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Support to the Republic of Kazakhstan in Infectious Disease Prevention and
Control
is a project funded by the European Union.	
  
	
  
Developing	
  a	
  Program	
  to	
  Prevent	
  Device-­‐associated	
  Infections	
  	
  
Background:	
  	
  The	
  countries	
  of	
  Central	
  Asia,	
  as	
  those	
  of	
  much	
  of	
  the	
  former	
  Soviet	
  Union,	
  have	
  suffered	
  
from	
  an	
  under-­‐recognized	
  incidence	
  of	
  health	
  care-­‐acquired	
  bloodborne	
  pathogens,	
  most	
  commonly	
  
HIV	
  and	
  hepatitis	
  C.	
  	
  These	
  have	
  long	
  been	
  recognized	
  and,	
  although	
  the	
  exact	
  magnitude	
  of	
  them	
  is	
  
uncertain,	
  they	
  remain	
  despite	
  sporadic	
  efforts	
  to	
  end	
  the	
  practices	
  that	
  lead	
  to	
  them.	
  	
  The	
  practices,	
  
including	
  reuse	
  of	
  health	
  care	
  instruments	
  and	
  devices,	
  likely	
  persist	
  because	
  Central	
  Asia	
  is	
  “caught”	
  
between	
  newest	
  technologies	
  and	
  not	
  sufficient	
  resources	
  or	
  knowledge	
  to	
  use	
  these	
  correctly.	
  	
  The	
  
existence	
  of	
  these	
  practices	
  clearly	
  places	
  patients	
  at	
  risk	
  of	
  life-­‐threatening	
  illness	
  and	
  health	
  care	
  
personnel	
  and	
  institutions	
  in	
  morally	
  perilous	
  positions.	
  	
  EUNIDA	
  and	
  GIZ	
  have	
  proposed	
  a	
  program	
  to	
  
target	
  health	
  care-­‐associated	
  HIV	
  and	
  hepatitis	
  virus	
  infection.	
  	
  	
  
The	
  practices	
  that	
  lead	
  to	
  these	
  infections	
  can	
  be	
  placed	
  into	
  two	
  categories:	
  	
  1)	
  transfusion	
  practices;	
  
and,	
  2)	
  device-­‐associated	
  infections	
  (DAIs).	
  	
  The	
  first	
  is	
  a	
  specialized	
  area	
  and	
  other	
  programs	
  are	
  
addressing	
  it;	
  EUNIDA/GIZ	
  propose	
  addressing	
  the	
  second	
  category.	
  
DAIs	
  can	
  be	
  placed	
  into	
  two	
  categories:	
  	
  1)	
  bloodborne	
  pathogens,	
  e.g.,	
  HIV,	
  hepatitis	
  B	
  and	
  C;	
  and,	
  2)	
  
nonbloodborne	
  pathogens	
  associated	
  with	
  devices,	
  e.g.,	
  Staphylococcus	
  aureus.	
  	
  	
  The	
  frequency	
  of	
  the	
  
second	
  category	
  of	
  infection	
  is	
  undetermined.	
  	
  Although	
  EUNIDA	
  and	
  GIZ	
  focus	
  on	
  the	
  first	
  category,	
  we	
  
propose	
  addressing	
  both	
  categories	
  of	
  infection.	
  	
  This	
  makes	
  sense	
  because	
  if	
  devices	
  are	
  used	
  
appropriately,	
  then	
  both	
  types	
  of	
  infections	
  will	
  be	
  prevented.	
  	
  We	
  therefore	
  propose	
  a	
  program	
  to	
  
address	
  the	
  proper	
  use	
  and	
  care	
  of	
  devices.	
  
We	
  define	
  a	
  “device”	
  as	
  one	
  that	
  is	
  parenteral,	
  that	
  is	
  invasive,	
  and	
  which	
  might	
  lead	
  to	
  bloodborne	
  
pathogen	
  transmission.	
  	
  These	
  devices	
  might	
  be	
  called	
  intravascular	
  but	
  some	
  will	
  be	
  intramuscular,	
  
e.g.,	
  injections.	
  	
  They	
  have	
  the	
  common	
  feature	
  of	
  being	
  associated	
  with	
  blood.	
  	
