FULL ENJOY Call Girls In Majnu Ka Tilla, Delhi Contact Us 8377877756
Eb 2014 mm s consistent outcomes & iacuc presentation, final
1. MouseMonitor™ S
Surgical Monitoring
An integrated approach can help
your lab achieve consistent
outcomes, increase survival rates &
satisfy your IACUC
Product Workshop, Experimental Biology 20141
Presenter: Graham Sattler
Director of Product Development
Indus Instruments
2. MouseMonitor™ S
1) Surgical Monitoring
2) Integrated Physiologic Monitoring
3) MouseMonitor S Capabilities
4) Focus on Ease of Use
Overview
Product Workshop, Experimental Biology 20142
3. MouseMonitor™ S
Section 1) Surgical Monitoring
1) Surgical Monitoring
• Why Surgical Monitoring?
• Sketch of a Surgery
• IACUC Surgical Requirements
• Surgical Monitoring & Me
• Repeatability is Key
2) Integrated Physiologic Monitoring
3) MouseMonitor S Capabilities
4) Focus on Ease of Use
Product Workshop, Experimental Biology 20143
4. MouseMonitor™ S
How does it add value to my research?
Why Surgical Monitoring?
• Increase Survival Rates
• Increase Surgical Consistency
• Reduce Study Variability
• Satisfy IACUC Requirements
Product Workshop, Experimental Biology 20144
5. MouseMonitor™ S
Goal: Achieve a Specific Outcome
Sketch of a Surgery
• Induce Anesthesia
• Stabilize & Maintain Anesthesia
• Prepare Subject & Surgical Site
• Perform Surgical Procedure
• Recovery from Anesthesia
Product Workshop, Experimental Biology 20145
6. MouseMonitor™ S
Research Protocol Requirements Increasing
IACUC Surgical Requirements
• More Monitoring
• Non-Invasive Methods
• Better Heating
• More Documentation
Product Workshop, Experimental Biology 20146
7. MouseMonitor™ S
Researchers Have Many Responsibilities
Surgical Monitoring & Me
• Researcher
• Anesthesiologist
• Surgeon
• Quality Control Officer
• IACUC Compliance Officer
Monitoring Helps You at Every Step
Product Workshop, Experimental Biology 20147
8. MouseMonitor™ S
Surgical Monitoring Reduces Variability
Repeatability is Key
• Provide a Stable Preparation
• Spot Potential Problems Earlier
• Improve Survival Rates
Doesn’t this already exist
In the clinical space?
Product Workshop, Experimental Biology 20148
9. MouseMonitor™ S
Section 2) Integrated Physiologic Monitoring
1) Surgical Monitoring
2) Integrated Physiologic Monitoring
• Integrated Physiologic Monitoring?
• Brief History of Physiologic Monitors
• Clinical Monitoring Benefits
• What The Guide Says
• A Preclinical First
• Researcher Observations
3) MouseMonitor S Capabilities
4) Focus on Ease of Use
Product Workshop, Experimental Biology 20149
10. MouseMonitor™ S
What is it?
Integrated Physiologic Monitoring?
