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Cell Division and Genetics – Mechanisms for a Knit of Identity and Thread of Distinction
DNA and Its Faithful Replication – The Knit of Identity Because DNA stores genetic information and is faithfully replicated, information is passed largely unaltered from cell-to-cell, generation-to- generation.
Proteins and Their Production – The Primary Reason for DNA
Cell Division Demands Coordination of DNA Replication, Mitosis and Cytokinesis What’s so important about cell division?
Cell division requires coordinated division of chromosomes (mitosis) ….. ……  and division of the cytoplasm (cytokinesis).
DNA Replication – Simple in Principle, Complicated in Practice
DNA is Packaged into Chromosomes DNA in the cell is virtually always associated with proteins. The packaging is impressive – 2 meters of human DNA fit into a sphere about 0.000005 meters in diameter. chromatin duplicated chromosome
The Link Between DNA Replication and Chromosome Duplication
DNA is Condensed into Visible Chromosomes Only For Brief Periods in the Life of a Cell 95% of the time, chromosomes are like this. Easily visible chromosomes are apparent perhaps 5%  of the time in an actively growing cell and less in a non-growing cell.
A Karyotype is an Arranged Picture of Chromosomes At Their Most Condensed State A normal human karyotype Boy or girl? Note that almost all chromosomes come in homologous pairs.
From Birth to Rebirth, a Cell Progresses Through Characteristic Stages That Constitute the Cell Cycle In multicellular organisms like us, progress through the cell cycle is carefully regulated.
Cancer Is One Outcome of A Runaway Cell Cycle Licentious division - prostate cancer cells during division.
The Knit of Identity - Mitosis Precisely and Evenly Divides Duplicated Chromosomes Precisely dividing the duplicated chromosomes has the consequence of providing each new cell with an identical and complete set of genetic instructions. interphase prophase metaphase
Mitosis Precisely and Evenly Divides Duplicated Chromosomes Cytokinesis is the process of cell division and it is distinct and separable from mitosis.
Mitosis in Action Blue shows DNA, green shows spindle fibers.
In Animal Cells, a Cleavage Furrow Forms and Separates Daughter Cells Cleave furrow in a dividing frog cell.
The Plant Cell Wall Forces Cytokinesis to Play by Different Rules
Part 1: Cell Division ,[object Object],[object Object]
Prokaryotic Chromosomes ,[object Object],[object Object]
Chromosomes  ( colored bodies )   ,[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Eukaryotic Chromosomes ,[object Object]
Mitosis   ,[object Object],[object Object],[object Object]
Chromosomes (colored bodies)   ,[object Object]
Human Chromosomes: 46   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mitosis and Interphase Alternate   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chromosomes cont.   Homologous pair (2n, diploid) in parent cell ,[object Object],One of each pair to  daughter cell Copies
Mitosis is a Continuum
Prophase   ,[object Object],Under a light microscope, only the nuclear envelope (with nucleoli) and a tangle of chromatin are visible
Pro-metaphase  (late prophase) ,[object Object],[object Object]
Metaphase   ,[object Object]
Anaphase  ,[object Object],[object Object]
Telophase   ,[object Object],[object Object]
Cytokinesis   ,[object Object]
Phases of the Cell Cycle ,[object Object],[object Object],[object Object],[object Object],INTERPHASE G 1 S (DNA synthesis) G 2 Cytokinesis Mitosis MITOTIC (M) PHASE Figure 12.5
[object Object],[object Object],[object Object],[object Object],Figure 13.1
[object Object],[object Object],[object Object]
Inheritance of Genes ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Comparison of Asexual and Sexual Reproduction  ,[object Object],[object Object],Figure 13.2 Parent Bud 0.5 mm
[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Behavior of Chromosome Sets in the Human Life Cycle ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Figure 13.7 Interphase Homologous pair of chromosomes in diploid parent cell Chromosomes replicate Homologous pair of replicated chromosomes Sister chromatids Diploid cell with replicated chromosomes 1 2 Homologous chromosomes separate Haploid cells with replicated chromosomes Sister chromatids separate Haploid cells with unreplicated chromosomes Meiosis I Meiosis II
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Newborn (2n) Growth Development Maintenance Repair Gametogenesis Adult (2n) Growth Development Maintenance Repair Mitosis Gametes Egg (n) Sperm (n) Meiosis Zygote (2n) Embryo (2n) Mitosis Growth Development Maintenance Repair Mitosis Growth Mitosis
[object Object],[object Object]
Origins of Genetic Variation Among Offspring ,[object Object],[object Object]
Independent Assortment of Chromosomes ,[object Object],[object Object]
[object Object],[object Object],Figure 13.10 Key Maternal set of chromosomes Paternal set of chromosomes Possibility 1 Two equally probable  arrangements of chromosomes at metaphase I Possibility 2 Metaphase II Daughter cells Combination 1 Combination 2 Combination 3 Combination 4
[object Object],Figure 13.8 Centrosomes (with centriole  pairs) Sister chromatids Chiasmata Spindle Tetrad Nuclear envelope Chromatin Centromere (with kinetochore) Microtubule attached to kinetochore Tetrads line up Metaphase plate Homologous chromosomes separate Sister chromatids remain attached Pairs of homologous chromosomes split up Chromosomes duplicate Homologous chromosomes (red and blue) pair and exchange segments;  2 n  = 6 in this example INTERPHASE MEIOSIS I: Separates homologous chromosomes PROPHASE I METAPHASE I ANAPHASE I
[object Object],TELOPHASE I AND CYTOKINESIS PROPHASE II METAPHASE II ANAPHASE II TELOPHASE II AND CYTOKINESIS MEIOSIS II: Separates sister chromatids Cleavage furrow Sister chromatids separate During another round of cell division, the sister chromatids finally separate; four haploid daughter cells result, containing single chromosomes Two haploid cells form; chromosomes are still double Haploid daughter cells forming Figure 13.8
[object Object],Figure 13.9 MITOSIS MEIOSIS Prophase Duplicated chromosome (two sister chromatids) Chromosome replication Chromosome replication Parent cell (before chromosome replication) Chiasma (site of crossing over) Prophase I Tetrad formed by synapsis of homologous chromosomes Metaphase Chromosomes positioned at themetaphase plate Tetrads positioned at the metaphase plate Metaphase I Anaphase I Telophase I Haploid n  = 3 MEIOSIS II Daughter cells of meiosis I Homologues separate during anaphase I; sister chromatids remain together Daughter cells of meiosis II n n n n Sister chromatids separate during anaphase II Anaphase Telophase Sister chromatids separate during anaphase 2 n 2 n Daughter cells of mitosis 2 n  = 6 MEIOSIS I
A Comparison of Mitosis and Meiosis ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Mitosis and cytokinesis

