This document provides information on antibodies for breast cancer research from Creative Biolabs. It discusses the types and prevalence of breast cancer and key markers. It then provides a table listing antibodies for commonly mutated targets in breast cancer research, including targets, clone, applications and species reactivity. The document also discusses popular antibodies for other key markers and signaling factors involved in breast cancer.

1. Antibodies for
Breast Cancer
Research
Antibodies: detection, imaging, diagnostic, etc.
Increase Your Efficiency and Value with
Consistent Performance
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2. Creative Biolabs offers high quality ready-to-use
catalogue antibodies, as well as flexible and
comprehensive customized services for the antibody
production to facilitate the basic discovery of breast
cancer. Empowered by extensive experience and
senior teams, we are committed to offering cutting-
edge antibodies with superior performance for a
wide range of applications to best maximize the
success of your projects at the forefront of
technological innovation.
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High-quality & validated
antibodies for all your needs
01
Antibodies for
Breast Cancer Research

3. Breast Cancer
Breast cancer is the principle cause of cancer-related mortality
among women worldwide. It's highly heterogeneous and can be
classified into 3 types - TNBC, HER2+ and Luminal (non-HER2+).
• ESR1
• HER2/ERBB2
• Ki67
• Progesteron
receptor (PGR)
Key markers
A Quick Glance at Key Targets in Breast Cancer
Kind reminder: If you are interested in any other targets, please visit our website or contact us.
Key signaling factors
Types, frequency and associated mutant genes
• TBL1XR1
• p16Ink4A
/CDKN2A
• MYB
• FOXA1
• GATA3
• CBFB
• RUNX1
• NCOR1
TNBC Triple-negative breast cancers are ER-PR-HER2- and show significant but not complete overlap with the
basal-like subtype of breast cancer (which is defined by differentiation state and gene expression profile).
HER2+ breast cancers
have luminal features and are
characterized by ERBB2 gene
amplification and overexpression,
leading to a dependency on HER2
signaling.
Luminal (non-HER2+)
tumors are typically estrogen receptor
positive, displaying high ERα levels.
These tumors are dependent on
estrogen for growth and, therefore,
respond to endocrine therapy.
TNBC
10%
HER2+
20%
Luminal,
non-HER2+
70%
• ERK2/MAPK1
• MAP2K4
• JNK/MAPK8
• STMN2
• PIK3R1
• PIK3R3
• Cyclin D1/CCND1
• Cyclin D3/CCND3
• CDK4
• PRB1/2
• NCOA3
• MYC
• AKT2
• PTEN
• MDM2
• p53
• TBX3
• GSK3B
• SRC
• RAS
• BRAF
• MEK1
• MEK2
• ERK1/MAPK3
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• TP53
• PIK3CA
• GATA3
• MAP3K1
• MLL3
• CDH1
Commonly mutated targets
• USH2A
• PTEN
• RUNX1
• NCOR1
• RB1
• TBX3
• FOXA1
• CDKN1B
• PIK3R1
• CTCF
• NF1
• SF3B1
• AKT1
• CBFB
Antibodies for
Breast Cancer Research

