This document provides an overview of tuberculosis (TB) including its definition, causative agent, risk factors, epidemiology, pathophysiology, diagnosis, treatment and management, and desired outcomes. TB is caused by the bacterium Mycobacterium tuberculosis and produces latent, silent infections that can develop into active, progressive disease. It is diagnosed through tests such as tuberculin skin tests, sputum smears, chest radiography, and nucleic acid amplification. Treatment involves a multi-drug regimen over a period of 6-9 months with first-line antibiotics like isoniazid, rifampin, pyrazinamide, and ethambutol. Management also includes measures like proper nutrition, not smoking/dr
8. RISK FACTORS OF TUBERCULOSIS
Co infection with Human immunodeficiency Virus (HIV)
Crowded living conditions
Immunosuppressants
Migration from a country with a high number of TB cases
Alcoholism
Cancer of the head and neck
Smoking - Smokers who develop TB should be encouraged to
stop smoking to decrease the risk of relapse
10. EPIDEMIOLOGY
Roughly one of every three people is infected by M.
Tuberculosis
High incidence of TB in Southern Asia and Sub – Saharan Africa
59% of TB patients in United State are foreign born , most
often from Mexico , Philippines , Vietnam , India
With The Spread of AIDS , TB continues to lay waste to large
populations
The emergency of drug resistant organism threatens to make
this disease once again incurable
23. TREATMENT AND MANAGEMENT
FIRST LINE
ANTI TB
RIFAMYCINS
ISONIAZID
PYRAZINAMIDE
ETHAMBUTOL
SECOND LINE
ANTI TB
QUINOLONES
STREPTOMYCIN
KANAMYCIN
MACROLIDES
CYCLOSERINE
ETHIONAMIDE
27. TREATMENT – LATENT TB
ISONIAZID
9 MONTHS >30KG PO qDAY
TREATMENT IN HIV NEGATIVE
ISONIAZID +
RIFAPENTENE
3 MONTHS PO 900MG
ONCE WEEKLY
TREATMENT IN HIV HEALTHY NOT
TAKING ANTI RETROVIRAL THERAPY
29. NON PHARMACOLOGICAL
WHAT TO EAT
VEGETABLE WITH HIGH Fe+
& VIT B CONTENT
BRIGHT (RED) VEGETABLES
VEGETABLE OIL
WHOLE GRAIN
NOT TO EAT
ALCOHOL
TOBACO IN ALL FORM
SUGAR (REFINED PRODUCTS)
WHITE BREAD
HIGH FAT DIET
HIGH CHOLESTEROL
RED MEAT
32. TREATMENT OF MDR TB
UTILIZE ATLEAST 3-5
UNUSED DRUGS
LEVOFLOXACIN
DON’T ADD DRUG IN
FAILED REGIMEN
ADD 3 PREFFERABLE
MEDICINES FROM
FOLLOWING
AMINOGLYCOSIDE
FLUOROQUINONE
THIONAMIDE
CYCLOSERINE
BEDAQUILINE
33. Treatment options are very limited
Carries a very high mortality rate
TREATMENT OF MDR TB
34. DESIRED
OUTCOMES
RAPID IDENTIFICATION OF NEW CASES OF TB
INITIATION OF SPECIFIC ANTI TUBERSULOSIS TREATMENT
PROMPT RESOLUTION OF SIGN AND SYMPTOM OF
DISEASE
ADHERENCE THE TREATMENT REGIMEN BY THE PATIENT
CURE AS QUICKLY AS POSSIBLE