This document discusses cervical cancer. It begins by defining cervical cancer and noting that it is a common cause of death in developing countries. It occurs most often in younger women of childbearing age. Risk factors include HPV infection, multiple sexual partners, smoking, early sexual activity, and poor hygiene. Symptoms can include abnormal bleeding or discharge. Screening involves Pap smears and biopsies, while treatment options are cone biopsies, hysterectomies, radiation, and chemotherapy. The document provides details on the histological classification and diagnostic evaluation of cervical cancer.

1. By:
Sameen Jawed
Roll no: 66
4th year, 8th Semester

2. Portio vaginalis or
ectocervix
Ectocervix's
opening is called
the external os
Endocervical
canal
The endocervical
canal terminates
at the internal os
Transformation
zone

3.  Malignant neoplasm arising from the
cells originating in cervix uteri
 Common cause of death in developing
countries
 Occur in younger
women in child
bearing age

4.  Human papillomavirus (HPV) infection &
STDs
 Having many Sexual partners
 Smoking, alcohol, drug abuse
 Taking birth control pills
 Engaging in early sexual contact
 Multiparity with poor birth spacing
 Poor personal hygiene & socioeconomic
status
 Exposure to smegma

5.  Post coital vaginal bleeding
 Vaginal bleeding after menopause or
between periods
 Foul smelling watery discharge or
bloody vaginal discharge
 Pelvic pain
 Pain during coitus

6.  Cervical dysplasia leading to:
 CIN
 HSIL

8.  Squamous cell carcinoma (epidermoid carcinoma)
› Keratinising (well differentiated and moderately differentiated)
› non keratinising (large and small cell types)
› Spindle cell carcinoma
 Adenocarcinoma endocervical type
› Variant : adenoma malignum (minimal deviation carcinoma)
› Variant :villoglandular papillary adenocarcinoma
 Endometrioid adenocarcinoma
 Clear cell adenocarcinoma
 Serous adenocarcinoma
 Mesonephric adenocarcinoma
 Intestinal type (signet ring) adenocarcinoma
 Other epithelial tumours
› Adenosquamous carcinoma
› Adenoid cystic carcinoma
 Small cell carcinoma
 Undifferentiated carcinoma
 Metastatic tumours (breast, ovary, colon, and direct spread of endometrial
carcinoma)
Biblo: http://www.eurocytology.eu

11.  Lab test
Pap smear
Schiller’s iodine test
 Tissue sampling
Biopsy
 Cervical Examination
Colposcopy
Colpography

12.  Cone Biopsy
 Hysterectomy with lymph node
dissection
 Irradiation & Chemotherapy