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By
Hassaan A. Gad
Assistant Lecturer of urology
Aswan University , Egypt
hassaan.ali@aswu.edu.eg
POSTOPRATIVE SURGICAL
COMPLICATIONS
Classification systems of surgical
complications
 Clavien-Dindo grading system.
 MSKCC = Memorial Sloan-Kettering Cancer
Centre classification - modification of the
original T92 Clavien classification
 NSQIP = National Surgical Quality
Improvement Programme
 NCT-CTC = National Cancer Institute
Common Toxicity Criteria
 Accordion :contracted/extended
hassaan.ali@aswu.edu.eg
Clavien-Dindo grading system
 Grade I Any deviation from the normal postoperative course
without the need for pharmacological treatment or surgical,
endoscopic, and radiological interventions.
 Grade II Requiring pharmacological treatment with drug other
than such allowed for Grade I complications.
 Grade III Requiring surgical, endoscopic or radiological
intervention.
Grade IIIa Intervention not under general anaesthesia.
Grade IIIb Intervention under general anaesthesia.
 Grade IV Life-threatening complication.
Grade IVa Single organ dysfunction.
Grade IVb Multi organ dysfunction.
 Grade V Death of a patient.
 Suffix “d” If the patient suffers from a complication at the time of
discharge .
hassaan.ali@aswu.edu.eg
Classification
 Wound
 Thermal regulation
 Postoperative fever
 Pulmonary
 Cardiac
 Gastrointestinal
 Metabolic
 Neurological
Immediate/Early/Late
Systemic:
 Neurological
 Respiratory
 Cardiovascular
 Gastrointestinal
 Urological
 Endocrine
 Haematological
hassaan.ali@aswu.edu.eg
POSTOPERATIVE FEVER
hassaan.ali@aswu.edu.eg
TYPES OF POSTOPERATIVE
FEVER
 INTERMITTENT
 Intermittent elevation of temp with regular return to
normal temp (infection within closed space-
abscess)
 REMITTENT/FLUCTUATING
Continuous type of fever drop in fever without
returning to normal
-brucellosis, blood stream infections, infected
arterial grafts, phlebitis.
 UNREMITTING/CONTINUOUS
Continuous high fever-CNS injury, pneumonias,
typhoid.hassaan.ali@aswu.edu.eg
CAUSES OF POST-OP FEVER
THE 5 ‘W’ OF POST-OP FEVER
 1.Wind Atelectasis, pneumonia

 2.Water UTI
 3.Wound Wound/Surgical site infection,
Abscess, Anastomotic leak, Lines (IVC, CVC,
drains, )
 4.Walking DVT / PE
 5.Wonder drugs
hassaan.ali@aswu.edu.eg
FIRST DAY FEVER (24 – 48
HRS.)
 ATELACTASIS
 PNEUMONITIS
hassaan.ali@aswu.edu.eg
ATELACTASIS
Anesthesia agents cause increase production
of secretions, as water evaporates, they
become viscous. with diminished cough reflex
& decrease ciliary activity - formation of
mucus plug- obstruct small airways.
When the gases distal to plug get absorbed
the airways collapse.
Febrile response is due to Low grade infection
distal to obstructing plug and absorption of
bacterial pyrogens
Temp elevation within 12 hrs of onset of plug
formation.max temp is characteristically 38.9
degree centigradehassaan.ali@aswu.edu.eg
PNEUMONITIS
High risk group - Cigarette smoking, chronic
bronchitis, COPD
Prevention:
 Assessment of patient,
 Avoid General Anaesthesia,
 Stop smoking,
 Spirometery ,
 Assess pulmonary mechanics,
 Chest physiotherapy,
 Early mobilization
hassaan.ali@aswu.edu.eg
THIRD DAYS URGICAL FEVER 48-
72HRS
CAUSES
Temp elevation to 40.6-41. 1°C
 PHLEBITIS
 IV catheter sepsis
 DVT and Pulmonary embolism
 Suppurative thrombophlebitis
hassaan.ali@aswu.edu.eg
PHLEBITIS
 Tachycardia, Hypotension, Oliguria,, Leukocytosis,
 septic shock develop 52%.
