a trained
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3. Cervical cap
ī‚— Is a rubber cup with metallic rim designed to fit the cervix
ī‚— smaller as compared to diaphragm
ī‚— Used with a spermicide
ī‚— Applied over cervix before intercourse
ī‚— left in place for 8–48 hours after intercourse
ī‚§ Pearl Index 11 – 19 %
Dis adv.
difficulty in placing
displacement high
Cervicitis and local irritation
a foul discharge if >1 day of use
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Chemical barriers
ī‚— Spermicidal agents which can destroy sperms
when applied in female genital tract 10-15
min before each sexual act
ī‚— used alone or in conjunction with a
diaphragm , cervical cup or condom.
ī‚— Various preparations as
1) Foams
2) Creams. Jellies, Paste
3) Suppositories
4) Soluble films
Adv:
Inexpensive
Well tolerated
Good protection
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Intrauterine contraceptive device
(IUD)
Two types of IUD :
1. Copper T 380A (Paragard)
2. Levonorgestrel releasing IUD- Mirena, Skyla and Liletta
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Proper placement of cu T
380A
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Description of IUD’s
i. Cu T 380A: carries 380 mm2 area of
copper wire wound around the vertical &
horizontal arms. It is removed every 10
years
ii. Multiload Cu375: it has 375 mm2 of
copper wire. It is removed every 5 years
iii. Multiload Cu250: No introducer &
plunger and removed every 3 years.
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Mechanism of Action
Family planning
ī‚— Intense local endometrial inflammatory response
is induced, by copper-containing devices.
ī‚— Lead to decreased sperm and egg viability.
ī‚— The progestin renders the endometrium atrophic
ī‚— Impaired sperm ascent
ī‚— Prevent implantation
ī‚— Thick cervical mucus,
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Levonorgestrel Intrauterine system:>99%
ī‚§ There are Three different levonorgestrel-releasing
intrauterine systems-IUD- Mirena, Skyla and Liletta
ī‚§ Their T-shaped radiopaque frames have a stem
wrapped with a cylinder reservoir that contains the
levonorgestrel.
ī‚§ The cylinder has a permeable membrane that
regulates continuous daily hormone release
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Cont. â€Ļ
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a. Mirena
īƒ˜ For 5-7 years
īƒ˜ Initial levonorgestrel
release rate is 20
mcg/day; rate reduced
by 50% after 5 years
īƒ˜ Follow up 4-12 weeks
after insertion
b. Skyla and liletta
īƒ˜ For 3 years
īƒ˜ Levonorgestrel release
rate is 14 mcg/day and 5
mcg/day after 3 years
īƒ˜ Follow up 4-6 weeks
after insertion
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Cont. â€Ļ
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Initiation: within 7 days after menstrual period
begins /Immediately to 2 wks following abortion/
Side effects:
īƒŧ Mal positioning of the device
īƒŧPain or bleeding
īƒŧIrregular spotting for up to 6 mths after insertion
and there after to expect monthly menses to be
lighter or even absent /progressive amenorrhea/.
īƒŧCycles may be even heaver than the normal/
Menorrhagia, Anemia/
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Cont. â€Ļ
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Fertility issues:
īƒ˜ endometrium recovers quickly, normal
ovulations are established and the fertility
seems to be unaffected after use of an LNG-
IUD.
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Cont. â€Ļ
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Complications
Immediate:
Cramp like pain
Partial or complete perforation
Remote:
Pain
AUB
Pelvic infection
Spontaneous expulsion
Perforation of the uterus
Pregnancy
Missing thread
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Indications for removal of IUDs
1. Persistent menstrual problems
2. Tube -ovarian abscess
3. Perforation of the uterus
4. Partial expulsion
5. Pregnancy with IUD
6. Desiring fertility/ planning pregnancy
7. Missing thread
8. One year after menopause
9. Effective life span is over
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contraindications
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HORMONAL CONTRACEPTION
īļIt is classified in to two
īļHCPs are one of the most widely used world
wide;
CHCs
POPs
īļ They are available in the form of pill, injectable,
implant
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Composition Route Duration
-CHC (E + P) -Oral(COC, POP, Emergency -Long acting
(L, E+L) ) (LNIURS, implants)
-short acting
-Progesterone only -injectable (MPA) (others)
-implant (levonor)
-IUD (LNIURS)
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Classifications of Hormonal Contraceptives
Reversible
īƒŧCHC
īƒŧPOP
īƒŧDMPA
īƒŧImplants
īƒŧLNRIUS
īƒŧ CU-IUD
Permanent
īƒ˜Sterilization
īƒŧMale
īƒŧfemale
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Classifications of hormonal Contraceptivesâ€Ļ.
(According to (CDC)),
Cont. â€Ļ
It is a combination of two steroids hormones
īļThese are:-
īƒŧEstrogen
īƒŧProgesterone
īļ It is given for 21 days and 7 free day period.
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Estrogen Progestin
Monophasic EE 35 mcg Norethindrone 0.5mg
Biphasic EE 35 mcg Norethindrone 0.5mg
EE 35 mcg Norethindrone 1 mg
Triphasic EE 30 mcg Levonorgestrel 0.05 mg
EE 40 mcg Levonorgestrel 0.075 mg
EE 30 mcg Levonorgestrel 0.125 mg
Types of preparation
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BIPHASICS AND TRIPHASICS
īļMultiphasic pills were developed to reduce
the amount o total progestin per cycle
without sacrifcing contraceptive effcacy or
cycle control.
īļUseful when there is breakthrough bleeding.
īąAdv
īļ Tend to give a more natural bleeding pattern
īļ Iimitate the normal menstrual cycle & hormonal
fluctuations more closely than monophasics
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Mechanisms of Action
Suppress ovulation
Change endometrium making
implantation less likely
Thicken cervical mucus
(preventing sperm
penetration)
Reduce sperm transport
in upper genital tract
(fallopian tubes)
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Disadvantage and Side effects
īƒ˜ User dependent( require continued motivation and
daily use)
īƒ˜ Effectiveness may be lowered by certain
drugs
īƒ˜ Forgetfulness increase the failure
īƒ˜Does not protect against STIs
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Cont. â€Ļ
CARDIO VASCULAR SYSTEM
Thrombo embolic disease
Ischemic heart disease especially in predisposed
CENTRAL NERVOUS SYSTEM
STROKE
Liver
slight transient impairment of liver function
cholestasis
increased incidence of gallstone( associated
with high biliary cholesterol secretion).
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Cont. â€Ļ
Carbohydrate metabolism
â€ĸ Impairment in glucose metabolism, especialy in predisposed.
