This is to help the young researchers to carry out their research in Pharmaceutical Chemistry, Medicinal Chemistry, Drug Design, Lead Optimization areas. I am providing the major important steps in the Synthesis of novel derivatives having some therapeutic potency.

1. Introduction to Research Protocol for
Pharmaceutical and Medicinal Chemistry Research
Department of Pharmaceutical Chemistry
Annamacharya College of Pharmacy
New Boyanapalli, Rajampet - 516126
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* *
By
M. Nagendra Babu

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IDENTIFICATION OF PROBLEM
???
Problem
Disease
Target
Toxicities
of Drugs
Drug
Resistance

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LITERATURE
Journals/Books/Articles/Scientific Magazines
Patents
Reports
Debates by Pharma. Industries during Conferences

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AIM & OBJECTIVES
Lead
Identification
and
Optimization
Synthesis of
Optimized
Derivatives
Characterization
of Synthesized
Derivatives
Biological
Screening
To Synthesize Novel
Derivatives of
Therapeutic Potential

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RESEARCH PROTOCOL
Selection of Lead
Optimization of Lead
Synthesis of Optimized Structural Analogs
Characterization of Synthesized Analogs
Biological Screening

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SELECTION OF LEAD
Lead
Pharmaco
phore
Pharmaco
phore
Pharmaco
phore
Pharmaco
phore
N
NH
O
NH2

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OPTIMIZATION OF LEAD

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SYNTHESIS OF OPTIMIZED STRUCTURAL ANALOGS

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CHARACTERIZATION OF SYNTHESIZED ANALOGS
IR
• Identification of functional groups
NMR
• Identification of number & nature of protons
• Identification of number of carbons
Mass
• Identification of molecular mass

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BIOLOGICAL SCREENING
In-vitro Assays
Toxicity Assays
In-vitro & in-vivo
Ex-vivo Assays In-vivo Assays
B i o l o g i c a l s c r e e n i n g M e t h o d s

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