3. Prostate Hyperplasia (PH)
PH is the most common condition seen in
dogs. It is a non-malignant increase in the size
of the prostate gland related directly to the
influence of the hormone testosterone.
5. Pathophysiology
• Hyperplastic process
• Earliest sign : micro-nodule formation in
transitional zone – lateral lobes (mixture of
stromal cell and epithelial component ) and in
periurethral region – median lobe within the
smooth muscle collar of the preprosthatic
sphincter (mainly connective tissue)
• Further coalescence and growth of
micronodule become macronodule
6. Symptoms
• Bloody discharge from
urethra
• Blood in urine
• Urinating frequently
• Blood in ejaculate
• Difficulty in urination
• Difficulty with defecation
• Ribbon like stools
9. PH Vs Prostatic Neoplasia
PH Prostatic neoplasia
Most common prostatic disorders Rare
50-95% by 4-9 years of age 0.2-0.6% in dog
Androgen dependent Non-Androgenic
Benign malignant
No tumor present Tumor has necrotic center
Only intact male dogs Neutered and intact male dogs
10. Diagnosis
A rectal exam will confirm the presence of an
enlarged prostate gland.
Blood work, urinalysis, x-rays, an ultrasound,
a urine culture and microscopic evaluation of
fluid drawn from the prostate gland can help
confirm the diagnosis.
In diagnosing BPH, it's important to rule out
other causes of an enlarged prostate,
including cysts, infection with inflammation
and cancer
11.
12. Treatment
Castration
Synthetic Steroid drug such as Delmadione
acetate
Antiandrogens including flutamide ,
finasteriod & formestane may reduce
the stimulation effect of testosterone
Pumpkin seed , natural vitamin E
& selenium can all be beneficial in
regulating PH in dogs.
Estrogen & Progesteron
13. Living and management
Prostate Hyperplasia is an age-related problem
and castration is the best method for avoiding or
treating this problem in dogs.