8. Cinnamon extract
improves fasting blood
glucose and glycosylated
hemoglobin level in
Chinese patients with type
2 diabetes.
Hypothesis:
Is Cinnamon effective in
improving blood glucose
control in Chinese patients with
type 2 diabetes?
9. Methodology:
66 Patients with type 2 diabetes.
divide the patients into 3 groups (placebo, low-dose, high-dose
of supplementation with cinnamon extract) took Gliclazide
during the entire three month of study.
Result:
1)Both hemoglobin A1c and fasting blood glucose levels were
significantly reduced in patients in the low- and high-dose
groups, whereas they were not changed in the placebo group.
2)The blood triglyceride levels were also significantly reduced in
the low-dose group. The blood levels of total cholesterol, high
density lipoprotein cholesterol, low-density lipoprotein
cholesterol, and liver transaminase remained unchanged in the 3
groups.
10. Conclusion:
This study indicates that cinnamon
supplementation is able to significantly improve
blood glucose control in Chinese patients with
type 2 diabetes.
11. Cinnamon improves insulin sensitivity and alters the
body composition in an animal model of the
metabolic syndrome.
Aim of the study:
To determine the effects of Cinnamon (CN) on insulin resistance
and body composition, using an animal model of the metabolic
syndrome, the high fat/high fructose (HF/HF) fed rat.
Methodology:
Four groups of 22 male Wistar rats were fed for 12 weeks with:
(HF/HF) diet to induce insulin resistance,
HF/HF diet containing 20 g cinnamon/kg of diet (HF/HF + CN),
Control diet (C) and
Control diet containing 20 g cinnamon/kg of diet (C + CN).
12. Result:
1. Data from hyper-insulinemic euglycemic clamps showed a
significant decrease of the glucose infusion rates in rats fed the
HF/HF diet.
2. Addition of cinnamon to the HF/HF diet increased the glucose
infusion
3. rates to those of the control rats.
4. The HF/HF diet induced a reduction in pancreas weight which
was prevented in HF/HF + CN group.
5. Mesenteric white fat accumulation was observed in HF/HF rats
vs. control rats This deleterious effect was alleviated when
cinnamon was added to the diet.
In summary: these results suggest that in animals
fed a high fat/high fructose diet to induce
insulin resistance ,CN alters body composition
in association with improved insulin sensitivity.