Palmonary mechanism, palmonary drug Delivery System

1. Pulmonary Drug Delivery
System
Kamal Uddin Rayhan
Present by
North South University
Batch 151
Part-01

2. Pulmonary Drug Delivery
Delivery drug to the respiratory system is performed for
diagnostic and treatment of local disorder.
Upper airways -nasal cavity, pharynx and larynx
Lower airways -trachea, primary bronchi and bronchial tree.
Its readily absorption site and gain systemic absorption. Old
therapy that have first pass metabolism.

3. Anatomy of Respiratory Tract
Two region respiratory
tract-
• The conducting system
• Respiratory region
The lungs are divided
into lobes; The left lung is
composed of the upper lobe,
the lower lobe and
the lingual (a small remnant
next to the apex of the
heart), the right lung is
composed of the upper,
the middle and
the lower lobes

4. Anatomy of Respiratory Tract

6. Cell of Lung region

7. Factors effecting particle deposition in air
There are two factors-
1.Physiological Factors.
2.Pharmaceutical Factors.
 Lung morphology.
 Oral vs Nasal breathing.
 Inspiratory flow rate(IFR)
 Co-ordination of aerosol generation with inspiration.
 Tidal Volume.
 Breath Holding.
01) Physiological Factor-

8.  Shape.
 Density.
 Size of particles.
 Physical Stability.
02) Pharmaceutical Factors-
Factors effecting particle deposition in air
Mechanism of Drug Absorption
o Diffusion
o Absorption
o Phagocytosis

9. Mechanism of Pulmonary Drug absorption-

10. Generic Names of Drugs for Treatment of Respiratory
Diseases
1. Ambroxol
2. Aminophyllin
3. Amoxicillin
4. Calfactant etc