it is novel drug delivery system important for all pharmacy students for research purpose

1. Prepared By
Miss. Mane Deshmukh P.P.
Guided By
Mrs. Barhate A.N.
SVPM’S COLLEGE OF PHARMACY
MALEGAON (BK)
1

2.  Introduction
 Definition
 Formation of liposome
 Structural components
 Composition of liposomes
 Classifications
 Advantages & disadvantages
 Preparation methods
 Limitations of liposomes technology
 Characterization of liposomes
 Applications
 Marketed Preparations
 References
2

3. INTRODUCTION
3

4. Definition 1,16:-
“Liposomes are defined as structure consisting of
one or more concentric spheres of lipid bilayers separated by
water or aqueous buffer compartments”.
4

5. FORMATION OF LIPOSOME s 19,20 :-
5

6. STRUCTURALCOMPONENT 3,12-13:-
6

7.  Phospholipids
 Sphigolipids
 Cholesterols
 Polymer material
 Polymer lipids Bearing
 Cationic lipids
 Other substance
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8. CLASSIFICAT ION 8-18 :-
8

9. 9

10. Classes of Liposomes 12 :-
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11. 11

12.  It should be biodegradable, biocompatible, and
flexible. It can carry both water and lipid soluble
drugs.
 The drugs can be stabilized from oxidation.
 It should be improve the protein stabilization.
 It provides controlled hydration,sustained release,
targeted drug delivery or site specific drug
delivery.
 Stabilization of entrapped drug from hostile
environment.
 Alter pharmacokinetics and pharmacodynamics
of drugs.
 It can be administered through various routes.
 It can incorporate micro and macro molecules
Advantages 10-18 :-
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13.  It has stability
 It has solubility
 It has short half life
 The phospholipids undergoes
oxidation, hydrolysis
 Leakage and fusion
 It is high production cost
 Some time allergic reactions
may occur to liposomal
constituents
Disadvantages 10-18 :-
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14. PREPARATION METHODS 1-8,12-16 :-
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15. 15

16. 2
16

17. MECHANICAI DISPERSIONMETHOD:
17

18. 18

19. FREEZE THAWSONICATION(FTS):-
19

20. SOLVANT DISPERSION METHOD:-
20

21. 21

22. 22

23. LIMITATIONS OF LIPOSOMES TECHNOLOGY (15) :-
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24. 24

25. 25

26. 26

27. 27

28. 28

29. 29

30. 30

31. CHARACTERIZATION 11-13:-
31

32. 32

33. APPLICATIONS:-
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34. 34

35. MARKETED PREPRATION21-22 :-
35

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form design, 2002, 2nd edit.
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delivery : Novel carrier system”. CBS publishers and
distributors, 2007.
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delivery system,8th edi.
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37. 5) Lidgate DM, Felgner PL, In vitro and in vivo studies
evaluating a liposome system for drug solubilisation. Pharm
Res 1988; 5: 759–764.
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38. 9) Barain, H. & Montazer, M,A Review on Applications
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39. 14) Harashima, H., Sakata, K., Funato, K., Kiwada, H.,
1994.Enhanced hepatic uptake of liposomes through
complement activation depending on the size of
liposomes.Pharm. Res. 11,402-406.
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limitation. Int j pharm. 1997; 154;123-140.
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464
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40. 18) Shashi K., Satinder K, Bharat P. A Complete
Review on Liposomes. Int Res J Pharm 2012;3(7)
10-16
19) Lasic D. Mechanism of liposome formation
Journal of liposome research. 1995; 5(3); 431-441.
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21)www.slideshare.com
22) www.authorstream.com
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