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        Ki-67 for further classification of triple negative breast cancer

        Triple negative breast cancer (TNBC) demonstrates poor prognosis because of aggressive
        tumor biology and lack of targeted agents.
        TNBC with high Ki-67 was associated with a more aggressive clinical feature despite a higher
        pCR rate. Ki-67 can be used for further classification of TNBC into two subtypes with different
        prognosis. Our report suggests that TNBC with residual disease and high Ki-67 expression
        should be a candidate for additional postoperative treatment such as platinum-based
        chemotherapy, or clinical trials specifically testing novel therapies in order to improve the
        outcome for this high-risk group of patients. In addition, TNBC with high Ki-67 should be
        followed-up more frequently within 3 years to guard for any recurrence

        Bibliographic Reference:
        Keam B et al.: "Ki-67 can be used for further classification of triple negative breast cancer
        into two subtypes with different response and prognosis", Breast Cancer Res. 2011 Mar 2;13
        (2):R22. [Epub ahead of print]

        Bhumsuk Keam
        Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea




http://www.senology.org/Edit_Keam.htm                                                                     03/05/2011

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Edit keam

  • 1. Editoriale Page 1 of 1 Ki-67 for further classification of triple negative breast cancer Triple negative breast cancer (TNBC) demonstrates poor prognosis because of aggressive tumor biology and lack of targeted agents. TNBC with high Ki-67 was associated with a more aggressive clinical feature despite a higher pCR rate. Ki-67 can be used for further classification of TNBC into two subtypes with different prognosis. Our report suggests that TNBC with residual disease and high Ki-67 expression should be a candidate for additional postoperative treatment such as platinum-based chemotherapy, or clinical trials specifically testing novel therapies in order to improve the outcome for this high-risk group of patients. In addition, TNBC with high Ki-67 should be followed-up more frequently within 3 years to guard for any recurrence Bibliographic Reference: Keam B et al.: "Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis", Breast Cancer Res. 2011 Mar 2;13 (2):R22. [Epub ahead of print] Bhumsuk Keam Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea http://www.senology.org/Edit_Keam.htm 03/05/2011