 Mortality rate 40% in above age 40yrs, and 80% in
above age 80yrs.
 Tenderness and erythema around catheter.
 Precipitating causes:
 Hyperosmolar infusate,
 Antibiotics ,
 size of vein in which catheter.
 This can be decreased by adding one unit of heparin.
 IV septic technique
 Cathater sepsis reduced from 23% to 4% if IV
catheter placed for max 12 hrs.
hassaan.ali@aswu.edu.eg
IV catheter sepsis
 Lack of aseptic technique
 Use of hypertonic solutions
 Multiple infusions through same line
 Change of site after 72 hrs.
hassaan.ali@aswu.edu.eg
Third and Fourth DAY fever
DVT
 PUL. EMBOLISM
hassaan.ali@aswu.edu.eg
DVT
Diagnosis
 3 -4 days Temp elevation, calf Tenderness
(Homan’s sign)
 Doppler ultrasound, has replaces contrast
venograms
Treatment is PREVENTION
 Identify High risk group from pre-op stage.
 Start prophylactic heparin sub cut peri-operative
 Mechanical means
hassaan.ali@aswu.edu.eg
PULMONARY EMBOLISM
Sequelae of DVT
Fever does not appear until pul thrombo
embolisation-pain chest, dyspnoea,
Treatment is prevention
Therapeutic dose of heparin
need hdu
hassaan.ali@aswu.edu.eg
SUPPURATIVE THROMBO
PHLEBITIS
 Presence of suppurative infection in vein is often
lethal-need ligation of vein
 high fever , remittent type
 common sites are; basilic,cephalic, neck veins
 occasionally seen in pelvic veins after septic
abortion,
hassaan.ali@aswu.edu.eg
URINARY TRACT INFECTIONS
 Most common nosocomial infection (40%)
 75% patients have some form of urine tract
manipulation
 Bacteria found in urine in 1-5% of patients
undergoing short term catheterization, 90% pts in
whom Foley is left for 48hrs or more
 Post op UTI; temp 39.4-40°C, rigors/chills
Management –
 prevention, Catheter insertion only when must,
 Aseptic technique , closed drainage system.
 Discard drainage system if accidentally
disconnected and change when obstruction or
contamination occurs.hassaan.ali@aswu.edu.eg
DAY 5-8 FEVER Surgical wound
infection
Wound infection‘ present as abscess-cellulites
 Signs of erythema, foul discharge, indurations,
soakage
Treatment is adequate drainage &/antibiotic
coverage
 Factors responsible-patient related , disease
related, procedure related, environment related.
 Lack of preventive measures.
hassaan.ali@aswu.edu.eg
BENIGN POST OPERATIVE
FEVER
 During Operation Thermo regulatory mechanism
Hypothalamus becomes inhibited by Anesthetic
agents –fall in body temp,
 Once anesthesia effect is gone- recovery of this
mechanism but intracranial core temp still decreased-
thermosenstive receptors in hypothalamus sense
decreased temp and attempt to raise body temp to
hypothalic set point, often there is over compensation
with a mild febrile episode in post op period
 This is diagnosed by exclusion
hassaan.ali@aswu.edu.eg
OTHER CAUSES
HYPER METABOLISM -increased BMR in
response to surgery –burn pt, returns to normal
with wound healing
DRUG induced fever
DEHYDRATION-decreased sensitivity to
sweating mechanism
MALIGNANT HYPERTHERMIA
THYROID STORM
FEVER OF CNS ORIGIN
hassaan.ali@aswu.edu.eg
DRUGS THAT CAUSE FEVER
due to effects of pharmacological activity;
Antibiotics, Cytotoxic agents
Drugs causing fever due altered
thermoregulation
 Atropine, Catacholamines, (Decrease sweating)
 Increased BMR- thyroxine derivatives
Drugs causing fever due to contaminants;
IV solutions
Drugs causing fever due to hypersensitivity-
sulphas, penicillins,
hassaan.ali@aswu.edu.eg
Malignant hyperthermia
 Autosomal dominant, rare
 Presentation: fever, tachycardia, rigidity,
cyanosis
 Treatment: Dantrolene 1 to 2 mg/kg 10 mg/kg
total until symptoms subside
hassaan.ali@aswu.edu.eg

