IDEATHON contest organised by Amity University.

1. Presented by -
Shantanu Singh
MS Pharm. (Pharmacology & Toxicology)
National Institute of Pharmaceutical Education &
Research, Hajipur (NIPER-HJP)
Email: santanusingh65@gmail.com
Title-Potential Treatment of Asthma
with Natural Antioxidants
Presented To -
All Attendee's & Reviewers of IDEATHON
contest
Department of Phytomedicine &
Phytochemistry
Amity University, Lucknow
Email: subhashsaininiper@gmail.com

2. • Asthma
• Asthma is a chronic inflammatory disease of the airway associated with airway hyper
responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness
or coughing that can vary over time and in intensity
• Asthma is a serious health and socio-economic issue all over the world, affecting more than
300 million persons all over the world, with approximately 250,000 annual deaths.

3. • Treatment strategies of Asthma
Asthma
Bronchodilators
Anti-Inflammatory
drugs
β2-adrenergic agonists
Anti-cholinergic drugs
Methyl Xanthines
Leukotriene Antagonists
Mast cell stabilizers
Corticosteroids
Anti-IgE Antibody
Pulmonary Rehabilitation
Bronchial Thermoplasty
Allergen Avoidance
Pharmacological TreatmentNon-Pharmacological Treatment
Fig. Showing the Treatment Modalities of Asthma
Antioxidant Treatment

4. Dust Mites Pollens Grains
• Role of Antioxidants
in the Asthma
Pet Dander Mould Spores
Allergic stimuli
Viral Infections Air Pollution Tobacco Smoke Cold Air
Non-Allergic stimuli
Antigen-presenting cells (APCs)
Dendritic cell Macrophage cell B Cell Epithelial cells
Activation of Inflammatory Cells and Mediators
Th2 Cell Immunoglobulin E(IgE)
Mast cell
Eosinophil Neutrophils
• Interleukins (IL-3, IL-4, IL-5, IL-9, IL-17,etc)
• Tumour Necrosis Factor α(TNF-α)
• Interferon γ (IFN- γ)
• Extracellular signal-regulated kinase 1 and 2 (ERK1/2)
• Activator protein-1 (AP-1)
• Nuclear factor-κB (NF-κB)
• Granulocyte macrophage colony stimulating factor(GM-CSF)
Autacoids Oxidative & Nitrative Stress
• Histamine
• Leukotrienes
• Prostaglandins
• Cytokines
• Chemokines
• Superoxide anion
• Hydroxyl radicals
• Hydrogen peroxide
• Hypochlorous acid
• Hydroperoxyl
Chronic Inflammation of Airway
• Bronchoconstriction
• Mucus Hypersecretion
• Angiogenesis
• Cholinergic reflex
• Sensory Nerve Activation
• Sub-Epithelial Fibrosis
• Smooth Muscle Hyperplasia
• Tissue remodelling
• Plasma Leakage Edema
• Neuronal remodelling
Asthma
• Nitric Oxide (NO)
• NO synthase I(nNOS)
• NO synthase II(iNOS)
• NO synthase III(eNOS)
• Peroxynitrite
Fig. Showing the brief Pathogenesis of Asthma
Natural
Antioxidants
• Aerva lanta linn (Amaranthaceae)
• Bacopa monnieri (Schrophulariaceae)
• Cnidium monnieri (Umbelliferae)
• Eclipta alba Linn (Asteraceae)
• Lepidium sativum Linn (cruciferae)
• All these Natural herbs have
potential Antioxidant property for
the treatment of Asthma.

5. • Recent Researches / Clinical trials
• Malar J, Chairman K, Singh ARJ, Vanmathi JS, Balasubramanian A, Vasanthi K. Antioxidative activity of different
parts of the plant Lepidium sativum Linn. Biotechnol Rep (Amst). 2014 Jun 4;3:95-98. doi:
10.1016/j.btre.2014.05.006. PMID: 28435800; PMCID: PMC5374141.
• Yadav NK, Arya RK, Dev K, Sharma C, Hossain Z, Meena S, Arya KR, Gayen JR, Datta D, Singh RK. Alcoholic Extract
of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxid
Med Cell Longev. 2017;2017:9094641. doi: 10.1155/2017/9094641. Epub 2017 Jan 31. PMID: 28250894; PMCID:
PMC5307245.
• Sun Y, Yang AWH, Lenon GB. Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology of Cnidium
monnieri (L.) Cusson. Int J Mol Sci. 2020 Feb 3;21(3):1006. doi: 10.3390/ijms21031006. PMID: 32028721; PMCID:
PMC7037677.
• Taur DJ, Patil RY. Some medicinal plants with antiasthmatic potential: a current status. Asian Pac J Trop Biomed.
2011 Oct;1(5):413-8. doi: 10.1016/S2221-1691(11)60091-9. PMID: 23569804; PMCID: PMC3614196.

6. Special thanks to Dr. Subhash Chander (Asst. Professor Amity
University) and Amity Institute of Phytomedicine &
Phytochemistry (AIP & P) for Organizing the IDEATHON contest
and making resources available for presenting my Innovative
idea.
• Credits

7. Thank
You!