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CARVEDILOL AKA COREG
Non-selective beta-blocker with alpha-blocking activity
No intrinsic sympathomimetic activity
Decrease HR, vasodilation, increased stroke volume index,
reduction of cardiac output, decreased renal vascular
resistance
Immediate release tablet: 3.125 mg to 25-50 mg BID
Extended release capsule: 10 mg to 80 mg daily
Generic available
Dose range
No dose adjustment necessary
Contraindicated in severe liver impairment
With food, risk of orthostatic hypotension is low
Decompensated CHF/ cardio shock
Bronchial asthma
2nd or 3rd degree AV block, SSS, severe
bradycardia
Bradyarrhythmia
Bronchospasm
Fatigue, sleep disorder
Hypoglycemia masking
Hypotension, orthostasis
Vasospastic angina
Myasthenia Gravis
Peripheral vascular disease
DM-risk of hypoglycemia
Pheochromocytoma, untreated
Amiodarone- worsen bradycardia
Insulins/ Sulfonylurea- worsen hypoglycemia
Levodopa-Carbidopa- Worsen hypotension
Avoid use
Peak BP lowering effect in 1-2 hours
Half life: 7 to 10 hrs
MOA
Indications
Dosage
Renal Dose
Hepatic dose
Food
Adverse effects
Contraindications
Be cautious
DDI
Pregnancy/ Breastfeeding
PK/PD
What you must know?
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