Felix Navarro - Hyperthermia

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GenesisCareUK

The effects of hyperthermia within oncology.

Healthcare

Hyperthermia in Oncology
Félix Navarro Guirado
Medical Physicist
Engineer

Page 2
Content
1) What is it?
2) What for?
3) Clinical evidence?
4) How?
5) Around the world?
Hyperthermia

Page 3
Hyperthermia
1) Heat up tumors up to 41 ºC – 45 ºC (106 ºF – 113 ºF)
2) Non ablative
3) Boosting therapy for CT / RT
What is it?
What is it NOT?
Stand alone therapy

Page 4
Content
1) What is it?
2) What for?
3) Clinical evidence?
4) How?
5) Around the world?
Hyperthermia

Page 5
Hyperthermia What for?
RT/CT target: DNA DAMAGE
Int J Hypert 2012, 28(6):509-517
Who does perform DNA repair process?
How?

Hyperthermia What for?
Mechanism of radiosensitization by hyperthermia as derived from studies with DNA repair defective mutant cell lines. Kampinga HH et al.,
INT. J. HYPERTHERMIA VOL. 20, NO.2(MARCH 2004), pp. 131–139
Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all.
Oei AL et al.,
Radiat Oncol. 2015 Aug 7;10:165.
Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1 degrees C and its effect on DNA repair. Xu M. et al.
Int J Hyperthermia. 2002 Sep-Oct;18(5):385-403

Hyperthermia What for?
Dynamics of Cell Membrane Permeability Changes at Supraphysiological Temperatures.
J. C. Bischof,et al. Biophys J. 1995(68): 2608-2614
Membrane Effects of Ionizing Radiation and Hyperthermia.
Int J Rad Biol on Physics, Chemistry & Med. 1995 49(5):743-770
Int J Hyperthermia 2013. 29(6):528-538

Hyperthermia What for?
Hyperthermia effects:
1. DNA repair inhibition
2. Drug uptake improvement
3. Abscopal effect enhancement (HSP70Antigen collector)
4. Hypoxic volume reduction
5. Cell cycle redistribution

Page 10
Content
1) What is it?
2) What for?
3) Clinical evidence?
4) How?
5) Around the world?
Hyperthermia

Page 11
Hyperthermia
2015 Impact Factor: 3.361
8 Issues/year since 1985
Ranking: 37/125 Radiology
83/213 Oncology

Hyperthermia
Adding hyperthermia to the standard treatment has been proved to improve
respone ratio: (Level 1)
- Advanced Cervix(van der Zee 2000)
- Breast recurrency (Vernon 1996, Jones 2005)
- Soft tissue sarcoma(Issels 2008)
- H&N recurrency (Valdagni 1994)
- Advanced bladder cancer (Colombo 2003)
- Anus (Kouloulias 2005)
- Cell tumours (Wessalowski 1998)

Page 14
Content
1) What is it?
2) What for?
3) Clinical evidence?
4) How?
5) Around the world?
Hyperthermia

Page 18
Content
1) What is it?
2) What for?
3) Clinical evidence?
4) How?
5) Around the world?
Hyperthermia

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Felix Navarro - Hyperthermia

1. Hyperthermia in Oncology Félix Navarro Guirado Medical Physicist Engineer

2. Page 2 Content 1) What is it? 2) What for? 3) Clinical evidence? 4) How? 5) Around the world? Hyperthermia

3. Page 3 Hyperthermia 1) Heat up tumors up to 41 ºC – 45 ºC (106 ºF – 113 ºF) 2) Non ablative 3) Boosting therapy for CT / RT What is it? What is it NOT? Stand alone therapy

4. Page 4 Content 1) What is it? 2) What for? 3) Clinical evidence? 4) How? 5) Around the world? Hyperthermia

5. Page 5 Hyperthermia What for? RT/CT target: DNA DAMAGE Int J Hypert 2012, 28(6):509-517 Who does perform DNA repair process? How?

6. Hyperthermia What for?

7. Hyperthermia What for? Mechanism of radiosensitization by hyperthermia as derived from studies with DNA repair defective mutant cell lines. Kampinga HH et al., INT. J. HYPERTHERMIA VOL. 20, NO.2(MARCH 2004), pp. 131–139 Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. Oei AL et al., Radiat Oncol. 2015 Aug 7;10:165. Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1 degrees C and its effect on DNA repair. Xu M. et al. Int J Hyperthermia. 2002 Sep-Oct;18(5):385-403

8. Hyperthermia What for? Dynamics of Cell Membrane Permeability Changes at Supraphysiological Temperatures. J. C. Bischof,et al. Biophys J. 1995(68): 2608-2614 Membrane Effects of Ionizing Radiation and Hyperthermia. Int J Rad Biol on Physics, Chemistry & Med. 1995 49(5):743-770 Int J Hyperthermia 2013. 29(6):528-538

9. Hyperthermia What for? Hyperthermia effects: 1. DNA repair inhibition 2. Drug uptake improvement 3. Abscopal effect enhancement (HSP70Antigen collector) 4. Hypoxic volume reduction 5. Cell cycle redistribution

10. Page 10 Content 1) What is it? 2) What for? 3) Clinical evidence? 4) How? 5) Around the world? Hyperthermia

11. Page 11 Hyperthermia 2015 Impact Factor: 3.361 8 Issues/year since 1985 Ranking: 37/125 Radiology 83/213 Oncology

12. Hyperthermia Adding hyperthermia to the standard treatment has been proved to improve respone ratio: (Level 1) - Advanced Cervix(van der Zee 2000) - Breast recurrency (Vernon 1996, Jones 2005) - Soft tissue sarcoma(Issels 2008) - H&N recurrency (Valdagni 1994) - Advanced bladder cancer (Colombo 2003) - Anus (Kouloulias 2005) - Cell tumours (Wessalowski 1998)

13. Hyperthermia

14. Page 14 Content 1) What is it? 2) What for? 3) Clinical evidence? 4) How? 5) Around the world? Hyperthermia

15. Hyperthermia

16. Hyperthermia

17. Page 18 Content 1) What is it? 2) What for? 3) Clinical evidence? 4) How? 5) Around the world? Hyperthermia

18. Hyperthermia

19. Hyperthermia

20. Hyperthermia

21. Thank-you