Creative Biolabs is a leading service provider in the complement therapeutics field in the US. Our one-stop drug discovery platforms and experienced technicians are dedicated in helping you develop therapeutic candidates, diagnostic reagents. https://www.creative-biolabs.com/complement-therapeutics/

1. https://www.creative-biolabs.com/complement-therapeutics/
COMPLEMENT
THERAPEUTICS
Creative Biolabs offers comprehensive one-stop
services for complement therapeutics.

2. Creative Biolabs is a leading service provider in the complement
therapeutics field in the US. Our one-stop drug discovery platforms
and experienced technicians are dedicated in helping you develop
therapeutic candidates, diagnostic reagents…
We provide a broad portfolio of laboratory and manufacturing
services for complement therapeutic:
About Us
For more than 10 years,
we have been providing
the best services,
products and
communications to our
valuable customers based
on the values of quality,
timing and price.
٠ Therapeutic Antibodies
٠ Protein Antigens
٠ Soluble Complement Regulators
٠ Serine Protease Inhibitors
٠ Complement Component Inhibitors
٠ Anaphylatoxin Receptor Antagonists
…

3. Outline
C O M P L E M E N T T H E R A P E U T I C S
01
With the belief of the
customer-first principle,
we serve our global
clients with the most
reliable and qualified
results.
Introduction Indication
Services Products

4. 2011
Classical pathway involves
complement components
C1, C2 and C4, and is
triggered by antibody-
antigen complexes binding
to C1.
Alternative pathway
involves various factors, B,
D, H & I, and is initiated by
cell surface constituents
that are foreign to the
host.
Lectin pathway is
activated by the binding
of mannose-binding lectin
(MBL) to mannose
residues on the pathogen
surface.
Complement System Introduction
C O M P L E M E N T T H E R A P E U T I C S
Complement is a system of plasma proteins that can
be activated directly by pathogens or indirectly by
pathogen-bound antibody, leading to a cascade of
reactions that occur on the surface of pathogens
and generate active components with various
effector functions.
02
Complement Pathways
Classical
Pathway
Alternative
Pathway
Lectin
Pathway

5. Fig.1 Complement cascade. (Mathern, 2015)
Activation Regulation
Homeostasis
Too much activation/
Insufficient regulation
Too much regulation/
Insufficient activation
Infection
Inflammation
The intricate complement network requires rigorous regulation to maintain appropriate
homeostasis.
Complement System Regulation
C O M P L E M E N T T H E R A P E U T I C S
03

6. Cardiovascular Disease
Autoimmune Disease Nephropathy
Osteology
Genetic Disease
Infection
Neurology
Inflammatory Disease Ophthalmology
Excessive or insufficient activation will break the delicate balance
between complement activation and regulation, leading to a variety
of diseases.
Creative Biolabs provides a great variety of therapeutic antibodies,
inhibitors, soluble complement regulators, as well as customized
services to help our customer develop novel drugs for complement-
related diseases.
Complement Therapeutics Indication
C O M P L E M E N T T H E R A P E U T I C S
Complement-related Diseases
Complement Therapeutics
04

7. Technicians in Creative Biolabs’s experienced team provide complement therapeutic services ranging from therapeutic antibody, protease inhibitor, soluble complement
regulator, complement component inhibitor to anaphylatoxin receptor antagonist development. We help our clients discover novel drugs, avoid the pitfalls of variability in
assays and benefit from the efficiency and accuracy of a dedicated facility.
Complement Therapeutics Service
C O M P L E M E N T T H E R A P E U T I C S
05
Serine Protease Inhibitors Soluble Complement Regulators
Therapeutic Antibodies Complement Component Inhibitors
Anaphylatoxin Receptor Antagonists

8. • C5 Antibody Development
• CD46 (MCP) Antibody Development
• CD59 (MIRL) Antibody Development
• CD20 Antibody Development
• CD55 (DAF) Antibody Development
…
Antibody-based therapeutics appears to be the most rapidly growing
drug class against complement-related diseases. Based on the advanced
technology and rich experience, Creative Biolabs offers a comprehensive
service of therapeutic antibodies development for our clients.
OUR THERAPEUTIC ANTIBODY
DEVELOPMENT SERVICE INCLUDES:
Therapeutic Antibody Development
C O M P L E M E N T T H E R A P E U T I C S
Complement
Therapeutics
Service

