2. • The thalassemias are a group of hereditary anemias characterized by
hypochromia (an abnormal decrease in the hemoglobin content of
erythrocytes), extreme microcytosis (smaller-than-normal erythrocytes),
destruction of blood elements (hemolysis), and variable degrees of
anemia.
• The thalassemias occur worldwide, but the highest prevalence is found in
people of Mediterranean, African, and Southeast Asian ancestry.
• Haemoglobin, a molecule found inside blood cells (RBCs) that transports
oxygen the body. Consequently, Red Blood Cells synthesis is also
impaired.
INTRODUCTION
3. DEFINITION
• “Thalassemia is a group
of inherited disorders of
hemoglobin synthesis is
characterized by reduced
or absent one or more of
the globin chains of
hemoglobin.”