â€ĸ Diabetes if present become more difficult to control( b/c of
effect in liver metabolism and progesterone insulin
antagonism effect.
Lactation-decrease milk production .
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Contiâ€Ļ
ī‚§ Nausea and vomiting
ī‚§ headache ,irritability and depression
ī‚§ Breast engorgement, tenderness& enlargement
ī‚§ Skin pigmentation
Menstrual disturbance
ī‚§ Spotting
ī‚§ Break though bleeding
ī‚§ Amenorrhea
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Contraindication
ī‚— Hypertension
ī‚— Some known hyperlipedimia
ī‚— Smoking ,<15cigrret/day
ī‚— age â‰Ĩ35
ī‚— Obesity and migraine
ī‚— Current or treated gall bladder disease
ī‚— History of choliostasis
ī‚— Mild cirrhosis
ī‚— Rifampicin and anti convelsant drugs
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Cont. â€Ļ
īļ Absolute
â€ĸ Breast feeding <6 month of post partum
â€ĸ Multiple cardiovascular risk factor
â€ĸ HTN >160/110 mmhg
â€ĸ Current problem of venous thrombo embolism
â€ĸ Major surgery with prolonged immobilization
â€ĸ Current ischemic heart disease and stroke
â€ĸ DM with vascular complication
â€ĸ Sever cirrhosis
â€ĸ Women over age 35 years who smoke
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Indications for withdrawal in COC
īƒŧ With Sx/Sn that indicate major side effect.
īƒŧ Elective surgery:- 4weeks before, but if emergency
use heparin.
īƒŧ Visual disturbances
īƒŧ Sudden chest pain with DVT
īƒŧ Severe cramp & pains in leg
īƒŧ Severe depression
īƒŧ when pregnancy is needed
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PROGESTRON ONLY PILLS
īļ Contain only progestin derivatives
īļ It avoid side effect of estrogen
īļ It is prepared in the form oral, injectable and
implant.
.
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Cont. â€Ļ
īļThe commonly used progestin are:
īƒ˜levonogestrel 75 g
īƒ˜norethisteron 350 g
īƒ˜ethinodiol di acetate 500 g
īƒ˜desogestrel 75 g
īƒ˜lynestrol 500 g
īƒ˜norgestrel 30 g.
īļThey have to be taken with no hormone free
interval
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Mechanism of action
73
1. Thicken cervical mucus ,preventing sperm
penetration
2. Suppress ovulation
3. Makes the endometrial less favorable for
penetration.
4. Reduce sperm transport in upper genital
tract(fallopian tube)
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Cont. â€Ļ
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īļ If a woman using a POP misses her dose by
more than three hours it is quite likely that
she is not protected.
Advantages:
ī‚— Side effects of estrogen will be eliminated
ī‚— No adverse effect on lactation
ī‚— No “on & off” regimen during taking
ī‚— Can be used in Hypertensive pts.
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Cont. â€Ļ
Adv.
ī‚§ Precise timing, failurity
ī‚§ Acne
ī‚§ Changes in menstrual pattern(irregular bleeding/spotting
initially )
Contra
â€ĸ Pregnancy
â€ĸ Known or suspected cancer reproductive tract and breast
â€ĸ Undiagnosed genital tract bleeding
â€ĸ Taking drug like rifampicin, phentoyin,and barbiturates ???
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Injectable steroids
1. DMPA (Depo-Proveraīƒ’.
medroxyprogesterone acetate )
ī‚— 150 mg IM every 3 months.
ī‚— It is most effective contraceptive method with
failure rate of 0.3%
s/e-
– Slow return to fertility
– Irregular bleeding
– WT gain
– Amenoria
– Short-term loss of bone mineral density/ Osteoclasts/
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ī‚— Implant system(1, 2, 6 rods)
ī‚— >99%: thin, pliable progestin-containing
cylinders that are implanted subdermally and
release hormone over many years.
.
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Contraceptive implant
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Implant systems: after removal fertility comes immediately.
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Cont. â€Ļ
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Cont. â€Ļ
Implanon
īļ Single rod containing
Etonogestrel
- Subdermally (medial
surface of the upper
arm 8 to 10 cm from
the elbow)
- every 3 yrs
- 68 mg
- Efficacy is extremely
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Cont. â€Ļ
2) Norplant:
ī‚— six rod for five years with each rod
containing 38 mg of levonorgestrel
releasing initially 85ug/day and later
30ug/day over five years.
80
3/22/2021
Family planning
Implant
3) Jadelle ÂŽ
ī‚— 2 rods
ī‚— Effective 5 years
ī‚— 1-yr failure: 0.05% (1 in 20,000); 5-yr
failure 1.1%
4) Sinoplant – 2 rod used for 4 years
81
3/22/2021
Family planning
Mechanism of Action
ī‚— Suppresses ovulation
ī‚— Increases cervical mucus viscosity
ī‚— Alters endometrium
82
3/22/2021
Family planning
Features of Implants
â€ĸ Highly effective
â€ĸ Can be used during lactation
â€ĸ Rapidly reversible
â€ĸ Contain no estrogen
â€ĸ Safe
3/22/2021
Family planning
83
Side effects:
īļmalpositioning of rods during placement.
ī‚— Can cause irregular bleeding
ī‚— Requires clinician visits for insertion and
removal
ī‚— Does not protect from STDs
84
Cont. â€Ļ
3/22/2021
Family planning
Cont. â€Ļ
85
Adv;
â€ĸ Long term use
â€ĸ Immediate return of fertility on removal
Dis adv;
â€ĸ Requires trained provider for insertion and
Removal
â€ĸ Women cannot stop whenever they want.
â€ĸ Infection at insertion site.
3/22/2021
Family planning
EMERGENCY HORMONAL
CONTRACEPTION
Any woman of reproductive age may need at
some point to avoid unwanted pregnancy,
following situations such as:
īļ After unprotected sexual intercourse
īļAfter incorrect use of regular contraceptive
methods
īļ Sexual assault
86
3/22/2021
Family planning
Cont. â€Ļ
ī‚— Condom breakage or slippage.
ī‚— Miscalculation of the infertile period when using
periodic abstinence
ī‚— failure to abstain from sexual intercourse during
the fertile days.
ī‚— Expulsion of an IUD.
87
3/22/2021
Family planning
Cont. â€Ļ
88
3/22/2021
Family planning
Cont. â€Ļ
The standard regimen consists of the “combined”
oral pills. This regimen is known as the “Yuzpe
method”
īąHigh-dose pills containing 50 ug of
ethinylestradiol and 250 ug levonorgestrel (or 500
ug dl-norgestrel)
īļ Two pills should be taken as the first dose as
soon as convenient but no later than 72 hours
after unprotected intercourse. These should be
followed by two other pills 12 hours later.