9. A natural panel of highly effective complement regulators that primarily
act at the level of convertases or the terminal complement complex (TCC)
can be exploited for therapeutic purposes. We have developed an
advanced platform of soluble complement regulators services to support
your projects. Our soluble complement regulators services can be tailor-
designed to meet your specific needs and it is fast, reliable and affordable.
OUR SOLUBLE COMPLEMENT REGULATOR
DEVELOPMENT SERVICE INCLUDES:
• sCR1/TP10 Development Service
• CAB-2/MLN-2222 Development Service
• C4-binding Protein (C4BP) Development Service
• Factor H Development Service
• Factor I Development Service
…
Soluble Complement Regulator Development
C O M P L E M E N T T H E R A P E U T I C S
Complement
Therapeutics
Service

10. Inappropriate activation or regulation of complement cascade may be
destructive for host cells and is involved in lots of diseases and pathological
conditions. Modulation or inhibition of complement activity has therefore
been regarded as a promising diagnostic or therapeutic strategy. Creative
Biolabs is proud to offer a range of complement component inhibitors
development services in a timely and cost-effective manner.
OUR COMPLEMENT COMPONENT
INHIBITOR DEVELOPMENT SERVICE
INCLUDES:
• Compstain
• Aptamer
…
Complement Component Inhibitor Development
C O M P L E M E N T T H E R A P E U T I C S
Complement
Therapeutics
Service

11. Complement systems are proteolytic cascades in which serine proteases are
activated from each other by limited proteolysis in a strictly ordered manner.
Inhibition of the complement serine proteases may be an attractive therapeutic
approach. As one of the most highly respected drug discovery and antibody
development companies, Creative Biolabs provides biotherapeutics development
strategies for serine protease inhibitors including serpins, macroglobulins, and
other small protein inhibitors.
OUR SERINE PROTEASE INHIBITOR
DEVELOPMENT SERVICE INCLUDES:
• Serpins Development Service
• Macroglobulins Development Service
• Small Protein Inhibitors Development Service
…
Serine Protease Inhibitor Development
C O M P L E M E N T T H E R A P E U T I C S
Complement
Therapeutics
Service

12. Anaphylatoxins, or complement peptides, are fragments that are produced
as part of the activation of the complement system. Complement protein
C5a and C3a are the most common targets of inhibition against various
diseases and the antagonists for C5aR and C3aR have been explored as
therapeutic intervention in many diseases. Creative Biolabs provides
anaphylatoxin receptor antagonist development services against a variety
of complement component.
OUR ANAPHYLATOXIN RECEPTOR
ANTAGONIST DEVELOPMENT SERVICE
INCLUDES:
• PMX53
• SB290157
…
Anaphylatoxin Receptor Antagonist Development
C O M P L E M E N T T H E R A P E U T I C S
Complement
Therapeutics
Service

13. 05
Inhibitors
• High affinity
• High specificity
• Wide applications
• High potency
• Standardized
transportation
• Customizable
…
• Safe
• High efficiency
• Quality control
• Ready to use
• Universality
• Customizable
…
• High specificity and
sensitivity
• Quick and accurate
results
• Easily automated
• Convenient and easy-
to-use
• Low false-positive
rate
• Customizable
…
• Guaranteed quantity
• Fast synthesis
• High specificity
• User-friendly
presentation
• Customizable
…
• High purity
• High solubility
• Wide applications
• Mimetic function
• Standardized
transportation
• Customizable
…
Complement Therapeutics Products
C O M P L E M E N T T H E R A P E U T I C S
06
01
Antibodies
02
Proteins
03
Peptides
04
Assay Kits
05
Inhibitors