• Compact Presentation of Vital Signs
• Easy to Use Information
• Actionable Information
Product Workshop, Experimental Biology 201410
11. MouseMonitor™ S
You’ve Come a Long Way Baby
Brief History of Physiologic Monitors
• Timeline
• Decade Highlights
Product Workshop, Experimental Biology 201411
13. MouseMonitor™ S
Preclinical Recommendations Mirror Clinical
What The Guide Says
• NRC’s Guide for the Care and Use of Laboratory Animals
• Adopted by all Laboratory Animal Care Organizations
• Driving Increased IACUC Requirements
Product Workshop, Experimental Biology 201413
14. MouseMonitor™ S
Integrated Physiologic Monitoring with the MouseMonitor S
A Preclinical First
• Harness Clinical Advancements
• Reduce Mortality
• Improve Surgical Consistency
• Identify Problems Faster
• Research Focused Features
Product Workshop, Experimental Biology 201414
15. MouseMonitor™ S
Section 3) MouseMonitor S Capabilities
1) Surgical Monitoring
2) Integrated Physiologic Monitoring
3) MouseMonitor S Capabilities
• Non-Invasive Monitoring
• Responsive Heating
• Rigid Surgical Platform
• Research Quality Data
• Easy Study & IACUC Documentation
4) Focus on Ease of Use
Product Workshop, Experimental Biology 201415
17. MouseMonitor™ S
An Intelligent Heating Solution
Responsive Heating
• Zone-Based Electronic Heating
• Reaches Temperature 10x Faster
• Animal Safety is our Priority
Product Workshop, Experimental Biology 201417
0
5
10
15
20
25
MouseMonitor S Competitor's
Blanket
Minutes to Reach 39°C Set Temperature
18. MouseMonitor™ S
Designed for Rodent Surgery
Rigid Surgical Platform
• Rigid, Stable Work Surface
• Easily Cleanable & Sterilizable
• Enough Space to Rest Hands
Product Workshop, Experimental Biology 201418
19. MouseMonitor™ S
Data – it’s what research is all about
Research Quality Data
• High Resolution Signals
• Low Noise Electronics Design
• Non-interfering Modalities
• Full Resolution Analog Output
Product Workshop, Experimental Biology 201419
20. MouseMonitor™ S
Easily Tell your Research Story
Easy Study & IACUC Documentation
• Screenshots
• Recordings & Playback
Product Workshop, Experimental Biology 201420
25. MouseMonitor™ S
Section 4) Focus on Ease of Use
1) Surgical Monitoring
2) Integrated Physiologic Monitoring
3) MouseMonitor S Capabilities
4) Focus on Ease of Use
• Designed for Daily Stress-Free Use
• At-A-Glance Monitoring
• A Powerful Research Tool
• Flexibility & Value
Product Workshop, Experimental Biology 201425
26. MouseMonitor™ S
The Day is Already Short Enough
Designed for Daily Stress-Free Use
• Quick Setup
• Touch User Interface
• Powerful Presets
Product Workshop, Experimental Biology 201426
27. MouseMonitor™ S
Capture and Publish Quality Data
A Powerful Research Tool
• Capture Valuable Data
• Spend Less Time on
IACUC Compliance
Product Workshop, Experimental Biology 201427
28. MouseMonitor™ S
Increased Surgical Quality & Survival Rate
Researcher Observations
Product Workshop, Experimental Biology 201428
The MouseMonitor S is a complete and
effective tool to view physiological
parameters and they have proven
extremely effective. Our survival rate
has gone up, and the quality of our
surgeries has also improved.
–
Max Z.
What MouseMonitor S Customers are Saying
29. MouseMonitor™ S
Great Surgical Monitoring Solution
Researcher Observations
Product Workshop, Experimental Biology 201429
The MouseMonitor S has been a great
addition to the Mouse Phenotyping
Core, we use it for monitoring the mice
and maintaining body temperature
during various surgical procedures. It
has proven to be a very effective and
cost-efficient alternative to telemetry
but it still provides excellent ECG signals
from all three leads.
What MouseMonitor S Customers are Saying
30. MouseMonitor™ S
Easy to Use & Quality ECG
Researcher Observations
Product Workshop, Experimental Biology 201430
We are very impressed by the ease of
use and the quality of the ECG signals
and R trigger.
– Mathieu P., Ph.D.
What MouseMonitor S Customers are Saying
31. MouseMonitor™ S
A Wide Range of Capabilities
Flexibility & Value
• Many Applications
• Grows with Your Lab
• Great Value
Product Workshop, Experimental Biology 201431
32. MouseMonitor™ S
Supports All Phases of Your Research
Conclusion
• Integrated Physiologic Monitor
• Responsive Heater
• Rigid Surgical Platform
• Research Quality Data
• Easy Documentation
Product Workshop, Experimental Biology 201432
34. MouseMonitor™ S
Contact Info:
Graham Sattler
Director of Product Development
gsattler@indusinstruments.com
Phone: (281) 286-1130
Company Website:
www.mousemonitor.com/eb
with Webinars & More Product Info
Questions & Contact
Product Workshop, Experimental Biology 201434
See and Touch the MouseMonitor S Today
Come See Us at Our Booth:
Experimental Biology Booth #1546
Editor's Notes
Surgical Monitoring: Generate Consistent Surgical Outcomes & Satisfy your IACUC with the MouseMonitor™ S
Hi everyone, thank you for coming and welcome to this product workshop on Rodent Surgical Monitoring with the MouseMonitor S. What I mean by surgical monitoring is simply continuous monitoring of vital signs the entire duration of surgery preparation, surgery, wrapup and recovery. During the course of the presentation I am going to refer to a mouse or mice many times. I understand that everyone here may not be working with the mouse research model, but may instead be working with rats, bats, naked mole rats, guinea pigs, hamsters, rabbits or other larger animal models. The MouseMonitor S has been tested with all of these animal models and works very well as the core research tool for monitoring the health of the animal with a wide variety of animal species.