89
3/22/2021
Family planning
Cont. â€Ļ
īąlow-dose pills containing 30ug ethinylestradiol and
150uglevonorgestrel (or 300 ug dl-norgestrel)
īļ Four pills should be taken as the first dose as
soon as convenient but no later than 72 hours
after unprotected intercourse. These should be
followed by another four pills 12 hours later.
90
3/22/2021
Family planning
Cont. â€Ļ
īąlevonorgestrel-only pills (post pill) containing
750ug(0.75mg) levonorgestrel
īļ One pill should be taken as the first dose
as soon as convenient but no later than 72
hours after unprotected intercourse. This
should be followed by another pill 12 hours
later.
91
3/22/2021
Family planning
3. Copper-containing IUDs (CU T 380 A)- >99%
This can be used up to five days after unprotected
intercourse.
MOA-
īƒŧ interference with fertilization
īƒŧ prevent implantation of a fertilized egg
S/e- Nausea, Vomiting, Breast tenderness, Headache,
menstrual disturbance & Ectopic pregnacy
92
Cont. â€Ļ
3/22/2021
Family planning
Trials â€Ļ
ī‚§ Hormonal male contraception clinical trials began
in the 1970s.
ī‚§ The method is based on the use of exogenous
testosterone alone or in combination with a
progestin to suppress the endogenous production
of testosterone and spermatogenesis.
ī‚§ Studies using testosterone alone showed that the
method was very effective with few adverse
effects.
3/22/2021
Family planning
93
Male Hormonal Contraceptive â€Ļ
the new era
ī‚§ Addition of a progestin increases the rate and extent
of suppression of spermatogenesis (decrease sperm
count).
ī‚§ Common adverse effects include acne, injection site
pain, mood change including depression, and
changes in libido.
ī‚§ Current development includes long-acting injectables
and transdermal gels and novel androgens that may
have both androgenic and progestational activities.
3/22/2021
Family planning
94
Male Hormonal Contraceptive â€Ļ
the new era
3/22/2021
Family planning
95
Male Hormonal Contraceptive â€Ļ
the new eraâ€Ļ MOA
īļ Men were given progestogen (NET-EN, 200mg)
and testosterone injections (TU,1000mg) into the
buttock muscles at the beginning of the study and
then at 8, 16 and 24 weeks. (peer reviewed Journal
of Endocrinology and metabolism)- involving 320
men
īƒŧ Effectiveness- 98.4%
īƒŧ Acne- 49.9%
īƒŧ Mood disorder- 0.016%
īƒŧ did not recover their sperm count one year after stopping
the injections- 5% ??????
96
Male Hormonal Contraceptive â€Ļ
the new era
3/22/2021
Family planning
Terminal methods
ī‚¨ A surgical method where by the reproductive
function of an individual male or female is
purposefully & permanently destroyed
ī‚¨ Vasectomy in male and tubal occlusion in female
ī‚¨ Couple need to be adequately informed before
any permanent procedure
97
3/22/2021
Family planning
Vasectomy
ī‚¨ Segment of vas deferens of both sides are
resected and cut ends are ligated
ī‚¨ Advantages:
1. Simple
2. Failure rate is low (0.15%)
3. Minimal expenditures
98
3/22/2021
Family planning
Vasectomyâ€Ļ
ī‚¨ Drawbacks:
1. Additional contraceptive needed for the first 2-
3 months
2. Psychological Fair of impotence
ī‚¨ Candidates:
1. Sexually active, psychological prepared &
completed fertility
2. No eczema or scabies around scrotal region
3. Correct hernia &/or hydrocele before
vasectomy
99
3/22/2021
Family planning
complications
ī‚¨ Immediate:
1. Wound infection and sepsis
2. Scrotal hematoma
ī‚¨ Remote:
1. Spontaneous recanalization
100
3/22/2021
Family planning
Female sterilisation
ī‚¨ Most popular method of terminal
contraception world wide
ī‚¨ Occlusion of both fallopian tubes
â€ĸ Tubal ligation
â€ĸ Bilaterally
â€ĸ The most common surgical sterilization
procedure for women
101
3/22/2021
Family planning
Cont. â€Ļ
102
â€ĸ the fallopian tubes are either cut and separated
or they are sealed shut.
â€ĸ This prevents the egg and sperm from meeting
and thus prevents pregnancy
ī‚¨ Indications:
1. Family planning purposes
2. After having the desired number of children
3. Medico-surgical indications (therapeutic)
3/22/2021
Family planning
Cont. â€Ļ
â€ĸ The procedure can be performed
īŽ postpartum (within 48 hours post-vaginal
delivery),
īŽ at the time of cesarean delivery,
īŽ interval or concurrent medical termination
īŽ as an interval procedure (>6 weeks
postpartum) via laparoscopy or mini-
laparotomy (rarer).
ī‚¨ Ligation could be abdominal,or laparascopic
ī‚¨ Different surgical types
103
3/22/2021
Family planning
Effects of Sterilization
īą Benefits
ī‚§ Effects are immediate
â€ĸ Does not affect sexual
pleasure
â€ĸ Vasectomy does not
affect the male’s ability
to have an erection,
achieve orgasm,
ejaculate
â€ĸ Tubal ligation does not
affect a female’s
hormone production
īą Disadvantages
â€ĸ Complications after
procedure
â€ĸ Time needed for surgery
and recovery
â€ĸ Has risks associated with
surgery
â€ĸ Will not protect from
STIs
â€ĸ Most are non-reversible
10
4
3/22/2021
Family planning
References
105
ī‚— Williams Gynecology- 3rd ed
ī‚— Current Diagnosis & Treatment Obstetrics
& Gynecology, 11TH Edition
ī‚— National Family planning guideline
Ethiopia 2016.
