The winning pitch for 2020 MIT Hacking Medicine - Customized Cancer Care track

1. Onco Twin - Digital Tumor
Twin for Glioblastoma Patients
Helena Deus, Shakson Isaac, Mike Rizzo, Bhushan Venkatesh
Biologist w/
focus on cancer
(Boston)
Biochemistry and
applied math
(California)
ECE
(Boston)
Mechatronics
(Bangalore)

3. Integration of topological-
genomic model into the
EHR
Onco Twin: data-driven 3D modeling platform
Tracking evolution of glioblastoma
‘Omics models integrated
with the 3D model
Patient is diagnosed with
glioblastoma
Lee, W., Huang, D. S., & Han, K. (2020). Constructing cancer patient-specific
and group-specific gene networks with multi-omics data. BMC medical
genomics, 13(Suppl 6), 81. https://doi.org/10.1186/s12920-020-00736-7
Brain MRI literature review for interdisciplinary studies -
Scientific Figure on ResearchGate. Available from:
ttps://www.researchgate.net/figure/Voxel-and-slice-in-3D-
MRI-data_fig8_280608869 [accessed 4 Oct, 2020]

5. Gene network validation
Business Model: Pre-clinical and clinical validation
MVP
3D model validation
Public data
Animal model validation
Clinical Trial in
glioblastoma
Commercialization
Phase IV Trial -
other tumor types
1 year
6 months
6 months
“Digital Twin”
center of
excellence

6. Onco Twin - one platform, numerous applications