Hyperthermia cancer treatment Rupon Bhowmik Dept of Medical physics & biomedical engineering,dhaka

1. Hyperthermia Cancer
Treatment
NAME :RUPON BHOWMIK

2.  Overview
• What is Hyperthermia ?
• How is hyperthermia used to treat cancer ?
• What are the method’s use of hyperthermia cancer treatment ?
• Treatment planning and simulation process of Hyperthermia
cancer treatment.
• Hyperthermia Equipment
• Side Effect Of Hyperthermia cancer treatment
• Hyperthermia in combination with other modalities
• Advantage and Disadvantage of Hyperthermia cancer treatment
• Conclusion
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3. What is Hyperthermia ?
• Hyperthermia (also called thermal therapy or thermotherapy) is a type of cancer
treatment in which body tissue is exposed to high temperatures (up to 113°F).
Research has shown that high temperatures can damage and kill cancer cells,
usually with minimal injury to normal tissues.
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4.  How is hyperthermia used to treat cancer ?
• Hyperthermia is almost always used with other forms of cancer therapy, such as
radiation therapy and chemotherapy. Hyperthermia may make some cancer
cells more sensitive to radiation or harm other cancer cells that radiation cannot
damage. When hyperthermia and radiation therapy are combined, they are
often given within an hour of each other. Hyperthermia can also enhance the
effects of certain anticancer drugs.
• Numerous clinical trials have studied hyperthermia in combination with
radiation therapy and/or chemotherapy. These studies have focused on the
treatment of many types of cancer, including sarcoma, melanoma, and cancers
of the head and neck, brain, lung, esophagus, breast, bladder, rectum, liver,
appendix, and cervix .
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5. What are the method’s use of hyperthermia cancer treatment ?
• Depending on the organ bearing the cancerous tissue three kinds of hyperthermia
techniques are recognized these types are-
 Local Hyperthermia- In local hyperthermia, heat is applied to a small area, such as a
tumor, using various techniques that deliver energy to heat the tumor. Depending on
the tumor location, there are several approaches to local hyperthermia:
External approaches are used to treat tumors that are in or just below the skin.
Intraluminal or endocavitary methods may be used to treat tumors within or near body
cavities.
Interstitial techniques are used to treat tumors deep within the body, such as brain
tumor.
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6. What are the method’s use of hyperthermia cancer treatment ?
Regional Hyperthermia- In regional hyperthermia, various approaches may be
used to heat large areas of tissue, such as a body cavity, organ, or limb.
 Deep tissue approaches may be used to treat cancers within the body, such as
cervical or bladder cancer .
 Regional perfusion techniques can be used to treat cancers in the arms and
legs, such as melanoma .
 Continuous hyperthermic peritoneal perfusion (CHPP) is a technique used to
treat cancers within the peritoneal cavity.
Whole-body hyperthermia is used to treat metastatic cancer that has spread
throughout the body. This can be accomplished by several techniques that raise
the body temperature to 107-108°F, including the use of thermal chambers
(similar to large incubators) or hot water blankets.
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7. Treatment planning and Simulation Process of Hyperthermia
Cancer Treatment ?
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8. Hyperthermia Equipment
2 . Regional Microwave1 . Microwave
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9. Side Effect Of Hyperthermia
• The possible side effects of hyperthermia depend of the technique being used and
the part of the body being treated. Pain, thermal burns or blisters are the limiting
adverse events of the techniques .
• In case of thermo chemotherapy ( TCHT) during the first days after the main
treatment, the occurrence of fever up to 39 °C can be observed as an expression of a
strong immunostimulation and is desirable in most cases. At this time though,
exhaustion,weakness, nausea, vomiting, headaches, diarrhoea and herpes labialis
(blisters on the lips) can also occur .
• During the TCHT main treatment, a moderate anaesthesia is given. The patient is
unable to drive for at least three days after the main treatment. In the following days,
due to various reasons (e.g. after-effects of the chemotherapy or additional
medications), reaction times can be deteriorated and, therefore, driving ability is
considerably limited. Most of these side effects are temporary .
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10. Hyperthermia in combination with other modalities
• As an adjunct to traditional cancer therapy, hyperthermia has been shown to enhance cytotoxicity of
chemotherapy agents. Since adequate heating of the whole tumor volume is difficult except for
superficially located small tumors, and in general the reported response duration is short, the use of
hyperthermia alone is not recommended .
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11. Advantage and Disadvantage of Hyperthermia cancer treatment
• The major advantage of regional and whole-body hyperthermia is that they
seem to make other forms of cancer treatment work better. Heating cancer
cells to temperatures above normal makes them easier to destroy using
radiation and certain chemotherapy drugs.
• For the success of hyperthermia therapy is very important careful
temperature control. Scientists almost unanimously agree that hyperthermia
works best when for a certain period of time to maintain a stable temperature
of the target site. But to achieve this is not always easy. Currently there is no
way to accurately measure the temperature inside the tumor. Maintain a
constant temperature, without affecting the surrounding tissue, it is also very
difficult. In addition, not all tissues in the body react to the rise in temperature
the same way - in some areas of the tissue is more sensitive than others. For
example, the brain is very sensitive to heat.
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12. Conclusion
• Although basically an old and historic approach for treatment of cancer,
hyperthermia is not a well-known modality among patients and medical experts.
On the other hand, it has proved a very successful therapy method in
combination with radiation therapy and / or chemotherapy.
• Hyperthermia is currently under study in many clinical trials, particularly in
Europe, Japan and the US, to improve and better understand this promising
technique. Future areas of challenge and opportunity for hyperthermia include:
improved understanding of thermal biology; improved technologies for delivery
and monitoring of heat treatments in patients; successful high-quality clinical
trials; and combination of hyperthermia with emerging cancer therapies .
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13. Reference
• www.intechopen.com
• http://womenhealthneten.bitballoon.com/oncology19/advantages-and-
disad5335.html
• https://en.wikipedia.org/wiki/Hyperthermia_therapy
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14. Thank you for your Attention
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