14. Creative Biolabs offers a series of ready-to-use antibodies targeting different components of the complement system.
These antibodies with good sensitivity and specificity are available for WB, Flow, Func, IA, ICC/IF, IHC, IHC-Fr. We
believe that our high-quality antibodies can assist your research and development project of the complement system.
Product Name Specie Reactivity Applications
Anti-Complement Component C1qA Monoclonal Antibody Human WB; Flow; Func; IA; ICC/IF; IHC
Anti-Complement Component C1r Monoclonal Antibody Human WB; IP
Anti-Complement Component C2 Monoclonal Antibody Human WB; IP; ELISA
Anti-Complement Component C3 Monoclonal Antibody Human ELISA; IF; IHC; WB
Anti-Complement Component C4 Monoclonal Antibody Human ELISA; WB
Anti-Complement Component C5 Monoclonal Antibody Human ELISA; WB
Anti-Complement Component C6 Monoclonal Antibody Human ELISA; Flow; IHC; IHC-Fr
Anti-Complement Component C7 Monoclonal Antibody Human WB; ELISA
Featured antibodies for complement therapeutics:
ANTIBODIES
C O M P L E M E N T T H E R A P E U T I C S
Complement
Therapeutics
Products

15. Creative Biolabs provides a variety of complement system-related proteins, which could be the qualified tools for
the early discovery process in life science research and groundbreaking development of specific clinical
applications. These proteins with high purity and solubility are available for WB, ELISA, PA, AP, etc.
Product Name Applications
Recombinant Human C1QB Protein-GST tag WB; ELISA; PA; AP
Recombinant Mouse C1qBP Protein-6His tag Binding Activity Assays
Recombinant Human Complement Component C1qC Protein-GST tag WB; ELISA; PA; AP
Recombinant Human C1QL1 Protein-GST tag AP; Array; ELISA; WB
Recombinant Human Complement Factor H-related 5 Protein-10His tag Bioactivity Assays
Recombinant Mouse Complement Factor P Protein-His tag WB; ELISA; IP
Recombinant Human Complement C3 Protein-GST tag WB; ELISA; PA; AP
Featured proteins for complement therapeutics:
Complement
Therapeutics
Products
PROTEINS
C O M P L E M E N T T H E R A P E U T I C S

16. Creative Biolabs provides a wide range of array kits that are considered as particularly powerful tools for studying
disease pathways, screening for potential drug candidates and evaluating biopharmaceutical production processes.
These specific array kits can detect new receptors or targets in various diseases, assess protein-protein interactions,
to quantitate the amount of target analytes or monitor protein expression levels in biological samples.
Product Name Pack Size
Human Complement C3a des Arg ELISA Kit 96 wells
Human Complement C4a des Arg ELISA Kit 96 wells
Human Complement C5a AccuSignal ELISA Kit 96 wells
Human Complement C3 ELISA Kit 96 wells
Human Complement C1q ELISA Kit 96 wells
Human Complement C1R ELISA Kit 96 wells
Human Complement C2 ELISA Kit 96 wells
Featured array kits for complement therapeutics:
ARRAY KITS
C O M P L E M E N T T H E R A P E U T I C S
Complement
Therapeutics
Products

17. Peptides are synthesized naturally from transcription of DNA and they perform a wide range of essential
functions in all manner of biological processes. Creative Biolabs provides the customers with many kinds of
different premade complement associated peptides, from which you can easily choose an optimal candidate to
help you get a milestone development.
Product Name Applications
Glutamic acid decarboxylase mAb (11) Blocking Peptide IHC; WB
Glutamic acid decarboxylase pAb Blocking Peptide IHC; WB
Heme oxygenase 1 pAb Blocking Peptide Elisa; WB
Heme oxygenase 2 pAb Blocking Peptide Elisa; WB
Complement C1q Binding Protein (CD93) Peptide ELISA; WB; IP; IHC; ICC
Complement C2 Blocking Peptide IHC; WB
Complement C1QB Blocking Peptide Blocking
Featured peptides for complement therapeutics:
PEPTIDES
C O M P L E M E N T T H E R A P E U T I C S
Complement
Therapeutics
Products

18. Why Us
• 10 years+ of exploration & development
• Full range of one-stop services for Complement Therapeutics
• Fully customizable project procedure
• Your best partner in Complement-based Drug Discovery
Service Features
• Extensive experience and advanced biotechnologies
• Fully customizable experimental design to meet your R&D timeline and budget
• Competitive price with the best quality
• Best after-sale service
07 Our Advantages

19. Contact Us
USA HQ Mailing Address:
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-466-5530
Fax: 1-631-207-8356
Email: info@creative-biolabs.com
Quality / Science / Dedication