2. • Mesotherapy was invented by the Frenchman, Dr. Michael Pistor in
1958 mainly as a pain relieving technique.
• Dr. Lionel Bissoon introduced the technique in America.
• Its cosmetic application has gained attention recently, particularly for
removal of fat and cellulite.
3. WHAT IS MESOTHERAPY?
• Mesotherapy is a technique which involves microinjections of
conventional homeopathic medications or vitamins into the
mesoderm i.e, the middle layer of the skin.
• To promote healing or corrective treatment to a specific area of the
body.
5. MESONEEDLES
CLASSICAL INJECTION METHODS:
• Needles – 27G, 30G, 32G
• Syringes:
a. Slip tip
b. Luer lock – 5ml, 10ml, 20ml
c. Linear multiple injector
d. Circular multiple injector
e. Multi injector plates – 3,5&7 connectors
6. MESOGUN:
BENEFITS:
• Faster injections
• Precise dose delivery
• Consistent depth of penetration
• More comfort for patient and physician
• Has different modes – continuous, dosimetric, nappage and
mesoperfusion mode.
7.
8. SKIN AND SCALP ROLLERS:
• Available in 48 and 96 needle configuration.
• Four needles in each row with a gap of 5mm in between.
• Stimulates deeper layers of skin.
• Used in treatment of – acne, stretch marks, alopecia.
9.
10. TECHNIQUES OF INJECTION:
Mesotherapy involves injecting microquantities of medicine in right
place using one of the following technique,
• Intra epidermal.
• Papular.
• Nappage.
• Point by Point.
11. INTRA EPIDERMAL:
• Depth of injection – 1mm.
• Involves placing small quantities of medicine within the epidermis.
• Simple, painless, no bleeding.
• Ideal for facial rejuvenation.
• Used in patients with low pain threshold.
12. PAPULAR TECHNIQUE:
• Depth of injection – 2mm.
• Injecting medicine at the dermoepidermal junction.
• It is the technique used in mesobotox.
• Ideal to treat wrinkles and alopecia.
13. NAPPAGE:
• French word – covering.
• Injections given at depth of 2-4mm at an angle of 30-60 degree.
• Used mainly on scalp.
• Used to treat cellulite.
14. POINT BY POINT:
• Precise single injection into the deep dermis.
• Injectinos given at a depth of 4mm.
• Used mainly for pain reduction.
15. INDICATIONS:
• Cellulite.
• Local fat deposits – Xanthelasma, lipoma.
• Alopecia.
• Rejuvenation – wrinkles, skin tightening.
• Hyperpigmentation and melasma.
• Body contouring.
• Mesobotox.
19. 7. CRP 1000 – has cytokines (for cellular stimulation) and copper
peptide.
8. Vitamins:
• Vitamin C – antioxidant, increase collagen and elastin
production. Used in treatment of hyperpigmentation and
Melasma.
• Vitamin A – used in antiaging treatment (improves fine lines)
• Biotin – to treat alopecia.
20. CONTRAINDICATIONS:
• Age < 18 years.
• BMI > 30.
• Pregnancy and lactation.
• Insulin dependent diabetes.
• History of strokes/recent cancer.
• Severe cardiac and renal disease.
• Thromboembolic phenomenon.
• On medications – heparin, warfarin, aspirin.
• Hypersensitivity to the substance used.
21. GENERAL RECOMMENDATIONS:
• Should be applied by skilled doctors.
• To be integrated with standard treatments according to the needs of
the individual patient.
• Collect all clinical data in the patients medical record.
• Before applying mesotherapy, a diagnosis must be made.
22. • Doctors should report the pros and cons of this technique and allow
the patient to make a valid decision.
• A single drug is recommended in the syringe.
• Avoid contamination to avoid risk of infection.
• Use drugs according to authorized indications.
23. METHODS TO IMPROVE PATIENT SATISFICTION:
• Information about development of itching, bruising, soreness,
burning sensation, swelling at site are normal and shows that drug is
working.
• Procedure should be briefly explained to patient.
• Local application of ice packs – decrease swelling.
24. • Counselling regarding results of procedure prior so that patient will
not expect complete cure.
• Use of local anaesthesia – makes procedure more comfortable.
• Loose clothing after procedure.
• Massaging the site – to reduce formation of nodule.
32. NEWER TECHNIQUES:
1. MESOPERFUSION:
• Same volume injected over 10 mins instead of 30 seconds as in a
normal session.
2. NO NEEDLE MESOTHERAPY:
a. Cellulite
b. Skin rejuvenation
c. Hyperpigmentation of photoaging
d. Reduction of wrinkles and pores
e. Skin lifting and tightening
33. NO NEEDLE MESOTHERAPY:
• STEP 1: ELECTROPORATION – electric waves at the target size to
create electro pores of about 40-250 microns. Substance pass
through pores by electro repulsion.
• STEP 2: ACTIVE CURRENT – Improves vascularity and amount of
substance infused.
• STEP 3: HYDROPHORESIS – Penetration of water soluble substances.
• STEP 4: CRYOPHORESIS – Cold temperature locks substance inside the
skin.
34. ADVANTAGES OF NNM:
• Completely painless
• No bruising, erythema, swelling
• Materials penetrate to deeper levels
• Immediate/rapid response
• Cost effective
35. CONCLUSION:
• Mesotherapy gained popularity due to its non invasive, painless
nature.
• Mode of action of many products used in mesotherapy is either
doubtful or unknown.
• No clear cut guidelines on the dosage and efficacy of the products.
• Insufficient data evaluating the safety of technique and medicines.
• Therefore, mesotherapy should be used with caution.
36. REFERENCES:
• Vedamurthy M. Mesotherapy. Indian J Dermatol Venereol Leprol
2007;73:60-62
• Konda D, Thappa DM. Mesotherapy: What is new?. Indian J Dermatol
Venereol Leprol 2013;79:127-134
• Efficacy of mesotherapy in facial rejuvenation: a histological and
immunohistochemical evaluation by Moetaz El-Domyati MD et al.,
• Intradermal Therapy (mesotherapy) in Dermatology
