Glucose secretionGlucose secretion

1. Glucagon is a 29 amino acid peptide hormone,
produced by alpha cells of islet of langerhan in
the pancreas. It raises concentration of glucose
and fatty acids in the bloodstream, and is
considered to be the main catabolic hormone of
the body.

2.  Glucagon secretion is stimulated by the
ingestion of protein, by low blood glucose
concentrations (hypoglycemia), and by
exercise. It is inhibited by the ingestion of
carbohydrates, an effect that may be mediated
by the resultant increase in blood glucose
concentrations and insulin secretion.

3.  Although secreted by the pancreas, glucagon directly
impacts the liver as it works to control blood sugar
levels. Specifically, glucagon prevents blood glucose
levels from dropping to a dangerous point by
stimulating the conversion of stored glycogen to
glucose in the liver. This glucose can be released into
the bloodstream, a process known as
glycogenolysis.Secondly, glucagon stops the liver from
consuming some glucose. This helps more glucose to
enter the bloodstream, rather than being consumed by
the liver, to keep levels stable.Finally, glucagon works
in a process known as gluconeogenesis, which is the
production of glucose in the amino acid and fatty acids
molecules.

4.  Glucagon: acts on liver, cardiac and skeletal
muscles, adipose tissue, and other tissues;
stimulates glycogenolysis (breakdown of
glycogen into glucose) in liver; stimulates
gluconeogenesis (conversion of non-
carbohydrates into glucose); stimulates liplysis
(breakdown of stored fat) in adipose tissues.

5.  Blood sugar regulation is the process by which
the levels of blood sugar, primarily glucose, are
maintained by the body within a narrow range.
This tight regulation is referred to as glucose
homeostasis.

6. Hyperglucagonemia is a state of excess glucagon
secretion. In healthy individuals, insulin has a
suppressive effect on alpha-cell function and
on glucagon secretion[7:21 PM, 6/1/2021]
Brother: on glucagon production. Although
rare, hyperglucagonemia can be caused by an
autonomous secretion of glucagon by a tumor
of pancreatic alpha cells (glucagonoma
syndrome). Most patients are middle-aged

7.  GLUT1 deficiency syndrome is caused by
mutations in the SLC2A1 gene. This gene
provides instructions for producing a protein
called the glucose transporter protein type 1
(GLUT1

8.  Hypoglycemia is a condition in which your
blood sugar (glucose) level is lower than
normal. Glucose is your body's main energy
source.