In general, cell therapy includes tumor cell immunotherapy and stem cell therapy. There are two cell sources for cell therapy, one from the patient itself and the other from the allogeneic tissue. https://www.creative-bioarray.com/products/cytokines-growth-factors-17.htm

1. Creative Bioarray
The Complete Guide to Know
about Cell Therapy from The
Point of Standardization, Scale,
and Industrialization

2. What is cell therapy? The Defects of Cell Therapy
Difficulties in Cell Therapy Future development

3. PART
Creative Bioarray
What is cell therapy?
ONE

4. What is cell therapy?
Cell therapy refers to the transplantation or input of normal or bioengineered human cells into a
patient's body and newly-imported cells can replace damaged cells or involve a stronger
immune killing function, so as to achieve the purpose of treating diseases. Cell therapy has
shown higher application value in the treatment of cancer, hematological diseases,
cardiovascular diseases, diabetes, Alzheimer's disease etc. In general, cell therapy includes
tumor cell immunotherapy and stem cell therapy. There are two cell sources for cell therapy, one
from the patient itself and the other from the allogeneic tissue.
Brief Introduction

5. PART
Creative Bioarray
The Defects of Cell
Therapy
TWO

6. The Defects of Cell Therapy
The cell is the most basic unit that contributes to a living organism, however, it does not mean
that everyone shares the same cells. On the contrary, there is a huge difference in each
individual which can be compared to human-to-human differences, that is, two identical
people never exist. The huge difference between cells and cell preparations is the biggest
drawback of cell therapy. In this post, we will discuss several issues that need attention in the
current stage of cell therapy.

7. PART
Creative Bioarray
Difficulties in Cell Therapy
Three

8. Difficulties in the Standardization
Cancer cell immunotherapy cannot be
standardized from the stage of raw
material acquisition. The cell treatment
materiasl for each paitient are their own
blood leukocytes. The condition and
physical condition of each patient are
different, and the collected white blood
cell growth quantity and kill activity are
not uniform and cannot be standardized.
Taking stem cell therapy that using
umbilical cord mesenchymal stem
cells as an example, which raw
material is an umbilical cord, and
one umbilical cord-produced cell can
be utilized by many paitients. The
standardization path is more
advanced than the immunotherapy
of tumor cells, and the raw materials
can be standardized to some extent.

9. At present, the production mode of the cell therapy
industry maily depends on technicians. In the 10,000-
grade clean laboratory, the cells are operated in a
class 100 clean bench, cultured in a carbon dioxide
incubator, centrifuged in a centrifuge, observed
through an inverted microscope, and the drug
reagents are stored in a medicine refrigerator.
Difficulties in The Scale of Cell Therapy
Due to the small scale, the instruments used are
laboratory instruments and many of the reagents
used are scientific reagents, which will lead to the
issue of low efficiency but high cost.

10. There are two kinds of cell
sources for cell therapy, one
from the patients and the
other from the allogeneic
tissue.
If the advanced technology cannot
be mass-produced on a large scale,
it can only stay in the laboratory and
become the object of research for
scientists, never have achance to
become a drug into the majority of
patients.
Autologous or Allogeneic cells
For allogeneic cell therapy that using
allogeneic cells as raw materials, the
standardized properties of the scaled
products can be realized if large-scale
cultures are prepared, then scale and
standardization can promote each
other.

11. Brief Introduction on cytokine
Cytokines are a class of small molecule proteins with broad biological activity synthesized and secreted by
immune cells (such as monocytes, macrophages, T cells, B cells, NK cells, etc.) and certain non-immune
cells (endothelial cells, epidermal cells, fibroblasts, etc.) Immune responses are regulated by binding to the
respective receptors to regulate cell growth, differentiation and effects. Cytokines (CK) are low-molecular-
weight soluble proteins that are produced by various types of cells induced by immunogens, mitogens, or
other stimulants. They have the ability to regulate innate immunity [1] and adaptive immunity [2],
hematopoiesis, cell growth, and damage tissue repair and other functions.
Natural cytokine supernatants with more standardized and
standardized properties

12. Classification of Cytokines
. interleukins,
. interferons,
. t u m o r n e c r o s i s f a c t o r
superfamily,
. colony stimulating factors,
. chemokines,
. growth factors

13. PART
Creative Bioarray
Future Development
Four

14. In recent years, recombinant
gene cytokines have made
remarkable achievements in
clinical applications as a novel
biological response modifier. A
large part of the effects of stem
cell therapy and immune cell
therapy arises from the action
of cytokines secreted in the
body.
Future Development

15. Future Development
The stem cells and immune cells in the body
are introduced back into the body to secrete
a variety of natural structural cytokines.
Although the amount of these cytokines is
relatively small, they are synergistic and act
directly on the cytokine network in the body
because of their high natural structure activity,
lack of antigenicity but diversity. Because of
the standardization, standardization,
industrialization, and scale of natural
compound cytokines, it is more cost-effective
than cell therapy, allowing more patients in
need to enjoy cell-like therapeutic effects.

16. Email: contact@creative-bioarray.com
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