Why Surgical Monitoring?
Quick Overview of the Main Steps in Preclinical Rodent Surgeries
The Increasing IACUC Surgical Requirements
How Surgical Monitoring Can Help You in your Many Roles as a Preclinical Researcher
How Surgical Monitoring can improve the consistency of your surgical outcomes
Induce Anesthesia – placing the mouse in an induction chamber
Transfer the mouse to your surgical surface and Stabilize & Maintain Anesthesia
Prepare Subject & Surgical Site for your procedure of interest
Perform Surgical Procedure
Tie up your procedure and begin the process of Recovery from Anesthesia
Protocols Requirements Increasing
We have heard this from many of our users
You may be seeing this at your institution
Requiring More Monitoring
Heart Rate
Respiration Rate
Core Temperature
Blood Oxygenation
Additionally, they are likely Requiring Better Heating
Must be able to adjust to changing lab environmental conditions
Must be able to adjust to changes in heating requirements during surgery
Must be able to provide adequate heating during longer interventions
Finally, many IACUCs are Requiring More Documentation
prove you are following protocol
Researcher and Data Scientist
Anesthesiologist
Surgeon
Person in charge of Quality Control
Person in charge of IACUC Compliance
Monitoring Helps You at Every Step (Better Examples, Improve Notes)
Monitor & See Impact of Every Step in Realtime
Identify Problems Quick Identify When Bad Stuff Happens
Make Intervention Make Timely Intervention
Know When To Cut & Run Evaluate and Make Intervention Endpoint Decision
Provide a Stable Preparation
Ensure Adequate Warming by monitoring Core Temperature
Ensure Appropriate Anesthesia by monitoring Heart & Respiration Rate
Ensure Adequate Ventilation by monitoring Blood Oxygenation
Spot Potential Problems Earlier
Each Sign is Early Indicator that Enables Researcher to Make Intervention
EXAMPLE!!!
Improve Survival Rates
By providing a stable preparation & quickly spotting potential problems you will eliminate many unsuccessful and improve borderline surgeries
This means fewer total surgeries will be required, giving you more time writing your next paper and a happier IACUC
Surgical Monitoring Reduces Variability
Additionally, providing a stable preparation and quickly spotting and responding to problems you reduce the intervention variability and increase the consistency of the outcome under investigation
Doesn’t this already exist in the clinical space?
The devices are known as Integrated Physiologic Monitors
Compact Presentation of Vital Signs
Quick & Immediate Information with Numeric Panels
Detailed Information with Waveforms
Multiple Display Configurations to support different applications
Provides Easy to Use, Actionable Information
Consolidates data display to a single location providing immediacy of information and the ability to generate alarms
Provides immediate & accurate rate, timing & % calculations
Reduces researcher workload, one device to monitor
Increases surgeon’s focus, one device to monitor
compact vital signs presentation simplifies use and helps quickly build the surgeon’s intuitive knowledge of subject health
All about supporting the researcher during surgery
1950 First clinical use of a device that two doctors devised for monitoring the heart during surgery
1954 by ‘54 there were a few companies producing commercial physiologic monitor, initial devices has 3-5” round CRT screens with low phosphor persistence times so the ECG signal looked like bounding ball with a comet tail. Heart rate calculation was not a standard feature and relied on the surgeon to make a mental calculation of heart rate. When it was available it was with a gauge type of display.