ī‚— Goodman & Gilman’s the pharmacological
bases of therapeutics 12th edition
ī‚— UpTo Date 2018
3/22/2021
Family planning
Family planning
106
3/22/2021

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Family planning

  • 1. Presenters: Solomon N Liyew A Modulated by: Dr. Tizazu(MD, Obstetrician and Gynecologist)
  • 2. OUT LINES īƒ˜Introduction īƒ˜Definition īƒ˜Objectives of FP īƒ˜Classifications of FP methods īƒ˜NFP methods īƒ˜Barrier methods īƒ˜IUCD īƒ˜Hormonal methods īƒ˜Permanent methods 2 3/22/2021 Family planning
  • 5. CONT. â€Ļ ī‚— Rapid population growth (96% in developing countries) is a critical issue worldwide. ī‚— Family planning matters save women’s lives preventing unintended pregnancies. ī‚— Slower population growth, conserves resources, improves health and living standards. 5 3/22/2021 Family planning
  • 6. DEFINITION ī‚— Having the number of children you want when you want them. It is not to control births, but to plan pregnancies but birth control includes abortion to prevent a birthâ€Ļwhere as FP as defined by UN & WHO encompasses service leading upto conception and does not promote abortion as a FP method. 6 3/22/2021 Family planning
  • 7. CONT. â€Ļ ī‚— Contraception and fertility control are not synonymous. ī‚— Fertility control includes both fertility inhibition (contraception) and fertility stimulation ī‚— While the fertility stimulation is related to the problem of the infertile couples, ī‚— The term contraception includes all measures, temporary or permanent, designed to prevent Px due to the coital act. 7 3/22/2021 Family planning
  • 8. Family planning is: 1. Having the number of children based on the couple’s belief, health and economic situation. 2. Spacing births properly. 3. Making sure pregnancies occur only during the right time in a mother’s life. 4. Helping childless couples have children 8 3/22/2021 Family planning
  • 9. Objectives of FP īļ To avoid unwanted pregnancies. īļ To bring about wanted births. īļ To regulate the intervals between pregnancies. īļ To control the time at which births occur in relation to the ages of the parent ; and īļ To determine the number of children in the family. 9 3/22/2021 Family planning
  • 10. ī‚— Ideal contraceptive methods should be: īƒ˜widely acceptable, īƒ˜inexpensive, īƒ˜simple to use, īƒ˜safe, īƒ˜highly effective and īƒ˜requiring minimal motivation, maintenance and supervision. ī‚— So far there is no universally acceptable ideal method. 10 3/22/2021 Family planning
  • 11. Contraceptive efficiency: īƒ˜It is the measurement of unplanned pregnancies even after the use of contraceptive measures in the presence of factors affecting. īƒ˜can be measured by the pearl index. īƒ˜ Pearl Index: no. Of failures/100 woman-years of exposure īƒ˜Failure rate = Total accidental pregnancies × 1200 Total months of exposure 1200=12 months per 100 women 11 3/22/2021 Family planning
  • 13. Health Rationale ī‚— Saves women’s lives and improves their health ī‚— Spaces pregnancies, which saves children’s lives and improves their health ī‚— Benefits couple, family and community ī‚— Helps adolescents make responsible choices ī‚— Allows men to share responsibility for reproductive health and child rearing 13 3/22/2021 Family planning
  • 14. Benefits of family planning 1. For the Mothers īƒ˜Protection from early and unwanted pregnancy īƒ˜Prevention of unsafe abortions īƒ˜Protection from STDs īƒ˜Increased education opportunities īƒ˜Increased job possibilities 14 3/22/2021 Family planning
  • 15. Cont. â€Ļ 2. For the Children īƒ˜Better health īƒ˜More food and resources available īƒ˜Greater opportunity for emotional support from parents īƒ˜Better opportunity for education 3. For the Fathers: īƒ˜Protection from STDs īƒ˜Less emotional and economic strain īƒ˜Improved quality of life 15 3/22/2021 Family planning
  • 16. Cont. â€Ļ 4. For the community īƒ˜ Reduced strain on environmental resources (land, food, water) īƒ˜ Reduced strain on community resources (healthcare, educational and social services) īƒ˜ Greater participation by individuals in community affairs 16 3/22/2021 Family planning
  • 17. Choosing a method Choosing a method depends on: Efficacy Convenience Duration of action Reversibility and time to return of fertility Effect on uterine bleeding Frequency of side effects and adverse events Affordability Protection against sexually transmitted diseases 17 3/22/2021 Family planning
  • 18. Medical Eligibility Criteria for Contraceptive Use, WHO 18 No restriction of method use Method advantages outweigh risks Method poses an unacceptably high Health risk 3/22/2021 Family planning
  • 19. TYPES OF CONTRACEPTION Hormonal Combined hormonal contraception Progestogen-only contraception Emergency hormonal contraception Non hormonal Traditional methods Barrier methods Intra-uterine devices Sterilization: male and female 19 3/22/2021 Family planning
  • 21. 21 CONTRACEPTIVE METHODS NATURAL ARTIFICIAL PERMANENT TEMPORARY BTL VASECTOMY BARRIER IUCD (copper T) HORMONAL ABSTINENCE WITHDRAWAL SDM 3/22/2021 Family planning
  • 22. Classification Natural FP Methods ī‚§ Calendar Rhythm ī‚§ Cervical mucus (billings) ī‚§ Basal Body Temperature ī‚§ Sympto-thermal ī‚§ Lactation Amenorrhea ī‚§ Coitus interruptus (withdrawal) ī‚§ Abstinence Hormonal methods – OCP (COC, POCP) – Hormone bearing IUDs – Injectables – Implants – Contraceptive Skin patches – Vaginal rings Intrauterine devices – Inert forms – Copper bearing – Hormone bearing Barrier methods Condom(Male, Female) Spermicides Cervical caps Diaphragm Permanent methods – Vasectomy – BTL Emergency Contraception 22 3/22/2021 Family planning
  • 23. A . Abstinence īƒ˜Delay sexual activity until financially, emotionally, and physically ready for the responsibilities of childbearing. īƒ˜The only method that is 100% effective. Advantages īƒ˜It protects you from STDs and pregnancy. Disadvantages īƒ˜Coping with peer pressure īƒ˜Motivation is essential 23 NATURAL FAMILY PLANNING 3/22/2021 Family planning