  While	
  some	
  
instruments	
  can	
  conceivably	
  transmit	
  bloodborne	
  infections,	
  e.g.,	
  colonoscopy	
  instruments,	
  we	
  shall	
  not	
  
address	
  such	
  “devices”	
  nor	
  the	
  cleaning	
  and	
  sterility	
  procedures	
  that	
  must	
  be	
  performed	
  to	
  reuse	
  them.	
  	
  
Rather,	
  we	
  shall	
  address	
  devices	
  that	
  are	
  associated	
  with	
  blood	
  and	
  are	
  typically	
  supplied	
  by	
  
manufacturers	
  in	
  sterile	
  packaging	
  and	
  not	
  meant	
  for	
  reuse.	
  	
  So,	
  we	
  include	
  peripheral	
  venous	
  
catheters,	
  intraarterial	
  catheters,	
  subclavian	
  catheters,	
  etc.	
  	
  The	
  types	
  of	
  devices	
  used	
  is	
  also	
  uncertain.	
  	
  
Subclavian	
  catheters	
  appear	
  to	
  be	
  commonly	
  used	
  and	
  are	
  often	
  implicated	
  in	
  recognized	
  outbreaks	
  of	
  
HIV.	
  	
  They	
  are,	
  thus,	
  a	
  focus	
  of	
  our	
  program.	
  
Associated	
  paraphernalia,	
  e.g.,	
  multidose	
  vials	
  or	
  one	
  liter	
  IV	
  bags	
  of	
  fluid	
  (which	
  may	
  be	
  shared	
  among	
  
patients,	
  particularly	
  in	
  pediatric	
  hospitals)	
  are	
  also	
  sources	
  of	
  infection	
  and	
  for	
  which	
  no	
  guidelines	
  on	
  
use	
  exist.	
  	
  	
  
	
  Approach	
  to	
  our	
  program:	
  	
  	
  Devices	
  are	
  undoubtedly	
  overused,	
  although	
  there	
  are	
  no	
  guidelines	
  in	
  
Kazakhstan	
  on	
  when	
  to	
  use	
  them.	
  	
  A	
  recent	
  “injection	
  safety”	
  assessment	
  included	
  an	
  assessment	
  of	
  the	
  
use	
  of	
  devices	
  and,	
  while	
  not	
  quantifying	
  how	
  commonly	
  they	
  are	
  used,	
  found	
  that	
  both	
  doctors	
  and	
  
 
	
  
	
  
	
  
	
  
	
  
	
  
	
  
	
  
	
  
Support to the Republic of Kazakhstan in Infectious Disease Prevention and
Control
is a project funded by the European Union.	
  
	
  
nurses	
  thought	
  that	
  they	
  were	
  used	
  only	
  in	
  appropriate	
  instances.	
  	
  It	
  is	
  likely	
  that	
  Central	
  Asia	
  doctors	
  
and	
  nurses	
  believe	
  that	
  devices	
  should	
  be	
  used	
  more	
  often	
  than	
  Western	
  counterparts.	
  
We	
  believe	
  that,	
  despite	
  the	
  EUNIDA/GIZ	
  mandate	
  to	
  target	
  nurses,	
  any	
  program	
  to	
  prevention	
  DIAs	
  
must	
  involve	
  doctors.	
  	
  Doctors	
  hold	
  the	
  power	
  in	
  health	
  care	
  institutions	
  and,	
  unless	
  they	
  support	
  
reforms,	
  any	
  program	
  targeting	
  only	
  nurses	
  will	
  achieve	
  minimal	
  results.	
  	
  Thus,	
  we	
  propose	
  a	
  program	
  
targeting	
  the	
  safe	
  use	
  of	
  devices	
  and	
  the	
  appropriate	
  use	
  of	
  devices.	
  
An	
  intervention	
  must	
  target	
  not	
  only	
  knowledge	
  of	
  the	
  health	
  care	
  staff	
  but	
  also	
  culture	
  of	
  the	
  
institutions	
  and	
  staff.	
  	
  Achieving	
  change	
  of	
  culture	
  will	
  require	
  not	
  only	
  written	
  materials	
  but	
  verbal	
  
interaction.	
  	
  Targeted	
  would	
  be	
  not	
  only	
  decision-­‐makers,	
  largely	
  doctors,	
  but	
  opinion-­‐leaders,	
  largely	
  
respected	
  physicians/leaders.	
  	
  	
  Symposia	
  as	
  well	
  as	
  individual	
  or	
  small	
  group	
  meetings	
  will	
  be	
  
appropriate.	
  
