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1. COMPLEMENT TEST SERVICES
Specialized complement test services to promote your research and drug development.
www.creative-biolabs.com/complement-therapeutics

2. About Us
Creative Biolabs is a leading diagnostic service company with a robust and
standardized complement assay platform, supporting basic and preclinical research
in complement.
We offer a full range of complement function or activity test services and use high-
quality standards in all operations, testing procedures and reports. Our specialized
and dedicated team of scientists are available to support our clients with R&D, pre-
clinical and clinical trial programs.
Complement Test

3. Content
Introduction
Services
Advantages
Contact Us

4. Complement test is a blood test that measures the activity of a group
of proteins in the bloodstream. These proteins make up the
complement system, which is one part of the immune system. The
complement system helps antibodies fight off infections and destroy
substances that are foreign to the body. However, when the following
conditions occur in the complement system: (1) abnormal function of
complement components and activation products, (2) production of
autoantibody to complement protein, (3) mutations in the complement
gene, it may lead to autoimmune diseases and other inflammatory
reactions. Complement tests contribute to determining whether
deficiencies or abnormalities in the complement system are causing or
contributing to the patient’s disease or condition.
Complement Test Introduction
What is a complement test ?

5. Complement Test Can be Used to:
Diagnose infectious
diseases
Help diagnose the cause of recurrent
microbial infections (such as Streptococcus
pneumoniae, Neisseria meningitides,
Neisseria gonorrhea), angioedema, or
inflammation.
Diagnose other
diseases
Help diagnose, monitor and treat
autoimmune diseases and immune
complex-related conditions.
Develop new
therapies
Help develop new complement-targeted
therapies to inhibit or enhance
complement function in research
settings, determining efficacy and
potency of complement-targeted drugs.

6. Complement function or activity test allows
for the determination of whether the protein
is present and whether it has normal
functional activity.
In addition to the serological test,
genetic test is also important for
determining the risk of disease.
Since complement autoantibodies are
closely related to many diseases,
complement autoantibody tests are very
useful tools for diagnosing, assessing,
and monitoring disease activity, as well
as developing new therapies.
Complement
function/activity test
Complement
autoantibody test
Complement genetic
test
Complement Test Services

7. Complement Function/Activity Test
Individual complement
components can be quantitatively
tested by immunoprecipitation
assays. If the quantitative test does
not reveal any defects, a
functional test is required to verify
the diagnosis.
The complement activation products are
only produced when complement is
activated, so the complement activation
products test can reflect the actual
activation state of the complement system
under pathological conditions.
The total complement activity contributes to a
comprehensive understanding of the activation status of
the complement system to better define disease
occurrence, severity, and response to treatment. Therefore,
the total complement activity test has very important
clinical value in the diagnosis and subsequent treatment
of complement-related diseases.
Total Complement
Activity Test
Complement Activation
Products Test
Individual
Components
Activity Test

8. Total complement activity testing provides a comprehensive insight
into the activation state of the complement system to better define
disease occurrence, severity, and response to treatment. Therefore,
the complement activity test has very important clinical
significance in the diagnosis and subsequent treatment of diseases.
Classical pathway
(CH50 and its
equivalents)
Alternative
pathway (AH50 or
APH50)
Mannan-binding
lectin pathway
(ELISA)
C5b-9 molecule
(ELISA)
The most common methods for testing the total activity of the
complement system include hemolysis assays (CH50 or AH50) or
automated methods such as liposomal lysis and ELISAs. We offer a
sophisticated menu of complement activity tests that enables
determination of specific activity of all three pathways separately
without interference from the others.
Total Complement Activity Test

9. In general, C3, C4 and B factors are the most commonly tested
components, followed by C1 inhibitors and other components.
We provide our customers with routine quantitative tests and
functional activity test for individual components as well as a
full range of complement components testing services,
including but not limited to:
If CH50 and AH50 indicates complement deficiency?
Yes No
Quantitative Tests Functional Activity Test
Nephelometry
Turbidimetry
RID
Testing for the sample's
capability to reconstitute the
total complement activity of a
serum deficient.
 C1q
 C1 inhibitor
 C2
 C3
 C4
 Factor B
 Factor D
 Factor H
 MASP-1/2
Individual Components Activity Test