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POSTOPRATIVE SURGICAL COMPLICATIONS

  • 1. By Hassaan A. Gad Assistant Lecturer of urology Aswan University , Egypt hassaan.ali@aswu.edu.eg POSTOPRATIVE SURGICAL COMPLICATIONS
  • 2. Classification systems of surgical complications  Clavien-Dindo grading system.  MSKCC = Memorial Sloan-Kettering Cancer Centre classification - modification of the original T92 Clavien classification  NSQIP = National Surgical Quality Improvement Programme  NCT-CTC = National Cancer Institute Common Toxicity Criteria  Accordion :contracted/extended hassaan.ali@aswu.edu.eg
  • 3. Clavien-Dindo grading system  Grade I Any deviation from the normal postoperative course without the need for pharmacological treatment or surgical, endoscopic, and radiological interventions.  Grade II Requiring pharmacological treatment with drug other than such allowed for Grade I complications.  Grade III Requiring surgical, endoscopic or radiological intervention. Grade IIIa Intervention not under general anaesthesia. Grade IIIb Intervention under general anaesthesia.  Grade IV Life-threatening complication. Grade IVa Single organ dysfunction. Grade IVb Multi organ dysfunction.  Grade V Death of a patient.  Suffix “d” If the patient suffers from a complication at the time of discharge . hassaan.ali@aswu.edu.eg
  • 4. Classification  Wound  Thermal regulation  Postoperative fever  Pulmonary  Cardiac  Gastrointestinal  Metabolic  Neurological Immediate/Early/Late Systemic:  Neurological  Respiratory  Cardiovascular  Gastrointestinal  Urological  Endocrine  Haematological hassaan.ali@aswu.edu.eg
  • 6. TYPES OF POSTOPERATIVE FEVER  INTERMITTENT  Intermittent elevation of temp with regular return to normal temp (infection within closed space- abscess)  REMITTENT/FLUCTUATING Continuous type of fever drop in fever without returning to normal -brucellosis, blood stream infections, infected arterial grafts, phlebitis.  UNREMITTING/CONTINUOUS Continuous high fever-CNS injury, pneumonias, typhoid.hassaan.ali@aswu.edu.eg
  • 7. CAUSES OF POST-OP FEVER THE 5 ‘W’ OF POST-OP FEVER  1.Wind Atelectasis, pneumonia   2.Water UTI  3.Wound Wound/Surgical site infection, Abscess, Anastomotic leak, Lines (IVC, CVC, drains, )  4.Walking DVT / PE  5.Wonder drugs hassaan.ali@aswu.edu.eg
  • 8. FIRST DAY FEVER (24 – 48 HRS.)  ATELACTASIS  PNEUMONITIS hassaan.ali@aswu.edu.eg
  • 9. ATELACTASIS Anesthesia agents cause increase production of secretions, as water evaporates, they become viscous. with diminished cough reflex & decrease ciliary activity - formation of mucus plug- obstruct small airways. When the gases distal to plug get absorbed the airways collapse. Febrile response is due to Low grade infection distal to obstructing plug and absorption of bacterial pyrogens Temp elevation within 12 hrs of onset of plug formation.max temp is characteristically 38.9 degree centigradehassaan.ali@aswu.edu.eg
  • 10. PNEUMONITIS High risk group - Cigarette smoking, chronic bronchitis, COPD Prevention:  Assessment of patient,  Avoid General Anaesthesia,  Stop smoking,  Spirometery ,  Assess pulmonary mechanics,  Chest physiotherapy,  Early mobilization hassaan.ali@aswu.edu.eg
  • 11. THIRD DAYS URGICAL FEVER 48- 72HRS CAUSES Temp elevation to 40.6-41. 1°C  PHLEBITIS  IV catheter sepsis  DVT and Pulmonary embolism  Suppurative thrombophlebitis hassaan.ali@aswu.edu.eg
