Assessing fruit maturity and physiological ripeness to inform picking decisions too often relies on subjective processes. Through the implementation of thorough sampling, relevant analysis, and a more holistic understanding of fruit development during the growing season, producers can harvest with more confidence that they have made the correct decisions regarding picks. The panel will discuss sampling protocols for more statistically meaningful vineyard data, viticultural signs such as berry development and canopy senescence, picking for logistical considerations vs. picking for perfection, and best lab practices for sample processing and appropriate analysis.