The IPBES global assessment highlights an unprecedented deterioration of nature, with 1 million species at risk of extinction and significant habitat loss projected by 2050. It emphasizes that the loss of biodiversity undermines the achievement of the Sustainable Development Goals and introduces the need for transformative change to address biodiversity loss and prevent future pandemics. Urgent actions—including ecosystem conservation, sustainable urban development, and transforming agriculture—are essential to mitigate these challenges.