4. Antibodies for commonly mutated targets
Targets Clone Applications Species reactivity Cat.No.
TP53
1285C WB, IHC, IF, P, FC Human, Mouse CBMAB-1838CQ
CBWJW-083 WB, P, PE Human, Mouse, Rat CBMAB-T0002-WJ
1F7 IP, M, WB Human CBMAB-0266-LY
PIK3CA
CBYC-P379 WB, IP, IC, IF Human CBMAB-P1796-YC
H.843.0 P, IP, WB Cattle, Human,Mouse, Rat CBMAB-P1797-YC
4F3 WB, E, F, IC, IF Human CBMAB-P1795-YC
GATA3
1A12-1D9 IC, IF, P, IP, WB Human, Mouse, Rat CBMAB-G2217-LY
7B5 E, IH, P, WB Human CBMAB-G2223-LY
CBLG1-676 IC/IF, P, IP, WB Human CBMAB-G2244-LY
MAP3K1
CBFYM-0114 F, IF, P, WB Human CBMAB-M0132-FY
9D8 WB Human CBMAB-1022-YC
3A10 E, F, IC, IF, WB Human, Mouse CBMAB-1021-YC
MLL3
CBFYM-1193 WB, E Human CBMAB-M1350-FY
1686CT202.60.69 WB Human CBMAB-K1430-LY
CDH1
CBYY-C0043 IS, WB, IF, IH, IP Human, Dog, Mouse, Rat CBMAB-C0119-YY
3G44 F, IF, IH, IP, WB Human, Mouse CBMAB-C6150-LY
3G42 E, F, IF, IH, IP, WB Human CBMAB-C6148-LY
USH2A CBXU-038 WB Human CBMAB-U0154-CQ
PTEN
10BA33 IF, WB Human CBMAB-1516CQ
D4.3 WB, IP
Human, Mouse, Rat, Hamster,
Monkey, Dog, Chicken
CBMAB-P3310-YC
1B8 E, F, IC, IF, WB Human, Mouse CBMAB-P3306-YC
RUNX1
CBYC-A1038 F Human, Monkey CBMAB-A4717-YC
15B E, IC, P, WB Human CBMAB-A4712-YC
RXDMC F Human, Mouse CBMAB-R3861-CN
NCOR1
7A7A9 E, IH, P, WB Human CBMAB-N1470-WJ
CBWJN-0129 E, IH, WB Human CBMAB-N1469-WJ
9BA9 E, WB Human CBMAB-1448CQ
RB1
Rb1 (1F8) IH, IF Human CBMAB-C1002-CQ
CBXC-2448 WB, P, C Human, Mouse CBMAB-C0046-CQ
CBXC-2426 WB, IF
Human, Mouse, Rat, Dog,
Primate, Rabbit
CBMAB-C0034-CQ
TBX3
CBYJT-2161 WB, IP, IF, E Human,Rat, Mouse CBMAB-T1266-YJ
CBYJT-2160 WB, IP, F Human,Rat, Mouse CBMAB-T1265-YJ
CBYJT-2158 WB, E, P, F, IC, IF Human CBMAB-T1263-YJ
PIK3R1
U5 C, IP, WB
Cattle, Human,Mouse, Non-
Human primate, Rat
CBMAB-P1817-YC
2E7 E, M Human CBMAB-0832-CN
8C11 E, WB, P, IF, IC, F Human, Mouse CBMAB-P1814-YC
CTCF
2B12E2 E, WB, IF Human, Mouse CBMAB-C4674-LY
1D11 E, WB Human, Monkey CBMAB-C3807-LY
CBXC-1870 WB, IH, P Human CBMAB-C5096-CQ
NF1
2D1 E, WB Human CBMAB-N2125-W
A-12 WB, IP, IF, P, E mouse, rat, Human CBMAB-N2129-WJ
CBWJN-0652 WB, E, IP, P
Human, Mouse, Rat, Guinea
Porcine
CBMAB-N0290-WJ
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Antibodies for
Breast Cancer Research
To be continued.

5. Popular antibodies for key markers
Creative Biolabs' antibodies help meet your breast cancer research needs and budget requirements,
increasing efficiency and offering the best value for a wide range of applications and specific assays.
ESR1
Targets Clone Applications Species reactivity Cat.No.
SF3B1
CBXS-5436 WB
Human, Mouse, Rat, Monkey,
Hamster, Cattle
CBMAB-S2647-CQ
CBXS-2265 WB, IP, IF, E Mouse, Rat, Human CBMAB-S5027-CQ
CBXS-1300 WB, P, IF Human CBMAB-S4159-CQ
AKT1
4E10 WB, IH, IF, F Human,Dog, Rat, Monkey, Mouse CBMAB-A2050-YC
4C3 E, IP, PLA, RNAi Human CBMAB-A2048-YC
5C10 E, WB Human,Mouse, Rat, Dog CBMAB-A2053-YC
CBFB
A-4 WB, IP, IF, E Human CBMAB-P0143-YC
8C84 DB, C, WB Human CBMAB-C9108-LY
1E6 IP, WB, M Human CBMAB-0194-YC
FOXA1
3C1 WB, E, P, IF Human CBMAB-F0941-CQ
2D7 E, WB, IH Human CBMAB-F2967-CQ
CBXF-3132 IC, IH, WB Human, Mouse CBMAB-F3828-CQ
CDKN1B
SX53G8 P Human,Mouse, Rat, Primate CBMAB-P0194-YC
0.N.491 F, IF, IH, IP, WB Dog, Human,Mouse, Rat CBMAB-P0188-YC
CBLC-LY-008 F, IF, C, P, IP, WB Mouse CBMAB-C9407-LY
Targets Clone Applications Species reactivity Cat.No.
ESR1
ESR1/420 WB, F, IF Human CBMAB-E0318-FY
2G112B3 E, WB Human CBMAB-1204-YC
CBFYE-1267 IC, IH, IP, WB Hamster, Human, Mouse, Rat CBMAB-E1850-FY
Antibodies for commonly mutated targets
HER2/ERBB2
Targets Clone Applications Species reactivity Cat.No.
HER2/
ERBB2
4D5-8
(TrasTuzumab)
F, E, IH, MC Human CBMAB-E1659-FY
SPM495 P, WB Human, Mouse, Rat, Monkey CBMAB-E1645-FY
9G6 F, IF, C, P, IP, WB Human CBMAB-E1648-FY
The anti-HER2 antibody shows distinct
membranous positivity in HER2-negative and
positive ductal carcinoma.
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The anti-ESR1 antibody shows obvious nuclear
positivity in human breast tissue using IHC.
By western blot analysis, ESR1 is clearly detected
around 68KDa.
Antibodies for
Breast Cancer Research

