2. WHAT IS PROGERIA?
• Hutchinson-Gilford Progeria
Syndrome (HGPS)
– Rare, fatal genetic condition
– Accelerated aging in children
– Not sex linked or passed from parent
to offspring
– 1 in 1-8 million
Source: http://www.humandiseases.org/progeria-disease.html
3. SYMPTOMS
• Physical Characteristics: 18-12
months
– Growth failure
– Loss of body fat and hair
– Aged-looking, thin skin
– Stiffness of joints
– Hip dislocation
– Heart Disease Source: http://www.documentingreality.com/forum/f149/progeria-16225/
– Stroke
• Death by heart disease at an
4. RAPID AGING
• Heart Disease
– High blood pressure
– Strokes
– Angina
– Enlarged heart
– Heart failure
• Research provides keys in
treating heart disease
Source: http://www.all2need.com/understanding-heart-disease/
5. causes
• LMNA (Lamin A gene) mutation
Norm
– Produces Lamin A protein al
Nucleu
• Holds the nucleustogether s
• Defect makes the nucleus unstable
– Mutation leads to premature aging
Nucleus with
defect
Source: http://www.medicalnewstoday.com/articles/146746.php
6. diagnosis
• Clinical evaluation
– Appearance
– Medical Records
• Blood test
Source: http://www.medicalnewstoday.com/articles/146746.php
7. IS THERE A CURE?
• No cure
• Finding a cure
– Cell and tissue bank
– Medical & Research Database
• Medical recommendations
• Nutritional recommendations
– “The Progeria Handbook”
• Daily care recommendations
• Basic health facts
• Extensive treatment guidelines
8. Treatment
• No specific treatment
– Low-dose aspirin
– Other medications
– Physical and occupational therapy
– Extraction of primary teeth
• Investigational treatment
– Farnesyltransferase inhibitors (FTIs)
• Drugs that may correct cell defects
9. FOR MORE INFORMATION, GO TO THE
PROGERIA RESEARCH FOUNDATION
WEBSITE
PROGERIARESEARCH.OR
G
10. WORKS CITED
1. “Progeria.” Mayo Clinic. N.p., n.d. Web.
21 Feb. 2012.
<http://www.mayoclinic.com/health/
progeria/DS00936/DSECTION=treatme
nts-and-drugs>.
2. Progeria Research Foundation. N.p.,
n.d. Web. 21 Feb. 2012.
<http://www.progeriaresearch.org/p
rogeria_101.html>.
3. “What Is Progeria?” Medical News
Today. N.p., n.d. Web. 21 Feb. 2012.
Editor's Notes
Permanent teeth come in before baby teeth fall outFTIs were originally developed for treating cancer
