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FREEZE DRYER
KASHISH WILSON
MM COLLEGE OF PHARMACY, MM(DU) MULLANA AMBALA
PRINCIPLE...
• Freeze drying or lyophilisation is a drying process used to
convert solutions or suspensions of labile materials into solids
of sufficient stability for distribution and storage. The
fundamental principle in freeze-drying is sublimation, the shift
from a solid directly into a gas. Just like evaporation,
sublimation occurs when a molecule gains enough energy to
break free from the molecules around it. Drying is achieved by
subjecting the materials to temperature and pressures below
the triple point
CONSTRUCTION..
CONTINUE...
• Drying chamber in which trays are loaded.
• Heat supply in radiation source, heating coils.
• Vapour condensing or adsorption system
• Vacuum pump or stream ejector or both.
CONTINUE...
WORKING

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Freeze dryer.pptx

  • 1. FREEZE DRYER KASHISH WILSON MM COLLEGE OF PHARMACY, MM(DU) MULLANA AMBALA
  • 2. PRINCIPLE... • Freeze drying or lyophilisation is a drying process used to convert solutions or suspensions of labile materials into solids of sufficient stability for distribution and storage. The fundamental principle in freeze-drying is sublimation, the shift from a solid directly into a gas. Just like evaporation, sublimation occurs when a molecule gains enough energy to break free from the molecules around it. Drying is achieved by subjecting the materials to temperature and pressures below the triple point
  • 4. CONTINUE... • Drying chamber in which trays are loaded. • Heat supply in radiation source, heating coils. • Vapour condensing or adsorption system • Vacuum pump or stream ejector or both.
  • 8. ADVANTAGES.... • It is suitable for drying heat sensitive products • Freeze dried products is porous and easy to dehydrated and instantly dissolved. • Drying takes place at very low temperature, so that enzyme action is inhibited and chemical decomposition, particularly hydrolysis, is minimized. • Denaturation of protein does not occur. • Loss of volatile material is less. • Sterility can be maintained
  • 9. DISADVANTAGES... • The process is very slow. • Expensive process. • It is not a general method of drying, but it is limited to certain type of valuable products that cannot be dried by any other means. • The period of drying is high. • The product is prone to oxidation, due to the high porosity and large surface area. • Therefore, the product must be vacuum packed or with an inert gas or in container
  • 10. • It is used in production of injection, solutions, and suspension. • It is also used for production of blood plasma and its fractionated products, bacterial and viral cultures, antibiotics and plant extracts, steroids, vitamins and enzymes. • Food product like mushroom, meat products can be dried by this method. • Coffee and tea concentrates and citrus fruit juices are also dried by this method. • Pharmaceutical companies often use freeze-drying to increase the shelf life of • products, such as vaccines and other injectable. PHARMACEUTICAL USES