	
  Ultimately,	
  clinical	
  practice	
  guidelines	
  (the	
  Prikaz)	
  will	
  be	
  needed	
  and	
  these	
  can	
  be	
  based	
  on	
  the	
  
materials	
  we	
  shall	
  devise.	
  	
  	
  
Our	
  materials	
  can	
  be	
  either	
  written	
  or	
  electronic.	
  	
  We	
  believe	
  both	
  are	
  needed.	
  	
  Central	
  Asia,	
  as	
  in	
  likely	
  
the	
  entire	
  world,	
  still	
  retains	
  reliance	
  on	
  printed	
  materials.	
  	
  They	
  are	
  easy	
  to	
  produce,	
  always	
  handy,	
  do	
  
not	
  require	
  computers	
  or	
  PDAs,	
  etc.	
  	
  These	
  can,	
  however,	
  be	
  augmented	
  by	
  electronic	
  materials,	
  
particularly	
  for	
  teaching	
  purposes.	
  	
  
Electronic	
  materials	
  for	
  teaching	
  offer	
  advantages	
  and	
  may	
  be	
  successful	
  in	
  reaching	
  distant	
  audiences,	
  
be	
  economical,	
  and	
  allow	
  self-­‐study.	
  	
  They	
  also	
  have	
  disadvantages,	
  such	
  as	
  the	
  need	
  for	
  an	
  accessible	
  
computer	
  and	
  the	
  need	
  for	
  multiple	
  computers	
  if	
  they	
  replace	
  symposia	
  or	
  written	
  materials.	
  	
  	
  We	
  
propose	
  a	
  combination	
  of	
  electronic	
  materials	
  and	
  written	
  materials	
  for	
  teaching,	
  along	
  with	
  symposia	
  
for	
  teaching,	
  discussing,	
  answering	
  questions,	
  and	
  for	
  culture	
  change.	
  	
  Certification	
  of	
  successful	
  
completion	
  of	
  training	
  can	
  be	
  used.	
  
An	
  evaluation	
  of	
  our	
  program	
  is	
  needed.	
  	
  Two	
  types	
  of	
  evaluation	
  are	
  needed.	
  	
  First,	
  we	
  must	
  measure	
  
gain	
  in	
  knowledge,	
  e.g.,	
  pre-­‐test/post-­‐test	
  evaluation	
  of	
  the	
  individual.	
  	
  Second,	
  we	
  must	
  measure	
  
change	
  in	
  practice.	
  	
  	
  The	
  latter	
  will	
  require	
  a	
  more	
  difficult	
  evaluation,	
  e.g.,	
  practice/chart	
  audit,	
  on-­‐site	
  
evaluation.	
  	
  We	
  propose	
  doing	
  both.	
  
	
  
Outline	
  of	
  our	
  program:	
  	
  	
  
Phase	
  1:	
  Production	
  (till	
  February	
  20,	
  2013)*	
  
1. Produce	
  an	
  electronic	
  technical	
  document	
  according	
  ICATT	
  that	
  will	
  be	
  a	
  stand-­‐alone	
  training	
  
tool	
  concerning	
  appropriate	
  use	
  of,	
  insertion	
  of,	
  and	
  care	
  of	
  devices;	
  
2. Produce	
  a	
  written	
  version	
  of	
  the	
  same	
  document;	
  
 
	
  
	
  
	
  
	
  
	
  
	
  
	
  
	
  
	
  
Support to the Republic of Kazakhstan in Infectious Disease Prevention and
Control
is a project funded by the European Union.	
  
	
  
3. Produce	
  teaching	
  materials	
  for	
  use	
  the	
  electronic	
  document,	
  that	
  can	
  follow	
  the	
  guidance	
  (see	
  
below)	
  used	
  for	
  Integrated	
  Management	
  of	
  Childhood	
  Diseases	
  (IMCI);	
  
4. Pilot-­‐test	
  and	
  train	
  staff	
  in	
  pilot	
  health	
  care	
  facilities	
  in	
  use	
  of	
  ICATT	
  	
  
Phase	
  2:	
  Consolidation(till	
  May	
  1	
  2013,	
  end	
  of	
  GIZ/EUNIDA	
  project,	
  and	
  after)*	
  
5. Meet	
  with	
  health	
  care	
  institution	
  leaders	
  and	
  opinion	
  leaders	
  to	
  gain	
  their	
  support;	
  