6. Targets Clone Applications Species reactivity Cat.No.
SRC
CBXS-3318 F, IC, IH, IP, WB
Cattle, Hamster, Human, Monkey,
Mouse, Rat
CBMAB-S6057-CQ
CBXS-2306 IC, IP, WB Chicken CBMAB-S5068-CQ
CBXS-1773 IH Human CBMAB-S4590-CQ
RAS
Y13-259 WB Mouse, Rat, Human CBMAB-G6077-LY
1C8 WB Human, Monkey CBMAB-G6073-LY
CBFYH-1953 WB, IH, IF Human, Dog, Rat, Monkey, Mouse CBMAB-H2964-FY
BRAF
15B239 WB Human, Mouse CBMAB-R0430-CN
CBYY-2086 IH, P, WB Human, Dog CBMAB-2435-YY
CBYY-1674 F, IC, IH, P, WB Human CBMAB-2023-YY
MEK1
25/MEK1 F Human, Chicken, Dog, Mouse, Rat CBMAB-M0108-FY
CBFYM-1441 WB, P, IF, IP Human, Mouse, Rat, Zebrafish CBMAB-M1601-FY
CBFYM-1438 WB
Dog, Human, Mouse, Non-human
primate, Rat
CBMAB-M1598-FY
Ki67
Targets Clone Applications Species reactivity Cat.No.
Ki67
3D11 IH, P, WB Human CBMAB-K2136-LY
4A1 IA, IH Human CBMAB-K2137-LY
SP6 IH, IC/IF, P, C Human, Mouse, Rat, Dog CBMAB-K2173-LY
The anti-Ki67 antibody shows obvious nuclear
positivity in human lymph node via IHC. By ICC-
IF, Ki67 is detected in nucleoli of human cell line
U-2OS.
Progesteron receptor (PGR)
Targets Clone Applications Species reactivity Cat.No.
PGR
4E9 E, IF, P, WB Human CBMAB-P1613-YC
0.N.529 IF, IH, IP, WB Equine, Human,Pig, Sheep CBMAB-P1605-YC
8A11H1 WB Human CBMAB-P1614-YC
By immunofluorescence and immunohistochemistry,
PGR is detected in MCF-7 cell and formalin-fixed
paraffin-embedded human breast cancer tissue.
Popular antibodies for key signaling factors
Key signaling pathways involved in breast cancer include RAS/RAF, RAS/MAPK, PI3K/AKT etc.
Creative Biolabs provides a wide range of antibodies for involved signaling factors, but not limited to
these. Please contact us for more products information.
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Antibodies for
Breast Cancer Research