60’s – Brought memory tape loops to record data and allowing alarm events to be triggered off of larger data set
Numeric displays using Nixie Tubes
70’s – widespread replacement of tube-based electronics with transistors and solid state technology
Larger 6-8” rectangular CRT displays with no-fade technology
Isolated patient inputs
Variable sweep speed
Heart rate was most commonly reported with a Horizontal bar graph, though some models began to use segmented LED displays
80’s – larger, color CRT displays, hot-swappable modularization and growing network integration
Number of displayed waveforms increased from 2 to 6
90’s – electronics miniaturization and Monochrome LCDs brought about more equipment mobility, the concept of continuum of care came out and hospitals began standardizing on a single manufacturer for the entire hospital’s monitors.
2000’s and beyond – extensive use of microprocessors, LCDs, digital electronics and internet connectivity increases the base level of capability used throughout the hospital and brings the promise of continuum of care full circle.
Initial adoption of Clinical Physiologic Monitors
Spurred on by the VA in 1970 with the release of a document titled “Specifications for Biomedical Monitoring Systems” (X-1414) establishing minimum performance criterion for physiologic monitors.
Nursing, Surgery & Anesthesia professional organizations have continued to Increase these Standards of Care in Decades since
Decreased Recovery Costs
Less ICU Hours
Quicker overall recovery rate
Better Patient Outcomes
Wouldn’t you like to have better data, higher survival rates and quicker recoveries in your lab
These devices have been thoroughly tested on humans and as a result have been deemed safe for use on rodents!
National Research Council’s
Guide for the Care and Use of Laboratory Animals, 8th edition
Released December 2011 includes recommendations that researchers:
Monitor Heart Rate
Monitor Respiration Rate
Monitor Core Temperature
Monitor Blood Oxygenation
Document Surgeries
Adoption by International Lab Animal Organizations
AALAS
AAALAC
Other International Lab Animal Care Organizations
Harness Clinical Advancements
The MouseMonitor S is the first Preclinical Integrated Rodent Physiologic Monitor
Move your lab from 50’s technology directly into the modern age
Stay Ahead of the curve and:
Reduce Mortality
Use Fewer Mice
Perform fewer surgeries
Improve Surgical Consistency
Monitor & control variables
Identify Problems Faster
Enable effective in-surgery interventions
Additional Research Focused Features
To satisfy unique rodent preclinical research needs
Responsive Heating
Rigid Surgical Platform
Screenshot, Recording & Recording Playback Functionality
Reduce data variability
Preclinical researchers have a different set of needs and requirements
Surface Electrodes
Allows continuous, Heart Rate & Respiration Rate monitoring from same electrodes
Quick & easy, just tape and go, no repositioning even for long sessions
Works well in non-ideal conditions. Eg: low oxygen, low temperature
Rectal Probe
Allows continuous, NI Core Temperature monitoring
Accepted standard among preclinical researchers, used for many years
Thigh or Foot Clip
Allows continuous, NI Blood Oxygenation monitoring
Quick attachment
The benefits of Non-Invasive Monitoring include:
less Site & Sterilization Preparation time
Less Infection Risk and No Monitoring-Related Injury Burden
Zone-Based Electronic Heating
Heating Output adapts to animal and surgery needs
Heating Output adapts to lab room conditions (eg. under an AC Vent)
More Responsive than Water-Based Heating Pads
More Responsive & More Even Heating Than Resistive Elements/Pads
Ready to run in 2 Minutes, >10x faster than Water & Resistive that takes 20-30min
Animal Safety is our Priority
Built-In Pad Temperature Sensor
Built-In Closed Loop Feedback control, no additional sensors needed
Safety first with hardware cutout limits
Safety first, never regulates off of core temp
Rigid, Stable Work Surface
Rigid surface makes it easy to prepare & position Animal for surgery
Stable, stationary surface gives a firm base for surgeries
Easily Cleanable & Sterilizable
Surgery can be messy, nonabsorbent surface designed for surgery
SS Platform easily cleanable with water, saline or alcohol
SS Platform easily sterilizable with Cidex, CaviCide
Durable Surgical SS Platform & Electrodes will take years of abuse
Enough Space to Rest Hands
Comfortable, low hand strain
Hands can rest on platform, have support during surgery
Nice temperature, hand rest areas don’t heat up
High Resolution Signals
High Sample Rates
State of the art digitization
Low Noise Electronics Design
Designed to work well in noisy lab environments
Designed to work with other manufacturer’s instruments
Multiple Signal & Power Supply Isolation Zones
Multiple Grounding Methods
Multiple Filtering Techniques
