it was our presentation on pharmaceutical tour

1. A
Presentation on
Pharmaceutical Chemistry Sessional & Field Visit
at
Kemiko Pharmaceuticals Ltd.
Presented By
Md. Mahamudul Hasan Rumon
Student ID:151827
4th year ,1st term
Chemistry Discipline
Khulna University,
Khulna

2. Company Profile
 Objective of The Tour
Drug & Medicine
Types of Medicine
Ointments & It Classification
Ointment Bases
Preparation of Ointment
Quality Control Test
Contents
01

3. Year of establishment : 1988
Location : Tikapara, Ghoramara, Rajshahi.
Sectors of the company : Production, Quality control, Quality assurance,
Research & Development and Marketing & Sales department
Total employee: 1900 skilled & qualified professionals.
Operating & marketing: More than 26 years.
Medicine
I. Herbal products
II. Animals medicine
III. Nutrition products
Kemiko Pharmaceuticals Limited 02

4.  To gather practical knowledge of Pharmaceutical product production.
 To see the raw materials they used in pharmaceutical product production.
 To acquire practical knowledge about the technical information in Pharmaceutical
product production.
 To acquire knowledge about testing process of making good quality
Pharmaceutical product.
 To know about the mechanical process of Pharmaceutical product production.
Objective of The Tour
03

5.  A substance that has a physiological effect when ingested or otherwise
introduced into the body.
Medicine is the dosage form of the drug. Drug is the active ingredient
of the medicine. Medicine= Drug + excipient Gels Solutions Ointments
Oils Creams Foams Sprays
What Is Drug?
What Is Medicine?
04

6. Solid Medicine
Semi Solid Medicine &
Liquid Medicine
Types Of Medicine 05

7. Tablet:-Tablets are solid unit dosage form of medicaments.
Capsule:- Capsules are solid unit dosage form of medicaments in which drugs
is enclosed by tasteless & soft container.
Solid Medicine 06

8. Ointment:- Ointment is semisolid preparations meant for external use on the skin or
mucous membrane.
Parenteral Product:- Parenteral products are sterile solutions and suspensions for
using through the layer of skin or mucous membrane.
Semi Solid Medicine
Liquid Medicine
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9. Ointments are soft semisolid preparation meant for external application to
the skin or mucous membrane .They usually contain medicament, which is
either dissolved or suspended in the base.
Characteristics of an Ideal Ointment:
It should be chemically and physically stable.
It should be smooth and free from grittriness .
It should melt or soften at body temperature and be easily applied.
The base should be non-irritating.
Ointments
08

10. Ointment May Be Classified As Follows:
According to their therapeutic properties based on penetration
According to their therapeutic uses
According To Their Therapeutic Properties Based On Penetration
Epidemic
Endodermic
Diathermic
Classification Of Ointment
09

11. AccordingToTheirTherapeutic Uses
• Antibiotic
• Antifungal Ointment
• Anti-inflammatory
• Dandruff treatment Ointment
• Emollient
• Protectant Ointment
10

12. The ointment base is that substance or part of an ointment preparation which serves
as carrier or vehicle for the medicament
The ointment bases are classified as follows:
• Oleaginous bases
• Absorption bases
• Emulsion base
• Water soluble base
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Ointment Bases:

13. Mechanical Incorporation:
A. Trituration method
B. Emulsification method
C. Mixing method
Fusion Method
Preparation Of Ointment
12

14. Trituration Method
Size reduction
Mixing with base
Trituration
Mixing base to produce final weight
Homogenization
Filling
Packing and sealing Store final product
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15. Emulsification Method
14

16. Fusion Method
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17. Additives And Storage Additives:
•Preservative
•Antioxidants.
•Chelating agents.
•Perfumes.
16

18. Advantages:
 They are relatively heat
stable.
 They are compatible with
majority of medicaments.
 These bases may be used in
their anhydrous from or in
emulsified form.
 They can absorb a large
quantity of water or aqueous
substances.
Disadvantages:
 Sometimes it causes
burn on skin because of
excess use.
 Some ointments contain
unstable substances
which are difficult to
standardize
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19. • Quality Control Test which is defined that
the set of activities for ensuring the quality
of the product that’s depends upon the
customer requirements.
• Quality Control Test which is to identify &
correct defects in the finished products
.
Quality Control Test
18

20. Quality Control (QC)
Ensure that products are pure, safe & effective.
Methods and procedure are developed.
Importance for customer satisfaction.
Provide confidence to internal management.
Improve the quality of product
19

21. 1. Dissolution test
2. Disintegration test
3. Hardness test
4. pH test
5. HPLC Test
6. Hardness Test
Tests performed in Quality Control 20

22.  Method to measure the rate of
drug release after a particular
time.
 Use acidic medium for stomach
& basic medium for intestine.
 Expressed as % of drug
dissolved in time limit.
Dissolution Test Disintegration Test
 Process of breaking down the
tablet or capsule into smaller
particles or granules.
 Determines the time of
disintegration.
 For stomach disintegration time
is maximum fifteen minutes.
Fig : Disintegration Tester
21

23. Magnetic Stirrer Hardness Test
Determine hardness and breaking point
 Carried out under conditions of storage,
transportation & handling
Depends on weight, nature and quantity of
excipients as well as applied pressure
•Dissolve the sample very fast
• Produce heat if requires
Figure : Magnetic stirrer
22

24. Gas Chromatography (GC): pH Meter
 It is used for determine the
pH
 Represents the acidity or
alkalinity of an aqueous
solution.
Fig: pH Meter
 Use for separating and analysing compounds
 It may help in identifying a compound
 Testing the purity of a particular substance
Fig.: GC
machine
23

25. To ensure about-
• purity of raw materials
• exact hardness & friability of tablets
• conductivity, viscosity, color, thickness, shape, size etc
• sterility of parenteral products prior to patient administration
Importance of Qc
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26. Reference
 Google
 Wikipedia
 Slide share
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