  • 24. B. Post-coital Douching ī‚— Involves washing the vagina by spraying a cleaning solution into the vagina after intercourse ī‚— Ineffective and unreliable method ī‚— Disadvantages Pushes sperm deeper into the vagina increasing the risk of pregnancy Increases the risk of PID Increases the risk of ectopic pregnancy Increases the risk of vaginal yeast infections 24 3/22/2021 Family planning
  • 25. C. Lactational Amenorrhea Method (LAM) īƒ˜Based on scientific evidence that a woman is not fertile and unlikely to become pregnant during full lactation or exclusive breastfeeding (Ovulation is suppressed during lactation). īƒ˜Breastfeeding with no supplemental feeding of any type is given (not even water) and the infant is feeding both(6 hrs) day and night(4hrs) with little separation from the mother. 25 3/22/2021 Family planning
  • 26. Irregular secretion of GnRH interferes with release of follicle stimulating hormone (FSH) and leutinizing hormone (LH) Frequent intense suckling disrupts secretion of Gonadotrophin releasing hormone (GnRH) Decreased FSH and LH disrupts follicular development in the ovary to suppress ovulation LAM: Mechanisms of Action β -Endorphins induced by suckling also induce a decline in the secretion of dopamine, which normally suppresses the release of prolactin. This results in a condition of amenorrhea and anovulation 3/22/2021 Family planning 26
  • 27. Cont. â€Ļ It provides maximum protection as long as: ī‚— The woman is less than six months postpartum ī‚— She is breastfeeding exclusively ī‚— She is amenorrheic NB. If these conditions are not met, the risk of unintended pregnancy while breastfeeding is high. 27 3/22/2021 Family planning
  • 28. Cont. â€Ļ īą Use of COCs generally is not advised during lactation because they reduce the amount and quality of breast milk. īąCan be used after 6 weeks, once milk production is established. īąProgestin-only OCs, implants, and injectable contraception do not affect milk quality or quantity Adv. Free and easily available, decrease breast ca Disadv. Px occur 3/22/2021 Family planning 28
  • 29. D. Coitus interrupts (withdrawal) method ī‚— Involves removing the penis before ejaculation ī‚— Objective is to keep the sperm from entering the vagina Adv. Free Dis adv. Pregnancy could occurme contains sperm cells Depends on male control 29 3/22/2021 Family planning
  • 30. E. Rhythm method īƒ˜ Also called Periodic abstinence or natural contraception. īƒ˜ Relies on abstinence from sexual intercourse during the most fertile phase of a woman’s menstrual cycle. īƒ˜ It needs identification of the fertile (unsafe) and infertile(safe) phases of the menstrual cycle īƒ˜ Fertilization takes place within the tube, and the ovum remains in the tube for approximately 1–3 days after ovulation; īƒ˜ from the time of ovulation to 2–3 days thereafter; 3/22/2021 Family planning 30
  • 31. Cont. â€Ļ Various methods are used; īąCalendar method īąBasal Body Temperature īąCervical Mucus(billings) method īąSympto-Thermal Methods īą The combined temp and calendar method 31 3/22/2021 Family planning
  • 32. 1. Calendar method īƒ˜Requires recording the length of 12 consecutive menstrual cycles. Calculation: 1st day of fertile period = shortest cycle-18 days Last day of fertile period = longest cycle-11 days īƒ˜Sexual intercourse is abstained b/n these days īƒ˜User effectiveness is 20-30/100 women-years Adv. No side effects or health issues Completely natural and free Drawbacks: Only for educated and responsible couples High Failure rate 3/22/2021 Family planning 32
  • 33. 2. Basal Body Temperature īƒ˜more reliable evidence of ovulation īƒ˜Is based on Temp. changes īƒ˜A rise of 0.4 - 0.8 °C above the mean Temp. of the pre-ovulatory phase for 3 days indicates ovulation has occurred. īƒ˜Abstinence is required from the time of menses until 3 days after the rise in temperature. īƒ˜ True basal temperatures are recorded, i.e, fever due to other causes?? 3/22/2021 Family planning 33
  • 34. 3. Cervical Mucus(billings) method ī‚— Also called the ovulation method ī‚— Women takes sample of her mucus everyday for a month ī‚— Under estrogen influence, the mucus increases in quantity and more slippery and elastic until a peak day is reached. ī‚— Scanty and dry under the influence of progesterone ī‚— Women should avoid unprotected sex from the days secretions start until four days after the peak day. 3/22/2021 Family planning 34
  • 35. 35 Cervical Mucus Cycle Beginning Peak End 3/22/2021 Family planning
  • 36. Cont. â€Ļ ī‚— Adv. Free Can be stopped at any time Helps women to be aware of their cycle ī‚— Dis adv. Failure rate is 20% per year Requires effort and work Because sperm may survive 5 to 7 days in the female genital tract īƒ˜User effectiveness is 15-20/100 women years 36 3/22/2021 Family planning
  • 37. 4. Sympto-Thermal Methods â€ĸ If used properly, probably is the most effective of all the periodic abstinence approaches. â€ĸ It combines the cervical mucus and the temp methods. â€ĸ In addition, symptoms that may occur just prior to ovulation,- bloating , slight cramping and breast tenderness, are used as adjuncts 5. The combined temp and calendar method; ī‚— Failure rates of only 5 px/ 100 women year 3/22/2021 Family planning 37
  • 39. Physicalmethods 1. condoms : A. Male condom ī‚— Made up of fine latex sheath ī‚— Most widely used barrier in males ī‚— Highly effective if used correctly Failure rate: 2-3 %â€Ļ mainly due to improper and inconsistent use Advantage: ī‚— Simple spacing method ī‚— No side effects ī‚— Easily available, safe & inexpensive ī‚— Protects against STD ī‚— Also protection from cervical Neoplasia Disadvantage: ī‚— Chances of slip off and tear off ī‚— Some men are allergic to latex ī‚— Those with spermicide may cause irritation 3/22/2021 Family planning 39
  • 40. B. Female condom īƒ˜Strong, soft, transparent vaginal pouch made of polyurethane sheath īƒ˜ Inserted before sexual intercourse īƒ˜Has two flexible rings īļ The outer ringâ€Ļthe larger, open ring stays outside the vagina, īļ The inner ring â€Ļat the closed end of the condom eases insertion into the vagina, covering the cervix and holding the condom in place 3/22/2021 Family planning 40