  • 12. PHLEBITIS  Tachycardia, Hypotension, Oliguria,, Leukocytosis,  septic shock develop 52%.  Mortality rate 40% in above age 40yrs, and 80% in above age 80yrs.  Tenderness and erythema around catheter.  Precipitating causes:  Hyperosmolar infusate,  Antibiotics ,  size of vein in which catheter.  This can be decreased by adding one unit of heparin.  IV septic technique  Cathater sepsis reduced from 23% to 4% if IV catheter placed for max 12 hrs. hassaan.ali@aswu.edu.eg
  • 13. IV catheter sepsis  Lack of aseptic technique  Use of hypertonic solutions  Multiple infusions through same line  Change of site after 72 hrs. hassaan.ali@aswu.edu.eg
  • 14. Third and Fourth DAY fever DVT  PUL. EMBOLISM hassaan.ali@aswu.edu.eg
  • 15. DVT Diagnosis  3 -4 days Temp elevation, calf Tenderness (Homan’s sign)  Doppler ultrasound, has replaces contrast venograms Treatment is PREVENTION  Identify High risk group from pre-op stage.  Start prophylactic heparin sub cut peri-operative  Mechanical means hassaan.ali@aswu.edu.eg
  • 16. PULMONARY EMBOLISM Sequelae of DVT Fever does not appear until pul thrombo embolisation-pain chest, dyspnoea, Treatment is prevention Therapeutic dose of heparin need hdu hassaan.ali@aswu.edu.eg
  • 17. SUPPURATIVE THROMBO PHLEBITIS  Presence of suppurative infection in vein is often lethal-need ligation of vein  high fever , remittent type  common sites are; basilic,cephalic, neck veins  occasionally seen in pelvic veins after septic abortion, hassaan.ali@aswu.edu.eg
  • 18. URINARY TRACT INFECTIONS  Most common nosocomial infection (40%)  75% patients have some form of urine tract manipulation  Bacteria found in urine in 1-5% of patients undergoing short term catheterization, 90% pts in whom Foley is left for 48hrs or more  Post op UTI; temp 39.4-40°C, rigors/chills Management –  prevention, Catheter insertion only when must,  Aseptic technique , closed drainage system.  Discard drainage system if accidentally disconnected and change when obstruction or contamination occurs.hassaan.ali@aswu.edu.eg
  • 19. DAY 5-8 FEVER Surgical wound infection Wound infection‘ present as abscess-cellulites  Signs of erythema, foul discharge, indurations, soakage Treatment is adequate drainage &/antibiotic coverage  Factors responsible-patient related , disease related, procedure related, environment related.  Lack of preventive measures. hassaan.ali@aswu.edu.eg
  • 20. BENIGN POST OPERATIVE FEVER  During Operation Thermo regulatory mechanism Hypothalamus becomes inhibited by Anesthetic agents –fall in body temp,  Once anesthesia effect is gone- recovery of this mechanism but intracranial core temp still decreased- thermosenstive receptors in hypothalamus sense decreased temp and attempt to raise body temp to hypothalic set point, often there is over compensation with a mild febrile episode in post op period  This is diagnosed by exclusion hassaan.ali@aswu.edu.eg
  • 21. OTHER CAUSES HYPER METABOLISM -increased BMR in response to surgery –burn pt, returns to normal with wound healing DRUG induced fever DEHYDRATION-decreased sensitivity to sweating mechanism MALIGNANT HYPERTHERMIA THYROID STORM FEVER OF CNS ORIGIN hassaan.ali@aswu.edu.eg
  • 22. DRUGS THAT CAUSE FEVER due to effects of pharmacological activity; Antibiotics, Cytotoxic agents Drugs causing fever due altered thermoregulation  Atropine, Catacholamines, (Decrease sweating)  Increased BMR- thyroxine derivatives Drugs causing fever due to contaminants; IV solutions Drugs causing fever due to hypersensitivity- sulphas, penicillins, hassaan.ali@aswu.edu.eg
  • 23. Malignant hyperthermia  Autosomal dominant, rare  Presentation: fever, tachycardia, rigidity, cyanosis  Treatment: Dantrolene 1 to 2 mg/kg 10 mg/kg total until symptoms subside hassaan.ali@aswu.edu.eg