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An illustrative presentation on Urinalysis for detection of abnormal constituents for medical ,dental , pharmacology and biotechnology students to facilitate easy-learning.
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• INTRODUCTION • Diagnosis & identification - disease by careful investigation of patients signs, symptoms and history • Times when more information is required through the use of diagnostic tests. • Clinical and/or lab data must be used to distinguish between different diagnoses. • laboratory tests - important in assisting & management of the patient during treatment of disease besides diagnosis. 1. screen - disease in asymptomatic individual 2. to establish or exclude presence of diseases in symptomatic patients 3. assist the practitioner in the management of the patient. • CBC • Hemoglobin & Hematocrit • Hemoglobin : M: 13.8 to 17.2 gm/dL F: 12.1 to 15.1 gm/dL Hematocrit : (packed cell volume) • It is ratio of the volume of red cell to the volume of whole blood. M: 40.7 to 50.3 % F: 36.1 to 44.3 % • ERYTHROCYTE SEDIMENTATION RATE [ESR] • Normal range- male = 0 to 20mm/hr female = 0 to 10mm/hr • Non specific test • Eleveted in infections ,infarctions, trauma , or tumours. • The Reticulocyte Count • This important value is needed in the evaluation of any anemia. • Normal range 1-2% • Retic count goes up with – Hemolytic anemia – Retic goes down with – Nutritional deficiencies • _ Diseases of the bone marrow itself • Clinical importance • Hematocrit is valuable in evaluating polycythemia, anemia and blood loss. • RBC count provides a gross estimate of the bodys oxygen carrying capacity and used in red blood cell indices. • NEUTROPHIL • polymorphneuclear leukocytes (PMN,s) • Nucleus 3-5 lobes. • Diameter 10-14 µm • 50-70% WBC • Function: Phagocytosis of bacteria and cell debris • Numbers rise with all manner of stress, especially bacterial infections • Neutrophil disorders – Neutrophilia – an increase in neutrophils – Conditions associated with neutrophilia are: 1-Bacterial infections (most common cause) 2-Tissue destruction e.g. tissue infarctions, burns. 3- leukemoid reaction 4-Leukemia • NEUTROPENIA • Decrease in neutrophill count • Conditions associated ; 1. Certain infections- typhoid, malaria 2. Drugs , chemical and physical agent 3. Certain hematological diseases; aplastic anemia. • EOSINOPHIL • Bilobed nucleus • 1-5% of WBC • Diameter about 10-14 µm • Function: Involved in allergy, parasitic infections • Contains: Eosinophilic granules – Eosinophilia may be found in • Parasitic infections • Allergic conditions and hypersensitivity reaction • LYMPHOCYTES • No specific granules • 20-40% of WBC • Diameter 8-10 µm • T cells: cellular • (for viral infections) • B cells: humoral (antibody) • Natural Killer Cells • Lymphocytosis – may indicate _ Viral infection e.g. Infectious mononucleosis, CMV or pertussis. _ Bacterial infection e.g. TB • Lymphopenia – caused by • _Stress. • _Steroid therapy • _ Irradiation • Abnormal result of WBC • (Leukocytosis) may indicate: • _ Infectious diseases • _Inflammatory disease (such
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URINE EXAMINATION RENAL DISEASES.pptx
1.
DR.N.MANJULA
2.
3.
• M/C performed
lab tests.
4.
5.
6.
PHYSICAL EXAMINATION CHEMICAL EXAMINATION MICROSCOPIC
EXAMINATION
7.
VOLUME COLOR pH APPEARANCE ODOR SPECIFIC GRAVITY
8.
PROTEIN GLUCOSE KETONE BLOOD BILIRUBIN BILE SALTS RENAL DISEASE
9.
• Kidneys excrete
150mg/24hours. • Includes proteins from plasma and proteins derived from urinary tract. • Proteinuria refers to excretion of urine more than 150mg/24hours. • CAUSES: • 1.PRE RENAL • 2.RENAL • 3.POST RENAL
10.
PRE RENAL PROTEINURIA: •
INTRAVASCULAR HEMOLYSIS • MUSCLE INJURY • INFECTION RENAL PROTEINURIA: GLOMERULAR CAUSE: • GLOMERULONEPHRITIS, MINIMAL CHANGE DISEASE, DIABETES MELLITUS. TUBULAR CAUSE: • PYELONEPHRITIS, FANCONI SYNDROME. POST RENAL PROTEINURIA: • INFLAMMATION / NEOPLASM OF URINARY TRACT.
11.
12.
13.
14.
15.
EDEMA HEMATURI A HYPERTENSI ON NEPHRITI C
16.
EDEMA Proteinuria (> 3.5 g/24 hours) Hypoalbuminaem ia
(< 30 g/L) NEPHROTI C
17.
• AKA LIQUID
BIOPSY OF URINARY TRACT.
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