  • 41. Cont. â€Ļ ī‚§ Breakage, less and slippage more, than male condom ī‚§ Inserted for up to 8 hours 41 Adv Stronger Offers greater protection No side effects of hormone Prevention stds Dis adv. Allergy Tear or damage unnoticed Difficulties in insertion and removal More expensive 3/22/2021 Family planning
  • 42. 2. diaphragm ī‚— A mechanical barrier between the vagina and the cervical canal.. īļProper fitting is key īļA contraceptive jelly or cream should be placed on the cervical side before insertion. ī‚— 6 hrs prior to intercourse & left in place for 6–8 hrs after. 42 3/22/2021 Family planning
  • 43. Cont. â€Ļ ī‚— Pearl index 10–20 īą If intercourse is repeated, additional spermicidal inserted into the vagina without removing the diaphragm. īą It is then removed, washed with soap, dry, and store away from heat. īą not be dusted with talc powder Adv- Some protection against STD and reused – 1 yrs. Dis adv; ī‚— Vaginal wall irritation ī‚— Risk of UTI ī‚— Requiring fitting by a physician or a trained 3/22/2021 Family planning 43
  • 44. 3. Cervical cap ī‚— Is a rubber cup with metallic rim designed to fit the cervix ī‚— smaller as compared to diaphragm ī‚— Used with a spermicide ī‚— Applied over cervix before intercourse ī‚— left in place for 8–48 hours after intercourse ī‚§ Pearl Index 11 – 19 % Dis adv. difficulty in placing displacement high Cervicitis and local irritation a foul discharge if >1 day of use 44 3/22/2021 Family planning
  • 45. Chemical barriers ī‚— Spermicidal agents which can destroy sperms when applied in female genital tract 10-15 min before each sexual act ī‚— used alone or in conjunction with a diaphragm , cervical cup or condom. ī‚— Various preparations as 1) Foams 2) Creams. Jellies, Paste 3) Suppositories 4) Soluble films Adv: Inexpensive Well tolerated Good protection 45 3/22/2021 Family planning
  • 46. Intrauterine contraceptive device (IUD) Two types of IUD : 1. Copper T 380A (Paragard) 2. Levonorgestrel releasing IUD- Mirena, Skyla and Liletta 46 Proper placement of cu T 380A 3/22/2021 Family planning
  • 47. Description of IUD’s i. Cu T 380A: carries 380 mm2 area of copper wire wound around the vertical & horizontal arms. It is removed every 10 years ii. Multiload Cu375: it has 375 mm2 of copper wire. It is removed every 5 years iii. Multiload Cu250: No introducer & plunger and removed every 3 years. 47 3/22/2021 Family planning
  • 48. Mechanism of Action Family planning ī‚— Intense local endometrial inflammatory response is induced, by copper-containing devices. ī‚— Lead to decreased sperm and egg viability. ī‚— The progestin renders the endometrium atrophic ī‚— Impaired sperm ascent ī‚— Prevent implantation ī‚— Thick cervical mucus, 3/22/2021 48
  • 49. Levonorgestrel Intrauterine system:>99% ī‚§ There are Three different levonorgestrel-releasing intrauterine systems-IUD- Mirena, Skyla and Liletta ī‚§ Their T-shaped radiopaque frames have a stem wrapped with a cylinder reservoir that contains the levonorgestrel. ī‚§ The cylinder has a permeable membrane that regulates continuous daily hormone release 49 Cont. â€Ļ 3/22/2021 Family planning
  • 50. a. Mirena īƒ˜ For 5-7 years īƒ˜ Initial levonorgestrel release rate is 20 mcg/day; rate reduced by 50% after 5 years īƒ˜ Follow up 4-12 weeks after insertion b. Skyla and liletta īƒ˜ For 3 years īƒ˜ Levonorgestrel release rate is 14 mcg/day and 5 mcg/day after 3 years īƒ˜ Follow up 4-6 weeks after insertion 50 Cont. â€Ļ 3/22/2021 Family planning
  • 51. Initiation: within 7 days after menstrual period begins /Immediately to 2 wks following abortion/ Side effects: īƒŧ Mal positioning of the device īƒŧPain or bleeding īƒŧIrregular spotting for up to 6 mths after insertion and there after to expect monthly menses to be lighter or even absent /progressive amenorrhea/. īƒŧCycles may be even heaver than the normal/ Menorrhagia, Anemia/ 51 Cont. â€Ļ 3/22/2021 Family planning
  • 52. Fertility issues: īƒ˜ endometrium recovers quickly, normal ovulations are established and the fertility seems to be unaffected after use of an LNG- IUD. 52 Cont. â€Ļ 3/22/2021 Family planning
  • 53. Complications Immediate: Cramp like pain Partial or complete perforation Remote: Pain AUB Pelvic infection Spontaneous expulsion Perforation of the uterus Pregnancy Missing thread 53 3/22/2021 Family planning
  • 54. Indications for removal of IUDs 1. Persistent menstrual problems 2. Tube -ovarian abscess 3. Perforation of the uterus 4. Partial expulsion 5. Pregnancy with IUD 6. Desiring fertility/ planning pregnancy 7. Missing thread 8. One year after menopause 9. Effective life span is over 54 3/22/2021 Family planning
  • 56. HORMONAL CONTRACEPTION īļIt is classified in to two īļHCPs are one of the most widely used world wide; CHCs POPs īļ They are available in the form of pill, injectable, implant 56 3/22/2021 Family planning
  • 57. Composition Route Duration -CHC (E + P) -Oral(COC, POP, Emergency -Long acting (L, E+L) ) (LNIURS, implants) -short acting -Progesterone only -injectable (MPA) (others) -implant (levonor) -IUD (LNIURS) Family planning 3/22/2021 57 Classifications of Hormonal Contraceptives
  • 59. Cont. â€Ļ It is a combination of two steroids hormones īļThese are:- īƒŧEstrogen īƒŧProgesterone īļ It is given for 21 days and 7 free day period. 59 3/22/2021 Family planning
  • 60. Estrogen Progestin Monophasic EE 35 mcg Norethindrone 0.5mg Biphasic EE 35 mcg Norethindrone 0.5mg EE 35 mcg Norethindrone 1 mg Triphasic EE 30 mcg Levonorgestrel 0.05 mg EE 40 mcg Levonorgestrel 0.075 mg EE 30 mcg Levonorgestrel 0.125 mg Types of preparation 60 3/22/2021 Family planning
  • 61. BIPHASICS AND TRIPHASICS īļMultiphasic pills were developed to reduce the amount o total progestin per cycle without sacrifcing contraceptive effcacy or cycle control. īļUseful when there is breakthrough bleeding. īąAdv īļ Tend to give a more natural bleeding pattern īļ Iimitate the normal menstrual cycle & hormonal fluctuations more closely than monophasics 61 3/22/2021 Family planning
