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MORBUS STRANGULARIS POST KIDNEY TRANSPLANTATION:
CASE REPORT & REVIEW OF LITERATURE
Ahmed AKL1, Ahmed Donia1, Tarek Abbas1, Mohamed Dhab1, Moatsem Al Sayed1, Mohamed Hosny1, Mohamed Taher Fouad1, Salwa El Wasif1, Mohamed Abdel
Gawad2, Samir Sally1, Ashraf Foda1, Ehab Wafa1, Bedier Ali-El Dein1, Hussein Sheashaa1, Ayman Refaie1.
1 Urology & Nephrology Center, Mansoura University, Mansoura, Egypt.
2 Ear, Nose & Throat department, Mansoura University, Mansoura, Egypt
CASE
INTRODUCTION
FIGURES
CONCLUSION
Ludwig’s angina, otherwise known as angina Ludovici, is a serious, potentially life-threatening cellulitis, or connective tissue infection, of the floor of the mouth,
usually occurring in adults with concomitant dental infections and if left untreated, may obstruct the airways, necessitating tracheotomy, it is named after the
German physician, Wilhelm Friedrich von Ludwig who first described this condition in 1836. Other names include “angina Maligna”. Ludwig’s angina should not be
confused with angina pectoris, which is also otherwise commonly known as “angina”. The word “angina” comes from the Greek word ankhon, meaning “strangling”,
so in this case, Ludwig’s angina refers to the feeling of strangling, not the feeling of chest pain, though there may be chest pain in Ludwig’s angina if the infection
spreads into the retrosternal space. The life-threatening nature of this condition generally necessitates surgical management with involvement of critical care
physicians such as those found in an intensive care unit [1]. The microbiology of Ludwig’s angina is polymicrobial and includes many gram positive and negative
aerobic/anaerobic organisms, but commonly isolated are streptococcal spp., staphylococcus aureus, prevotella spp. And porphyromona spp. [2].
A 56-year-old man kidney transplant since 1996 with decompensated hepatitis C liver disease. Running on triple immunosuppression in the form of low dose
steroids, Tacrolimus and mycophenolate mofetil. He was admitted with history of dental abscess 3 days ago. Examination shows an acutely ill-appearing man with
evident facial edema in the area of the right jaw, no difficulty swallowing nor acute respiratory distress. Vital signs include an oral temperature of 38.7 C (101.7 F), a
heart rate of 90 bpm, and a respiratory rate of 18 breaths/min. Examination of the oral cavity reveals numerous carious teeth, dry oral mucosae, and tinge of
jaundice due to decompensated liver disease. Intravenous fluids and intravenous ceftriaxone were started immediately.
Three days later patient face has become swollen from his neck to the lower part of her ears, bilaterally. The patient sits upright with his mouth open and his tongue
protruding slightly. The floor of the mouth and anterior neck showed woody, tender edema with stiffness of the maxilla-mandibular joint and trismus.
Ultrasound of the neck showed evidence of supraglottic edema, a finding that is confirmed by a computed tomography (CT) scan confirms supraglottitis and soft-
tissue gas [Figure 1]. Leukocyte count was 36. 103/mm3, and anion gap measurement indicates metabolic acidosis.
After stabilization by administration of intravenous fluids and antibiotic agents, the patient was transferred to the operating room, where a drainage and cleaning of
the anterior neck and floor of the mouth space was done through 3 incisions: two submandibular & one submental. Blood clots and necrotic tissues were optimally
removed, tracheostomy was not indicated. The wounds were closed with drains [Figure 2.A]. Four days later, an additional drainage procedure was performed
because of an infected fluid collection, and complete dental extraction was done. Patient was discharged in a good condition and at basal graft function [Figure 2.B ].
MORBUS STRANGULARIS “Ludwig’s angina” is a dramatic, life-threatening, soft-tissue infection of the floor of the mouth and neck. If vigilant for its clinical
presentation and aware of its potential for rapid compromise of the patient’s airway, clinicians can intervene early in order to prevent its most dire consequences. It
is important to identify the correct diagnosis based on careful and complementary clinical examination, together with an effective drug coverage and early surgical
intervention to provide greater control of the patient’s health.
A] CT SKULL & NECK: SHOWING FINDING OF SUPRAGLOTTIC
OEDEMA AND SOFT TISSUE GASE FORMATION.
B] CT SKULL SHOWING SOFT TISSUE OEDEMA AND
GASE FORMATION.
FIGURE 2: DRAMATIC IMPROVEMENT OF THE PATIENT MONTHS AFTER EMERGENT NECK DRAINAGE & PROPER
ANTIBIOTICS MANAGEMENT.
A] IMMEDIATE AFTER DRAINAGE B] THREE MONTHS AFTER DRAINAGE
FIGURE 1: CT SKULL, NECK & UPPER CHEST
REFERENCES
UROLOGY&NEPHROLOGY CENTER
MANSOURA, EGYPT
1-Rowe, Ollapallil. “ Does surgical decompression in Ludwig’s angina decrease hospital length of stay?”. ANZ J Surg. Retrieved 2013-01-31.
2-Dhingra, PL: Dhingra, Shruti (2010) [1992]. Nasim, Shabina, ed. Diseases of Ear, Nose and Throat. Dhingra. Deeksha (5 ed). New Delhi: Elsevier. Pp. 277-278. ISBN 978-81-312-2364-2.