Non-interfering Modalities
Designed to handle & integrate multiple signals
MouseMonitor S expansion modules work well together
MouseMonitor S expansion modules enable easy expansion of capabilities
Full Resolution Analog Output
4 Channels of High Resolution, Low Latency Analog Output Included
An additional 8 Channels of High Resolution Analog Output Available
Screenshots
Take Publication-ready screenshots with a Single Button Press
Records Experimental Setup. Study & researcher names, filters
Includes Timestamp
Screenshots
Take Publication-ready screenshots with a Single Button Press
Records Experimental Setup. Study & researcher names, filters
Includes Timestamp
Recordings & Playback
Capture a Full resolution recording of all signals with a Single Button Press
Play back recordings to
Review recorded data
Quickly spot areas of interest
Scan recorded Files to Quickly review files faster than realtime
Recordings & Playback
Capture a Full resolution recording of all signals with a Single Button Press
Play back recordings to
Review recorded data
Quickly spot areas of interest
Scan recorded Files to Quickly review files faster than realtime
Very Usable & Very Capable Tool
Big difference between a device that works and one that is easy to use
Saw a lot of unused devices in the lab simply because they were difficult or time consuming to use
Devices need to be easy to use, not just technically capable
Quick Setup
Initial setup, go from packed in the box to monitoring in less than an hour
Daily use, load presets & prepare a sedated mouse in less than a minute
Touch User Interface
Simple gesture controls scale waveforms
Controls & settings all in one place
Powerful Presets
8 Lab-Tested, Ready-To-Use Factory Presets for a wide variety of studies & applications
Stores EVERY configuration value
Easily create User & Study Presets
Gets you up and running quickly every time
Preclinical Surgery is Challenging
In addition to lots of anesthesia & research responsibilities, Preclinical surgery places a lot of physical and mental demands on the surgeon, demanding precise manipulation of very small physiology while dealing with potentially very fast changes in patient condition
Critical Data All in one Place
Quickly see Core Temperature, Heart Rate & Respiration Rate so you can easily notice a early drop in temperature or heart rate that is a sign of deteriorating subject condition
Instead of looking at multiple devices spread across your lab bench all of the critical subject condition information is in one place on one device
This gives you the ability to intervene and stabilize subject condition before continuing, stopping potential problems in their tracks before they get out of control
Enables you to return your mental focus to the challenging surgery
Flexibility
Different Animals (Mice, rats, bats, naked mole rats & many larger animals)
Different Types of Studies with different views & settings
Grows with your Lab
Training Tool to help new surgeons develop intuitive knowledge of the subject’s condition in addition to physical surgical skills
Helps coordinate research in larger labs by helping to provide uniform experimental conditions and making it easy to create & share standard experiment presets
Expansion modules allow you to easily build your lab’s capabilities as needs increase
Doesn’t require complicated and expensive data acquisition hardware and software when you need to add another instrument
Current Modules: Analog Output & Pulse Oximeter
Upcoming Modules: Invasive Pressure, OEM partnerships & ongoing development
Great Value
Costs 50% less than an unintegrated system of many parts and works better
Cheapest way to get high resolution, publication quality data
Cheapest way to build your capabilities over time
Only way to get a standalone system that lets you document your studies with screenshots and recordings
Whether your needs any particular moment are:
Researcher - Provides you with high quality data, screenshots, records
Anesthesiologist - Improves your anesthesia delivering skills, insuring a stable base preparation
Surgeon - Enables you to focus on surgery
QA/QC & IACUC Compliance Officer - Reduces the time you spend documenting surgeries
The MouseMonitor S is a research tool that gives you critical information that is clearly presented to help improve surgical outcomes and make it easier for you to tell the story of your research
Improves Surgical Outcomes
By bringing the advancements of modern clinical technology to our lab you can:
Improve your research outcomes by improving surgical consistency and decreasing study variability
More easily collect research quality data
Comply with increased IACUC research protocol requirements
IMAGE: GRAHAM MUGSHOT, COME SEE US CARTOON
Questions
Have link and QR Code of Specific Web Address of Download Location
Handouts – 4 slides/page