  • 62. Mechanisms of Action Suppress ovulation Change endometrium making implantation less likely Thicken cervical mucus (preventing sperm penetration) Reduce sperm transport in upper genital tract (fallopian tubes) 62 3/22/2021 Family planning
  • 64. Disadvantage and Side effects īƒ˜ User dependent( require continued motivation and daily use) īƒ˜ Effectiveness may be lowered by certain drugs īƒ˜ Forgetfulness increase the failure īƒ˜Does not protect against STIs 64 3/22/2021 Family planning
  • 65. Cont. â€Ļ CARDIO VASCULAR SYSTEM Thrombo embolic disease Ischemic heart disease especially in predisposed CENTRAL NERVOUS SYSTEM STROKE Liver slight transient impairment of liver function cholestasis increased incidence of gallstone( associated with high biliary cholesterol secretion). 65 3/22/2021 Family planning
  • 66. Cont. â€Ļ Carbohydrate metabolism â€ĸ Impairment in glucose metabolism, especialy in predisposed. â€ĸ Diabetes if present become more difficult to control( b/c of effect in liver metabolism and progesterone insulin antagonism effect. Lactation-decrease milk production . 66 3/22/2021 Family planning
  • 67. Contiâ€Ļ ī‚§ Nausea and vomiting ī‚§ headache ,irritability and depression ī‚§ Breast engorgement, tenderness& enlargement ī‚§ Skin pigmentation Menstrual disturbance ī‚§ Spotting ī‚§ Break though bleeding ī‚§ Amenorrhea 67 3/22/2021 Family planning
  • 68. Contraindication ī‚— Hypertension ī‚— Some known hyperlipedimia ī‚— Smoking ,<15cigrret/day ī‚— age â‰Ĩ35 ī‚— Obesity and migraine ī‚— Current or treated gall bladder disease ī‚— History of choliostasis ī‚— Mild cirrhosis ī‚— Rifampicin and anti convelsant drugs 68 3/22/2021 Family planning
  • 69. Cont. â€Ļ īļ Absolute â€ĸ Breast feeding <6 month of post partum â€ĸ Multiple cardiovascular risk factor â€ĸ HTN >160/110 mmhg â€ĸ Current problem of venous thrombo embolism â€ĸ Major surgery with prolonged immobilization â€ĸ Current ischemic heart disease and stroke â€ĸ DM with vascular complication â€ĸ Sever cirrhosis â€ĸ Women over age 35 years who smoke Family planning 69 3/22/2021
  • 70. Indications for withdrawal in COC īƒŧ With Sx/Sn that indicate major side effect. īƒŧ Elective surgery:- 4weeks before, but if emergency use heparin. īƒŧ Visual disturbances īƒŧ Sudden chest pain with DVT īƒŧ Severe cramp & pains in leg īƒŧ Severe depression īƒŧ when pregnancy is needed 70 3/22/2021 Family planning
  • 71. PROGESTRON ONLY PILLS īļ Contain only progestin derivatives īļ It avoid side effect of estrogen īļ It is prepared in the form oral, injectable and implant. . 71 3/22/2021 Family planning
  • 72. Cont. â€Ļ īļThe commonly used progestin are: īƒ˜levonogestrel 75 g īƒ˜norethisteron 350 g īƒ˜ethinodiol di acetate 500 g īƒ˜desogestrel 75 g īƒ˜lynestrol 500 g īƒ˜norgestrel 30 g. īļThey have to be taken with no hormone free interval 72 3/22/2021 Family planning
  • 73. Mechanism of action 73 1. Thicken cervical mucus ,preventing sperm penetration 2. Suppress ovulation 3. Makes the endometrial less favorable for penetration. 4. Reduce sperm transport in upper genital tract(fallopian tube) 3/22/2021 Family planning
  • 74. Cont. â€Ļ 74 īļ If a woman using a POP misses her dose by more than three hours it is quite likely that she is not protected. Advantages: ī‚— Side effects of estrogen will be eliminated ī‚— No adverse effect on lactation ī‚— No “on & off” regimen during taking ī‚— Can be used in Hypertensive pts. 3/22/2021 Family planning
  • 75. Cont. â€Ļ Adv. ī‚§ Precise timing, failurity ī‚§ Acne ī‚§ Changes in menstrual pattern(irregular bleeding/spotting initially ) Contra â€ĸ Pregnancy â€ĸ Known or suspected cancer reproductive tract and breast â€ĸ Undiagnosed genital tract bleeding â€ĸ Taking drug like rifampicin, phentoyin,and barbiturates ??? Family planning 75 3/22/2021
  • 76. Injectable steroids 1. DMPA (Depo-Proveraīƒ’. medroxyprogesterone acetate ) ī‚— 150 mg IM every 3 months. ī‚— It is most effective contraceptive method with failure rate of 0.3% s/e- – Slow return to fertility – Irregular bleeding – WT gain – Amenoria – Short-term loss of bone mineral density/ Osteoclasts/ 76 3/22/2021 Family planning
  • 77. ī‚— Implant system(1, 2, 6 rods) ī‚— >99%: thin, pliable progestin-containing cylinders that are implanted subdermally and release hormone over many years. . 77 Contraceptive implant 3/22/2021 Family planning
  • 78. Implant systems: after removal fertility comes immediately. 78 Cont. â€Ļ 3/22/2021 Family planning
  • 79. 79 Cont. â€Ļ Implanon īļ Single rod containing Etonogestrel - Subdermally (medial surface of the upper arm 8 to 10 cm from the elbow) - every 3 yrs - 68 mg - Efficacy is extremely high 3/22/2021 Family planning
  • 80. Cont. â€Ļ 2) Norplant: ī‚— six rod for five years with each rod containing 38 mg of levonorgestrel releasing initially 85ug/day and later 30ug/day over five years. 80 3/22/2021 Family planning
  • 81. Implant 3) Jadelle ÂŽ ī‚— 2 rods ī‚— Effective 5 years ī‚— 1-yr failure: 0.05% (1 in 20,000); 5-yr failure 1.1% 4) Sinoplant – 2 rod used for 4 years 81 3/22/2021 Family planning
  • 82. Mechanism of Action ī‚— Suppresses ovulation ī‚— Increases cervical mucus viscosity ī‚— Alters endometrium 82 3/22/2021 Family planning
  • 83. Features of Implants â€ĸ Highly effective â€ĸ Can be used during lactation â€ĸ Rapidly reversible â€ĸ Contain no estrogen â€ĸ Safe 3/22/2021 Family planning 83
  • 84. Side effects: īļmalpositioning of rods during placement. ī‚— Can cause irregular bleeding ī‚— Requires clinician visits for insertion and removal ī‚— Does not protect from STDs 84 Cont. â€Ļ 3/22/2021 Family planning
  • 85. Cont. â€Ļ 85 Adv; â€ĸ Long term use â€ĸ Immediate return of fertility on removal Dis adv; â€ĸ Requires trained provider for insertion and Removal â€ĸ Women cannot stop whenever they want. â€ĸ Infection at insertion site. 3/22/2021 Family planning
  • 86. EMERGENCY HORMONAL CONTRACEPTION Any woman of reproductive age may need at some point to avoid unwanted pregnancy, following situations such as: īļ After unprotected sexual intercourse īļAfter incorrect use of regular contraceptive methods īļ Sexual assault 86 3/22/2021 Family planning