6. In	
  pilot	
  institutions,	
  evaluate	
  practices	
  as	
  a	
  baseline;	
  
7. In	
  pilot	
  institutions,	
  hold	
  symposia	
  with	
  staff—either	
  doctors	
  alone	
  and	
  nurses	
  alone,	
  or	
  
combined,	
  as	
  appropriate—to	
  introduce	
  our	
  materials	
  and	
  begin	
  to	
  change	
  culture	
  and	
  
practices;	
  	
  	
  
8. Undetermined,	
  is	
  then	
  whether	
  to	
  train	
  entirely	
  in	
  symposia/small	
  groups,	
  or,	
  introduce	
  via	
  
symposia	
  the	
  subject	
  area	
  and	
  continue	
  training	
  using	
  electronic	
  materials.	
  	
  In	
  some	
  trial	
  
situations,	
  only	
  electronic	
  materials	
  might	
  be	
  used.	
  	
  	
  
9. Evaluate	
  knowledge	
  gained	
  and	
  if	
  one	
  approach	
  might	
  be	
  better	
  than	
  another;	
  
10. Evaluate	
  practice	
  change	
  at	
  selected	
  hospitals;	
  
11. Revise	
  technical	
  document	
  and	
  teaching	
  materials	
  and	
  finalize;	
  
12. Train	
  trainers,	
  to	
  “roll	
  out”	
  program	
  to	
  non-­‐pilot	
  institutions	
  and	
  scale	
  up	
  repeating	
  “best	
  
practices”	
  from	
  our	
  pilot	
  experience;	
  
13. Write	
  Prikaz;	
  
14. Institutionalize	
  program:	
  yearly	
  electronic	
  updates	
  of	
  contents	
  by	
  KNMU,	
  healthcare	
  workers	
  
yearly	
  (self/e-­‐)	
  tested	
  and	
  certificated	
  by	
  RSES/KNMU/(MOH?)	
  
	
  
George	
  Schmid,	
  CDC	
  CAR	
  
Jadranka	
  Mimica,	
  UNICEF	
  
Olga	
  de	
  Haan,	
  GIZ/EUNIDA	
  
*	
  UNICEF	
  finances	
  production	
  	
  in	
  Phase	
  1,	
  e.g.	
  the	
  preparation	
  and	
  production	
  of	
  the	
  ICATT-­‐tool,	
  to	
  be	
  distributed	
  on	
  
CDROM/flash	
  sticks.	
  	
  EUNIDA	
  project	
  does	
  not	
  enable	
  the	
  production/distribution	
  of	
  written	
  materials	
  in	
  large	
  numbers	
  
**	
  The	
  EUNIDA	
  project	
  expires	
  at	
  May	
  31	
  2013,	
  input	
  in	
  time,	
  human	
  and	
  financial	
  resources	
  till	
  expiry	
  can	
  be	
  only	
  
guaranteed	
  as	
  far	
  as	
  the	
  capacities	
  of	
  HR	
  and	
  the	
  project	
  budget	
  enable	
  to	
  execute	
  all	
  mentioned	
  steps.	
  In	
  February	
  2013	
  
parties	
  involved	
  will	
  agree	
  on	
  responsibilities	
  and	
  follow-­‐up	
  to	
  achieve	
  end	
  results	
  as	
  written	
  above.	
  	
  
	
  
	
  