  • 1. Cell Division and Genetics – Mechanisms for a Knit of Identity and Thread of Distinction
  • 2. DNA and Its Faithful Replication – The Knit of Identity Because DNA stores genetic information and is faithfully replicated, information is passed largely unaltered from cell-to-cell, generation-to- generation.
  • 3. Proteins and Their Production – The Primary Reason for DNA
  • 4. Cell Division Demands Coordination of DNA Replication, Mitosis and Cytokinesis What’s so important about cell division?
  • 5. Cell division requires coordinated division of chromosomes (mitosis) ….. …… and division of the cytoplasm (cytokinesis).
  • 6. DNA Replication – Simple in Principle, Complicated in Practice
  • 7. DNA is Packaged into Chromosomes DNA in the cell is virtually always associated with proteins. The packaging is impressive – 2 meters of human DNA fit into a sphere about 0.000005 meters in diameter. chromatin duplicated chromosome
  • 8. The Link Between DNA Replication and Chromosome Duplication
  • 9. DNA is Condensed into Visible Chromosomes Only For Brief Periods in the Life of a Cell 95% of the time, chromosomes are like this. Easily visible chromosomes are apparent perhaps 5% of the time in an actively growing cell and less in a non-growing cell.
  • 10. A Karyotype is an Arranged Picture of Chromosomes At Their Most Condensed State A normal human karyotype Boy or girl? Note that almost all chromosomes come in homologous pairs.
  • 11. From Birth to Rebirth, a Cell Progresses Through Characteristic Stages That Constitute the Cell Cycle In multicellular organisms like us, progress through the cell cycle is carefully regulated.
  • 12. Cancer Is One Outcome of A Runaway Cell Cycle Licentious division - prostate cancer cells during division.
  • 13. The Knit of Identity - Mitosis Precisely and Evenly Divides Duplicated Chromosomes Precisely dividing the duplicated chromosomes has the consequence of providing each new cell with an identical and complete set of genetic instructions. interphase prophase metaphase
  • 14. Mitosis Precisely and Evenly Divides Duplicated Chromosomes Cytokinesis is the process of cell division and it is distinct and separable from mitosis.
  • 15. Mitosis in Action Blue shows DNA, green shows spindle fibers.
  • 16. In Animal Cells, a Cleavage Furrow Forms and Separates Daughter Cells Cleave furrow in a dividing frog cell.
  • 17. The Plant Cell Wall Forces Cytokinesis to Play by Different Rules
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28. Mitosis is a Continuum
  • 29.
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  • 46.
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  • 48.
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  • 51. Newborn (2n) Growth Development Maintenance Repair Gametogenesis Adult (2n) Growth Development Maintenance Repair Mitosis Gametes Egg (n) Sperm (n) Meiosis Zygote (2n) Embryo (2n) Mitosis Growth Development Maintenance Repair Mitosis Growth Mitosis
  • 52.
  • 53.
  • 54.
  • 55.
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  • 58.
  • 59.

Editor's Notes

  1. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  2. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  3. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  4. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  5. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  6. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  7. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  8. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  9. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  10. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  11. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  12. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  13. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  14. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  15. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  16. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010
  17. Genes, Mitosis and Cytokinesis 01/19/11 G. Podgorski, Biol. 1010