7. Targets Clone Applications Species reactivity Cat.No.
MEK2
CBFYM-1465 WB, E, F, IF Mouse, Rat, Human CBMAB-M1625-FY
CBFYM-1456 F
Human, Chicken, Dog, Frog,
Mouse, Rat
CBMAB-M1616-FY
CBFYM-1455 F, IC, IF, WB Human CBMAB-M1615-FY
ERK1/MAP
K3
3C9 E, IC, IF, P, IP, WB Human CBMAB-1195-YC
1E5 E, P, F, IC, IF, WB Human, Mouse, Rat, Monkey CBMAB-1192-YC
12D11 WB, CI, IH, IF, P Human, Mouse, Primate CBMAB-E2167-FY
ERK2/MAP
K1
4F3-A10-E7 WB Human,Mouse, Rat CBMAB-P0477-YC
CBFYM-1574 E, WB, IH, IC Human, Mouse, Rat, Sheep CBMAB-M1740-FY
4C11 E, IC, IF, IH, C, P, WB Human, Mouse, Monkey CBMAB-1201-YC
MAP2K4
CBXS-4988 F, IF, IH, P, IP, WB Human CBMAB-S2210-CQ
CBXS-5919 F, IF, IH, P, WB Human, Dog CBMAB-S0768-CQ
CBFYM-1486 WB, IP
Human, Mouse, Rat, Monkey,
Dog
CBMAB-M1646-FY
JNK/MAPK
8
41/JNK/SAPK
(pT183/pY185)
WB Human, Mouse, Rat CBMAB-0199-WJ
H.715.7 IP, WB
Hamster, Human, Mink, Mouse,
Primate, Rat
CBMAB-0363-WJ
2F3 WB, IP, E, P Human CBMAB-0148-WJ
STMN2
CBXS-3507 E, WB Human CBMAB-S6236-CQ
CBXS-1399 WB, IP Mouse, Rat, Human CBMAB-S4257-CQ
CBXS-0804 SE, E, WB Human CBMAB-S3731-CQ
PIK3R1
8C11 E, WB, P, IF, IC, F Human, Mouse CBMAB-P1814-YC
2E7 E, M Human CBMAB-0832-CN
U13 WB, IP
Mouse, Rat, Cattle, Human,
Monkey
CBMAB-P1816-YC
PIK3R3
2F8 E, PLA, WB Human CBMAB-P1824-YC
CBYC-P386 WB, P, IC, IF Mouse, Rat, Human CBMAB-P1825-YC
AKT2
5B5 WB, IP Human,Mouse, Rat, Monkey CBMAB-A2093-YC
AW114 WB, IP Human, Rat CBMAB-A2101-YC
D16-H E, WB, IF, IC, IP Human,Mouse, Rat CBMAB-A2102-YC
PTEN
10BA33 IF, WB Human CBMAB-1516CQ
D4.3 WB, IP
Human, Mouse, Rat, Hamster,
Monkey, Dog, Chicken
CBMAB-P3310-YC
1B8 E, F, IC, IF, WB Human, Mouse CBMAB-P3306-YC
MDM2
CBFYM-1965 E, F, IC, IF, WB Mouse CBMAB-M2140-FY
CBFYM-1964 E, WB, IH Human, Mouse, Rat CBMAB-M2139-FY
CBFYM-1961 IC, IF, IH, IP, WB Human CBMAB-M2136-FY
p53
7A4 IF, IH, IP, WB Common fruit fly CBMAB-0433-LY
CBWJW-083 WB, P, PE Human, Mouse, Rat CBMAB-T0002-WJ
CBLG1-2390 IF, SE, E, WB Human CBMAB-G6398-LY
TBX3
CBYJT-2161 WB, IP, IF, E Human,Rat, Mouse CBMAB-T1266-YJ
CBYJT-2159 E, IC, WB Human CBMAB-T1264-YJ
CBYJT-2160 WB, IP, F Human,Rat, Mouse CBMAB-T1265-YJ
GSK3B
E.948.2 P, IP, WB Human, Mouse, Primate, Rat CBMAB-G5224-LY
3A11 E, WB Human, Mouse, Rat CBMAB-G0845-LY
3D6B4 WB, F, E, IH, MC Human, Mouse CBMAB-H1379-FY
Antibodies for key signaling factors in breast cancer
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Antibodies for
Breast Cancer Research
To be continued.