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KAZThe Paperlogo

  • 1.                     Support to the Republic of Kazakhstan in Infectious Disease Prevention and Control is a project funded by the European Union.     Developing  a  Program  to  Prevent  Device-­‐associated  Infections     Background:    The  countries  of  Central  Asia,  as  those  of  much  of  the  former  Soviet  Union,  have  suffered   from  an  under-­‐recognized  incidence  of  health  care-­‐acquired  bloodborne  pathogens,  most  commonly   HIV  and  hepatitis  C.    These  have  long  been  recognized  and,  although  the  exact  magnitude  of  them  is   uncertain,  they  remain  despite  sporadic  efforts  to  end  the  practices  that  lead  to  them.    The  practices,   including  reuse  of  health  care  instruments  and  devices,  likely  persist  because  Central  Asia  is  “caught”   between  newest  technologies  and  not  sufficient  resources  or  knowledge  to  use  these  correctly.    The   existence  of  these  practices  clearly  places  patients  at  risk  of  life-­‐threatening  illness  and  health  care   personnel  and  institutions  in  morally  perilous  positions.    EUNIDA  and  GIZ  have  proposed  a  program  to   target  health  care-­‐associated  HIV  and  hepatitis  virus  infection.       The  practices  that  lead  to  these  infections  can  be  placed  into  two  categories:    1)  transfusion  practices;   and,  2)  device-­‐associated  infections  (DAIs).    The  first  is  a  specialized  area  and  other  programs  are   addressing  it;  EUNIDA/GIZ  propose  addressing  the  second  category.   DAIs  can  be  placed  into  two  categories:    1)  bloodborne  pathogens,  e.g.,  HIV,  hepatitis  B  and  C;  and,  2)   nonbloodborne  pathogens  associated  with  devices,  e.g.,  Staphylococcus  aureus.      The  frequency  of  the   second  category  of  infection  is  undetermined.    Although  EUNIDA  and  GIZ  focus  on  the  first  category,  we   propose  addressing  both  categories  of  infection.    This  makes  sense  because  if  devices  are  used   appropriately,  then  both  types  of  infections  will  be  prevented.    We  therefore  propose  a  program  to   address  the  proper  use  and  care  of  devices.   We  define  a  “device”  as  one  that  is  parenteral,  that  is  invasive,  and  which  might  lead  to  bloodborne   pathogen  transmission.    These  devices  might  be  called  intravascular  but  some  will  be  intramuscular,   e.g.,  injections.    They  have  the  common  feature  of  being  associated  with  blood.    While  some   instruments  can  conceivably  transmit  bloodborne  infections,  e.g.,  colonoscopy  instruments,  we  shall  not   address  such  “devices”  nor  the  cleaning  and  sterility  procedures  that  must  be  performed  to  reuse  them.     Rather,  we  shall  address  devices  that  are  associated  with  blood  and  are  typically  supplied  by   manufacturers  in  sterile  packaging  and  not  meant  for  reuse.    So,  we  include  peripheral  venous   catheters,  intraarterial  catheters,  subclavian  catheters,  etc.    The  types  of  devices  used  is  also  uncertain.     Subclavian  catheters  appear  to  be  commonly  used  and  are  often  implicated  in  recognized  outbreaks  of   HIV.    They  are,  thus,  a  focus  of  our  program.   Associated  paraphernalia,  e.g.,  multidose  vials  or  one  liter  IV  bags  of  fluid  (which  may  be  shared  among   patients,  particularly  in  pediatric  hospitals)  are  also  sources  of  infection  and  for  which  no  guidelines  on   use  exist.        Approach  to  our  program:      Devices  are  undoubtedly  overused,  although  there  are  no  guidelines  in   Kazakhstan  on  when  to  use  them.    A  recent  “injection  safety”  assessment  included  an  assessment  of  the   use  of  devices  and,  while  not  quantifying  how  commonly  they  are  used,  found  that  both  doctors  and  
  • 2.                     Support to the Republic of Kazakhstan in Infectious Disease Prevention and Control is a project funded by the European Union.     nurses  thought  that  they  were  used  only  in  appropriate  instances.    It  is  likely  that  Central  Asia  doctors   and  nurses  believe  that  devices  should  be  used  more  often  than  Western  counterparts.   We  believe  that,  despite  the  EUNIDA/GIZ  mandate  to  target  nurses,  any  program  to  prevention  DIAs   must  involve  doctors.    Doctors  hold  the  power  in  health  care  institutions  and,  unless  they  support   reforms,  any  program  targeting  only  nurses  will  achieve  minimal  results.    Thus,  we  propose  a  program   targeting  the  safe  use  of  devices  and  the  appropriate  use  of  devices.   An  intervention  must  target  not  only  knowledge  of  the  health  care  staff  but  also  culture  of  the   institutions  and  staff.    