  • 87. Cont. â€Ļ ī‚— Condom breakage or slippage. ī‚— Miscalculation of the infertile period when using periodic abstinence ī‚— failure to abstain from sexual intercourse during the fertile days. ī‚— Expulsion of an IUD. 87 3/22/2021 Family planning
  • 89. Cont. â€Ļ The standard regimen consists of the “combined” oral pills. This regimen is known as the “Yuzpe method” īąHigh-dose pills containing 50 ug of ethinylestradiol and 250 ug levonorgestrel (or 500 ug dl-norgestrel) īļ Two pills should be taken as the first dose as soon as convenient but no later than 72 hours after unprotected intercourse. These should be followed by two other pills 12 hours later. 89 3/22/2021 Family planning
  • 90. Cont. â€Ļ īąlow-dose pills containing 30ug ethinylestradiol and 150uglevonorgestrel (or 300 ug dl-norgestrel) īļ Four pills should be taken as the first dose as soon as convenient but no later than 72 hours after unprotected intercourse. These should be followed by another four pills 12 hours later. 90 3/22/2021 Family planning
  • 91. Cont. â€Ļ īąlevonorgestrel-only pills (post pill) containing 750ug(0.75mg) levonorgestrel īļ One pill should be taken as the first dose as soon as convenient but no later than 72 hours after unprotected intercourse. This should be followed by another pill 12 hours later. 91 3/22/2021 Family planning
  • 92. 3. Copper-containing IUDs (CU T 380 A)- >99% This can be used up to five days after unprotected intercourse. MOA- īƒŧ interference with fertilization īƒŧ prevent implantation of a fertilized egg S/e- Nausea, Vomiting, Breast tenderness, Headache, menstrual disturbance & Ectopic pregnacy 92 Cont. â€Ļ 3/22/2021 Family planning
  • 93. Trials â€Ļ ī‚§ Hormonal male contraception clinical trials began in the 1970s. ī‚§ The method is based on the use of exogenous testosterone alone or in combination with a progestin to suppress the endogenous production of testosterone and spermatogenesis. ī‚§ Studies using testosterone alone showed that the method was very effective with few adverse effects. 3/22/2021 Family planning 93 Male Hormonal Contraceptive â€Ļ the new era
  • 94. ī‚§ Addition of a progestin increases the rate and extent of suppression of spermatogenesis (decrease sperm count). ī‚§ Common adverse effects include acne, injection site pain, mood change including depression, and changes in libido. ī‚§ Current development includes long-acting injectables and transdermal gels and novel androgens that may have both androgenic and progestational activities. 3/22/2021 Family planning 94 Male Hormonal Contraceptive â€Ļ the new era
  • 95. 3/22/2021 Family planning 95 Male Hormonal Contraceptive â€Ļ the new eraâ€Ļ MOA
  • 96. īļ Men were given progestogen (NET-EN, 200mg) and testosterone injections (TU,1000mg) into the buttock muscles at the beginning of the study and then at 8, 16 and 24 weeks. (peer reviewed Journal of Endocrinology and metabolism)- involving 320 men īƒŧ Effectiveness- 98.4% īƒŧ Acne- 49.9% īƒŧ Mood disorder- 0.016% īƒŧ did not recover their sperm count one year after stopping the injections- 5% ?????? 96 Male Hormonal Contraceptive â€Ļ the new era 3/22/2021 Family planning
  • 97. Terminal methods ī‚¨ A surgical method where by the reproductive function of an individual male or female is purposefully & permanently destroyed ī‚¨ Vasectomy in male and tubal occlusion in female ī‚¨ Couple need to be adequately informed before any permanent procedure 97 3/22/2021 Family planning
  • 98. Vasectomy ī‚¨ Segment of vas deferens of both sides are resected and cut ends are ligated ī‚¨ Advantages: 1. Simple 2. Failure rate is low (0.15%) 3. Minimal expenditures 98 3/22/2021 Family planning
  • 99. Vasectomyâ€Ļ ī‚¨ Drawbacks: 1. Additional contraceptive needed for the first 2- 3 months 2. Psychological Fair of impotence ī‚¨ Candidates: 1. Sexually active, psychological prepared & completed fertility 2. No eczema or scabies around scrotal region 3. Correct hernia &/or hydrocele before vasectomy 99 3/22/2021 Family planning
  • 100. complications ī‚¨ Immediate: 1. Wound infection and sepsis 2. Scrotal hematoma ī‚¨ Remote: 1. Spontaneous recanalization 100 3/22/2021 Family planning
  • 101. Female sterilisation ī‚¨ Most popular method of terminal contraception world wide ī‚¨ Occlusion of both fallopian tubes â€ĸ Tubal ligation â€ĸ Bilaterally â€ĸ The most common surgical sterilization procedure for women 101 3/22/2021 Family planning
  • 102. Cont. â€Ļ 102 â€ĸ the fallopian tubes are either cut and separated or they are sealed shut. â€ĸ This prevents the egg and sperm from meeting and thus prevents pregnancy ī‚¨ Indications: 1. Family planning purposes 2. After having the desired number of children 3. Medico-surgical indications (therapeutic) 3/22/2021 Family planning
  • 103. Cont. â€Ļ â€ĸ The procedure can be performed īŽ postpartum (within 48 hours post-vaginal delivery), īŽ at the time of cesarean delivery, īŽ interval or concurrent medical termination īŽ as an interval procedure (>6 weeks postpartum) via laparoscopy or mini- laparotomy (rarer). ī‚¨ Ligation could be abdominal,or laparascopic ī‚¨ Different surgical types 103 3/22/2021 Family planning
  • 104. Effects of Sterilization īą Benefits ī‚§ Effects are immediate â€ĸ Does not affect sexual pleasure â€ĸ Vasectomy does not affect the male’s ability to have an erection, achieve orgasm, ejaculate â€ĸ Tubal ligation does not affect a female’s hormone production īą Disadvantages â€ĸ Complications after procedure â€ĸ Time needed for surgery and recovery â€ĸ Has risks associated with surgery â€ĸ Will not protect from STIs â€ĸ Most are non-reversible 10 4 3/22/2021 Family planning
  • 105. References 105 ī‚— Williams Gynecology- 3rd ed ī‚— Current Diagnosis & Treatment Obstetrics & Gynecology, 11TH Edition ī‚— National Family planning guideline Ethiopia 2016. ī‚— Goodman & Gilman’s the pharmacological bases of therapeutics 12th edition ī‚— UpTo Date 2018 3/22/2021 Family planning