8. Targets Clone Applications Species reactivity Cat.No.
Cyclin
D1/CCND
1
CD1.1 WB, F, E, IH, IP, P, C Human, Rat CBMAB-C4698-CQ
SP4 WB, IH, IF, P Human, Mouse, Rat, Baboon CBMAB-C4697-CQ
CBXC-1590 E, F, IH, IP, WB Human, Rat CBMAB-C4700-CQ
Cyclin
D3/CCND
3
CBYY-C0337 WB, IH Human CBMAB-C1127-YY
CBFYC-1042 F, IF, IH, IP, N, WB Human, Mouse, Rat CBMAB-C1099-FY
CBFYC-1040 WB, IF, IH, IP Mouse, Dog, Human, Rat CBMAB-C1097-FY
CDK4
5J210 IF, IH, IP, WB Human, Mouse, Rat CBMAB-C7749-LY
3F9-B12-C8 WB, E Mouse, Rat, Dog, Human, Pig CBMAB-C6085-LY
0.N.199 IF, IP, WB Human, Mouse, Pig, Rat CBMAB-C1404-LY
PRB1/2 BA0343 WB, P Human CBMAB-0690CQ
NCOA3
AX15.3 E, IH, P, IP, WB, CI Human CBMAB-S2958-CQ
AC3 WB, IH, IF, P Human CBMAB-N0184-WJ
F-2 WB, IP, IF, E mouse, rat, Human CBMAB-N1451-WJ
MYC
9E11
WB, CI, F, E, IH, IP,
P, C, MC
Human, Mouse, Chicken, Yeast CBMAB-C9324-LY
3G32 E, IF, IH, IP, WB Human, Mouse CBMAB-C6137-LY
CT14.G4 F, IF Human, Primate CBMAB-C0609-CQ
MYB
10A3 IP, WB Human, Mouse, Zebrafish CBMAB-V0114-LY
D-12 WB, IP, IF, E Mouse, Rat, Human CBMAB-A4588-YC
4-E3 WB, IP Human, Mouse, Xenopus CBMAB-A4587-YC
FOXA1
4F6 E, IF, P, WB Human CBMAB-F2445-CQ
CBFYH-0203 WB, IP, IF, P, E Mouse, Rat, Human CBMAB-H1077-FY
SP88 F, P Human CBMAB-F0220-CQ
GATA3
1A12-1D9 IC, IF, P, IP, WB Human, Mouse, Rat CBMAB-G2217-LY
7B5 E, IH, P, WB Human CBMAB-G2223-LY
CBLG1-676 IC/IF, P, IP, WB Human CBMAB-G2244-LY
CBFB
A-4 WB, IP, IF, E Human CBMAB-P0143-YC
4D9 IP, WB, M Human CBMAB-0199-YC
CBYY-C1023 DB, IC, WB Human CBMAB-C2460-YY
RUNX1
CBYC-A1038 F Human, Monkey CBMAB-A4717-YC
15B E, IC, P, WB Human CBMAB-A4712-YC
RXDMC F Human, Mouse CBMAB-R3861-CN
NCOR1
7A7A9 E, IH, P, WB Human CBMAB-N1470-WJ
CBWJN-0129 E, IH, WB Human CBMAB-N1469-WJ
9BA9 E, WB Human CBMAB-1448CQ
TBL1XR1
CBYJT-2103 E, WB, IH, IC
Human,Mouse, Rat, Cattle, Pig,
Dog, Zebrafish
CBMAB-T1202-YJ
CBYJT-2102 WB, E, P, IC Human,Mouse CBMAB-T1201-YJ
CBYJT-2105 WB, IP, CI Human, Monkey CBMAB-T1204-YJ
p16Ink4A
/CDKN2A
5-C3-1 IF, IH, IP, WB Mouse CBMAB-C7387-LY
2D9A12 WB, P Human CBMAB-C4943-LY
1E12E10 WB, P Human, Mouse, Rat CBMAB-C3919-LY
Antibodies for key signaling factors in breast cancer
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Antibodies for
Breast Cancer Research

9. Antibody Services Guidance
Specific
Yes
What's my target?
Popular
Catalogue Ab Custom Ab
No
Suit my project
Available or not in Creative Biolabs?
Order the Catalogue Ab Online
Test the Ab
Mouse or rabbit?
Specific epitope
Batch to batch reproducibility
Monoclonal Ab Polyclonal Ab
Epitope synthesises or not?
Creative Biolabs offers comprehensive antibody products and related services. Please contact us for
more detailed information and our team will get back to you as soon as possible. We are always
here to serve you to help promote your projects. The list above only exhibits a small part of our
products. Please visit our website for more information. https://www.antibody-creativebiolabs.com
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Antibodies for
Breast Cancer Research

10. Custom Antibody Service Process
Innovative technologies and ideas
Numerous worldwide customers
High-level Ph.D. scientists and experienced technicians
High efficiency and short turnaround time
Close collaboration
Extensive forefront knowledge sharing
Advanced and one-stop platforms
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Highlight Features:
With extensive experience and over a decade superior antibody services for numerous
worldwide customers, Creative Biolabs has blossomed into a service leader in the field of
antibody products and services. We offer a comprehensive set of package services and
also individual modules, and aim to maximize the success of your breast cancer research
discovery and development.
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Delivery
Submit protein
sequence
Antigen design Antigen synthesis Antibody production
and purification
Quality control
WB IHC ELISA IP/ChIP IF/FC Functional
A wide range of
applications
assay
Antibodies for
Breast Cancer Research

11. The trusted antibody and
custom service & solution provider.
Leverage the expertise of our senior scientists to obtain
a wide array of antibodies or custom products to fit your
project.
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customer support.
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Expedite Your
Breast Cancer Research
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