Achieving  change  of  culture  will  require  not  only  written  materials  but  verbal   interaction.    Targeted  would  be  not  only  decision-­‐makers,  largely  doctors,  but  opinion-­‐leaders,  largely   respected  physicians/leaders.      Symposia  as  well  as  individual  or  small  group  meetings  will  be   appropriate.    Ultimately,  clinical  practice  guidelines  (the  Prikaz)  will  be  needed  and  these  can  be  based  on  the   materials  we  shall  devise.       Our  materials  can  be  either  written  or  electronic.    We  believe  both  are  needed.    Central  Asia,  as  in  likely   the  entire  world,  still  retains  reliance  on  printed  materials.    They  are  easy  to  produce,  always  handy,  do   not  require  computers  or  PDAs,  etc.    These  can,  however,  be  augmented  by  electronic  materials,   particularly  for  teaching  purposes.     Electronic  materials  for  teaching  offer  advantages  and  may  be  successful  in  reaching  distant  audiences,   be  economical,  and  allow  self-­‐study.    They  also  have  disadvantages,  such  as  the  need  for  an  accessible   computer  and  the  need  for  multiple  computers  if  they  replace  symposia  or  written  materials.      We   propose  a  combination  of  electronic  materials  and  written  materials  for  teaching,  along  with  symposia   for  teaching,  discussing,  answering  questions,  and  for  culture  change.    Certification  of  successful   completion  of  training  can  be  used.   An  evaluation  of  our  program  is  needed.    Two  types  of  evaluation  are  needed.    First,  we  must  measure   gain  in  knowledge,  e.g.,  pre-­‐test/post-­‐test  evaluation  of  the  individual.    Second,  we  must  measure   change  in  practice.      The  latter  will  require  a  more  difficult  evaluation,  e.g.,  practice/chart  audit,  on-­‐site   evaluation.    We  propose  doing  both.     Outline  of  our  program:       Phase  1:  Production  (till  February  20,  2013)*   1. Produce  an  electronic  technical  document  according  ICATT  that  will  be  a  stand-­‐alone  training   tool  concerning  appropriate  use  of,  insertion  of,  and  care  of  devices;   2. Produce  a  written  version  of  the  same  document;  
  • 3.                     Support to the Republic of Kazakhstan in Infectious Disease Prevention and Control is a project funded by the European Union.     3. Produce  teaching  materials  for  use  the  electronic  document,  that  can  follow  the  guidance  (see   below)  used  for  Integrated  Management  of  Childhood  Diseases  (IMCI);   4. Pilot-­‐test  and  train  staff  in  pilot  health  care  facilities  in  use  of  ICATT     Phase  2:  Consolidation(till  May  1  2013,  end  of  GIZ/EUNIDA  project,  and  after)*   5. Meet  with  health  care  institution  leaders  and  opinion  leaders  to  gain  their  support;   6. In  pilot  institutions,  evaluate  practices  as  a  baseline;   7. In  pilot  institutions,  hold  symposia  with  staff—either  doctors  alone  and  nurses  alone,  or   combined,  as  appropriate—to  introduce  our  materials  and  begin  to  change  culture  and   practices;       8. Undetermined,  is  then  whether  to  train  entirely  in  symposia/small  groups,  or,  introduce  via   symposia  the  subject  area  and  continue  training  using  electronic  materials.    In  some  trial   situations,  only  electronic  materials  might  be  used.       9. Evaluate  knowledge  gained  and  if  one  approach  might  be  better  than  another;   10. Evaluate  practice  change  at  selected  hospitals;   11. Revise  technical  document  and  teaching  materials  and  finalize;   12. Train  trainers,  to  “roll  out”  program  to  non-­‐pilot  institutions  and  scale  up  repeating  “best   practices”  from  our  pilot  experience;   13. Write  Prikaz;   14. Institutionalize  program:  yearly  electronic  updates  of  contents  by  KNMU,  healthcare  workers   yearly  (self/e-­‐)  tested  and  certificated  by  RSES/KNMU/(MOH?)     George  Schmid,  CDC  CAR   Jadranka  Mimica,  UNICEF   Olga  de  Haan,  GIZ/EUNIDA   *  UNICEF  finances  production    in  Phase  1,  e.g.  the  preparation  and  production  of  the  ICATT-­‐tool,  to  be  distributed  on   CDROM/flash  sticks.    EUNIDA  project  does  not  enable  the  production/distribution  of  written  materials  in  large  numbers   **  The  EUNIDA  project  expires  at  May  31  2013,  input  in  time,  human  and  financial  resources  till  expiry  can  be  only   guaranteed  as  far  as  the  capacities  of  HR  and  the  project  budget  enable  to  execute  all  mentioned  steps.  In  February  2013   parties  involved  will  agree  on  responsibilities  and  follow-­‐up  to  achieve  end  results  as  written  above.