2. Nutrigenomics is establishing the effect of
ingested nutrients and other food
components on gene expression.
It is fusion of nutrition and genomics.
It will also determine the individual
nutritional requirements based on the
genetic makeup of the person as well as the
association between diet and chronic
diseases
3. Substances contained in the food (micro-macro-
nutrients)can directly or indirectly affect the human
genome through changes in its structure and gene
expression
Under certain circumstances and in some individual
that diet can be an important risk factor for the
development of the number of diseases.
Some gene regulated by active substances in the diet
probably play a crucial role in the on set, incidence,
progression and severity of the disease.
4. The degree to which diet influences the
balance between health and disease may
depend on individuals genetic makeup.
Nutritional interventions is based on the
knowledge of individuals nutritional status
and needs as well as genotype(individualized
nutrition)and can be used for prevention,
mitigation or healing the chronic diseases.
5. DNA
Gene regulation ,SNP’s,trancriptional
control,histone interaction
RNA
Translational controlprocessing,stability,
transport of mRNA
Protein
Post-translational modifications Receptor
expression,Enzyme regulation,Singnal
transduction ,transport regulation
Metabolite
All cellular mediators
FOOD
Nutrients&
non-nutriens
Diet,nutrition
&Health
6. Direct interactions
Nutrients , sometimes after interacting with receptors ,
behave as transcription factors that can bind to DNA and a
cutely induce gene expression.
Epigenetic interactions
Nutrients can alter the structure of DNA so that gene
expression is chronically altered.
Gene variation
Common genetic variation such as single nucleotide
polymorphism(SNP)s can alter the expression or
functionality of gene.
7. Cardiovascular diseases
cardiovascular disease is a chronic disease that
is related group of abnormal condition such
as obesity hypertension and thrombosis.
ApolipoproteinA-1 HDL is produced