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Esnrt poster ludwing angina

  • 1. MORBUS STRANGULARIS POST KIDNEY TRANSPLANTATION: CASE REPORT & REVIEW OF LITERATURE Ahmed AKL1, Ahmed Donia1, Tarek Abbas1, Mohamed Dhab1, Moatsem Al Sayed1, Mohamed Hosny1, Mohamed Taher Fouad1, Salwa El Wasif1, Mohamed Abdel Gawad2, Samir Sally1, Ashraf Foda1, Ehab Wafa1, Bedier Ali-El Dein1, Hussein Sheashaa1, Ayman Refaie1. 1 Urology & Nephrology Center, Mansoura University, Mansoura, Egypt. 2 Ear, Nose & Throat department, Mansoura University, Mansoura, Egypt CASE INTRODUCTION FIGURES CONCLUSION Ludwig’s angina, otherwise known as angina Ludovici, is a serious, potentially life-threatening cellulitis, or connective tissue infection, of the floor of the mouth, usually occurring in adults with concomitant dental infections and if left untreated, may obstruct the airways, necessitating tracheotomy, it is named after the German physician, Wilhelm Friedrich von Ludwig who first described this condition in 1836. Other names include “angina Maligna”. Ludwig’s angina should not be confused with angina pectoris, which is also otherwise commonly known as “angina”. The word “angina” comes from the Greek word ankhon, meaning “strangling”, so in this case, Ludwig’s angina refers to the feeling of strangling, not the feeling of chest pain, though there may be chest pain in Ludwig’s angina if the infection spreads into the retrosternal space. The life-threatening nature of this condition generally necessitates surgical management with involvement of critical care physicians such as those found in an intensive care unit [1]. The microbiology of Ludwig’s angina is polymicrobial and includes many gram positive and negative aerobic/anaerobic organisms, but commonly isolated are streptococcal spp., staphylococcus aureus, prevotella spp. And porphyromona spp. [2]. A 56-year-old man kidney transplant since 1996 with decompensated hepatitis C liver disease. Running on triple immunosuppression in the form of low dose steroids, Tacrolimus and mycophenolate mofetil. He was admitted with history of dental abscess 3 days ago. Examination shows an acutely ill-appearing man with evident facial edema in the area of the right jaw, no difficulty swallowing nor acute respiratory distress. Vital signs include an oral temperature of 38.7 C (101.7 F), a heart rate of 90 bpm, and a respiratory rate of 18 breaths/min. Examination of the oral cavity reveals numerous carious teeth, dry oral mucosae, and tinge of jaundice due to decompensated liver disease. Intravenous fluids and intravenous ceftriaxone were started immediately. Three days later patient face has become swollen from his neck to the lower part of her ears, bilaterally. The patient sits upright with his mouth open and his tongue protruding slightly. The floor of the mouth and anterior neck showed woody, tender edema with stiffness of the maxilla-mandibular joint and trismus. Ultrasound of the neck showed evidence of supraglottic edema, a finding that is confirmed by a computed tomography (CT) scan confirms supraglottitis and soft- tissue gas [Figure 1]. Leukocyte count was 36. 103/mm3, and anion gap measurement indicates metabolic acidosis. After stabilization by administration of intravenous fluids and antibiotic agents, the patient was transferred to the operating room, where a drainage and cleaning of the anterior neck and floor of the mouth space was done through 3 incisions: two submandibular & one submental. Blood clots and necrotic tissues were optimally removed, tracheostomy was not indicated. The wounds were closed with drains [Figure 2.A]. Four days later, an additional drainage procedure was performed because of an infected fluid collection, and complete dental extraction was done. Patient was discharged in a good condition and at basal graft function [Figure 2.B ]. MORBUS STRANGULARIS “Ludwig’s angina” is a dramatic, life-threatening, soft-tissue infection of the floor of the mouth and neck. If vigilant for its clinical presentation and aware of its potential for rapid compromise of the patient’s airway, clinicians can intervene early in order to prevent its most dire consequences. It is important to identify the correct diagnosis based on careful and complementary clinical examination, together with an effective drug coverage and early surgical intervention to provide greater control of the patient’s health. A] CT SKULL & NECK: SHOWING FINDING OF SUPRAGLOTTIC OEDEMA AND SOFT TISSUE GASE FORMATION. B] CT SKULL SHOWING SOFT TISSUE OEDEMA AND GASE FORMATION. FIGURE 2: DRAMATIC IMPROVEMENT OF THE PATIENT MONTHS AFTER EMERGENT NECK DRAINAGE & PROPER ANTIBIOTICS MANAGEMENT. A] IMMEDIATE AFTER DRAINAGE B] THREE MONTHS AFTER DRAINAGE FIGURE 1: CT SKULL, NECK & UPPER CHEST REFERENCES UROLOGY&NEPHROLOGY CENTER MANSOURA, EGYPT 1-Rowe, Ollapallil. “ Does surgical decompression in Ludwig’s angina decrease hospital length of stay?”. ANZ J Surg. Retrieved 2013-01-31. 2-Dhingra, PL: Dhingra, Shruti (2010) [1992]. Nasim, Shabina, ed. Diseases of Ear, Nose and Throat. Dhingra. Deeksha (5 ed). New Delhi: Elsevier. Pp. 277-278. ISBN 978-81-312-2364-2.