10. 1
The complement activation products can reflect the actual activation state of the
complement system under pathological conditions because their increase occurs
only when the complement enzymes are formed and complement is activated.
2
Creative Biolabs has developed a variety of specific monoclonal antibodies that
can be used for the testing of complement activation products. Our testing
services for complement activation products, including:
• C3 activation products
• C4 activation products
• Factor B activation products
• C1rs-C1 inhibitor
• C3bBbP
Complement Activation Products Test

11. Since complement autoantibodies are closely associated with many diseases, complement autoantibody tests are very useful tools for the diagnosis,
assessment and monitoring of disease activity, differential diagnosis of clinical manifestations, and development of disease-targeted therapies.
Currently, the most studied complement autoantibodies include C1q, C1-INH, C3, FH/FB autoantibodies and C3Nefs. Most of these complement
autoantibody assays are based on ELISA, while the rest can be detected by other methods, such as immunofixation electrophoresis and hemolytic assays.
Creative Biolabs performs a comprehensive range of autoantibody tests including:
Complement Autoantibody Test
Anti-C1q
Autoantibody
Test
Help diagnose the cause of
recurrent microbial
infections (such as
Streptococcus pneumoniae,
Neisseria meningitides,
Neisseria gonorrhea),
angioedema, or
inflammation.
Anti-C3
Autoantibody
Test
C1-INH
Autoantibody
Test
C3Nefs Test
Anti-FH
Autoantibody
Test
Anti-FB
Autoantibody
Test
Anti-C3 autoantibody is
usually measured by
ELISA with purified C3
immobilized on the
microtiter plate.
The quantity of IgG, IgA
and IgM type antibodies
reacting with the C1-INH
protein can be assessed by
ELISA.
C3Nefs tests are based on
measuring the binding of
NFs to the preformed C3
convertase (binding assays)
or measuring C3 convertase
activity (functional assays).
Autoantibody to FH can be
detected by ELISA with
purified proteins
immobilized on the
microtiter plate.
The anti-FB autoantibody
can be deleted by ELISA,
which contributes to the
diagnosis of related
diseases and the
development of targeted
therapies.

12. Comprehensive testing of genetic variants in the complement
system is available and helpful for many conditions. Creative
Biolabs is a complement test supplier that develops and offers
advanced complement genetic testing. Our powerful sequencing
technologies and precise bioinformatics pipelines ensure superior
genetic testing and report analysis. Our complement genetic test
services can address the significant unmet need for accurate and
timely diagnosis, monitoring and targeted therapy of complement-
related disease. Creative Biolabs performs a comprehensive range
of complement genetic tests (C2, C3, C4, CFI, CFH, MCP, CFB,
CFHR1-5 ) for disease basic and clinical research, including but
not limited to:
• Thrombotic Microangiopathy (TMA)
• Atypical hemolytic uremic syndrome (aHUS)
• Age-related macular degeneration (AMD)
• C3 glomerulopathy (C3G)
• Dense deposit disease (DDD)
• Thrombotic thrombocytopenic purpura (TTP)
• Preeclampsia
Complement Genetic Test

13. Our Advantages
 Have a mature testing system
 Advanced laboratory equipment,
experienced scientists
 Support for clinical as well as
nonclinical studies
 Excellent experimental
environment and perfect
experimental platform to provide
you with the best service
Services features: Why choose us?
 10 years+ of exploration &
development
 Full range of one-stop services for
complement test
 Fully customizable project procedure
 Your best partner in complement test

14. Address
USA HQ Mailing Address:
45-1 Ramsey Road, Shirley, NY
11967, USA
E-mail
info@creative-biolabs.com
Phone/Fax
1-631-466-5530 (Phone)
1-631-207-8356 (Fax)
Contact Us