Glycolysis

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AADHIBHAGAWAN COLLEGE OF PHARMACY, THIRUVANNAMAI, TAMIL NADU

carbohydrate cycle , glycolysis cycle , carbohydrate ,

Health & Medicine

Glycolysis
Glucose
Pyruvate Lactate
10 steps
No O2
Energy (ATP) and metabolites
3 regulated steps

Pathway Overview
 What does glycolysis do for us?
•Process Glc (Frc) monomers
•Form 3-C metabolites
•Generate ATP and NADH
•Input to Glycogen, PPP
TCA
PPP
Glycogen
ATP
ATP
NADH
Glc
G6P
F6P
F16BP
DHAP + G3P
1,3-BPG
3-PG
2-PG
PEP
Pyr
•Input to TCA cycle
Lactate
PGK
PK (reg)
G3P DH
LDH
HK (reg)
PFK-1 (reg)
•Regenerate NAD+

Regulation
Glc
G6P
F6P
F16BP
DHAP + G3P
1,3-BPG
3-PG
2-PG
PEP
Pyr
PK
HK
PFK-1
Epinephrine (cardiac muscle)
cAMP ATP
F26BP
PFK-2 (active) PFK-2 (inactive)
AC
PKA (active)
PKA (inactive)

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