Progeria is the rare disease. So i want to grow a awareness among the people about this rare disease.

1. PROGERIA

2. HISTORY
It was also described independently in a academic
journal by Dr. Jonathan Hutchinson in 1886 and
Dr. Hastings Gilford in 1897.
The condition was later named Hutchinson-Gilford
progeria syndrome.
The word progeria comes from the Greek words
“pro” meaning “before” or “premature”, and
“geras” meaning “old age”.

3. WHAT IS PROGERIA?
Progeria is also known as Hutchinson-Gilford
Progeria Syndrome(HGPS)
It is a rare and very fatal genetic condition
Premature aging

4. PHATHOLOGY OF PROGERIA
Hutchinson-Gilford Progeria Syndrome is caused by
a mutation in gene called lamin A.
The defective lamin A protein makes the nucleus
unstable.

6. SIGNS & SYMPTOMS
 Limited growth
 Loss of hair
 early sings of skin aging, including thin skin
 Visible veins
 Loss of eyebrows and eyelashes
 Loss of body fat

7. DIAGNOSIS PROCESSES
Plotting measurements on a normal growth curve
chart.
Testing hearing and vision.
Measuring vital sings, including blood pressure.
Looking for visible sings and symptoms that are
typical of progeria.
Measuring height and weight.

8. TREATMENT
Low-dose Aspirin
Other medications
Physical and occupational therapy
Nutrition
Dental care

9. POTENTIAL FUTURE TREATMENT
Studying genes and the course of disease to understand
how it progresses. This may identify new treatments.
Studying way to prevent heart and blood vessel disease.
Performing human clinical trials using drugs known as
farnesyltransferase inhibitors (FTIs) such as lonafarnib.

10. PREVENTION
However, it has been recently discovered that FTIs, a
drug that has a possibility to help cure progeria,
might also be able to prevent the mishappen nuclei in
progeria cells.

11. MOVIE
Movie on progeria disease is “paa”.

12. CONCLUSION
Scientists are still looking for the to find the cure of this
abnormality syndrome.
Even though it has been seen for more than 100 years.
Progeria research foundation is now doing some DNA
mutation therapy to try to cure this disease.

13. REFERENCES
 1. Progeria Research Foundation. (2012). www.progeriaresearch.org.
 2. https://www.progeriaresearch.org/about-progeria.
 3. https://ghr.nlm.nih.gov/condition/hutchinson-gilford-progeria-syndrome#diagnosis.
 4. https://www.mayoclinic.org/diseases-conditions/progeria/symptoms-causes/syc-
20356038.
 5. https://emedicine.medscape.com/article/1117344-treatment.