Genital warts are caused by Human papillomavirus (HPV). Basically it is a symptom of HPV appear in the skin of the genital area. Imiquimod is an approved drug by USFDA to treat Genital warts.

1. Genital Warts &
Role of IMIQUIMOD Cream
Shuman Chandra Das
A-Grade Pharmacist
Dhaka, Bangladesh

2. Ref.: An armamentarium of wart treatments, Clinical Medicine & Research,
Vol.4, Number:4:273-293
70%
Sexually active women become infected with
HPV during their lifetime.

3. HPV infection in men is most commonly
presented as genital warts or condylomata
(benign epithelial tumors)
Ref.: Suzanne Albrecht, HPV in men: treatment and prevention strategies;
US pharmacist, august 19, 2008.

4. Genital warts causes…

5. Most Common Location of External Genital Warts
Women
Vulva,
Perianal
area
Men
Penile
shaft,
Perianal
area
Ref: Journal of Women’s Health 2004. 13:265-271

6. “Different destructive or ablative
treatment modalities have the
disadvantage of high recurrence rates
due to an incomplete elimination of HPV
infected cells around the visible lesions.”
Ref. : Br J Dermatol. 2007 Dec;157 Suppl 2:52-5

7. Imiquimod is an immunomodulating agent that
was approved by the FDA in 1997 for treatment
of external genital and perianal HPV infections for
patients age 12 years and over.
Ref.: Comprehensive Dermatologic Drug Therapy
by Wolverton, 3rd Edition

8. “Imiquimod has an
efficacy similar to
Cryotherapy and
yields a low
recurrence rate.”
“Imiquimod is more
effective than
podophyllotoxin in
treating women with
external genital
warts.”
“Less mild-to-
moderate irritation
than with Imiquimod
compare to
podophyllin or
cryotherapy in men &
women”
Ref.: Andrew’s Diseases of the skin clinical dermatology, 10th Edition
Imiquimod is a recommended drug

9. “Imiquimod, a potent stimulator of the release of several
proinflammatory cytokines that acts at least in part by activation of
Toll-like receptors 7 & 8, is approved for patient-applied therapy
treatment of genital warts.”
Ref.: Fitzpatrick’s Dermatology in General Medicine, 8th Edition
Imiquimod is a recommended drug

10. Imiquimod Clinical Efficacy

11. Imiquimod Clinical Efficacy

12. Imiquimod Ensures less recurrence
50%
33%Cryotherapy
22%Surgical excision
8%
Imiquimod
Laser therapy
Ref.: 1 & 3. Infect Dis Obstet Gynecol 2002;10:79-88, 2 & 4. International
Journal of STD & AIDS 2008;19:441-444, 4.
Imiquimod Clinical Efficacy

13. Imiquimod Clinical Efficacy

14. Imiquimod Clinical Efficacy

15. According to
Europeanand CDCtreatment guidelines
Imiquimod is Recommended for
Genital Warts
Ref: Journal of Women’s Health 2004. 13:265-271

16. Imiclara (Imiquimod)
Fights viral infection
Releases cytokines: Interferon, TNF, IL
Prevents virus multiply
Stimulates immune cell
Heals genital warts
Acts as toll-like receptor-7 agonist
Imiquimod Mechanism of Action
Against Genital warts

17. Imiquimod Cream

18. Imiquimod Cream

19. Please visit
www.antiagingyoung.com

20. Thank You
Shuman Chandra Das
A-Grade Pharmacist
Dhaka, Bangladesh