contains outline and details of drug delivery systems of ocular drugs

1. OCULAR DRUG DELIVERY
SYSTEM
Presented by:-
G.V.Narasimha Rao
22PH203A04
Mpharm (Pharmaceutics)
Anurag University.

2. CONTENTS
Introduction
Anatomy and physiology of Eye
Mechanism of ocular Absorption
Ophthalmic Dosage form introduction and classification
Marketed ocular drug delivery products
Evaluation of OCDDS
Conclusion and outlook
References

3. INTRODUCTION
• Designed to treat ophthalmic diseases.
• Meant for local therapy and not for systemic action.
• Eye-easily accessible site for tropical administration.

4. Ideal characteristics of OCDDS
Sterility
Isotonicity
Ex:-1.9%boric acid and 0.9%NaCl
Buffer/pH adjustment
Less drainage tendency
Minimum protein binding

8. Ophthalmic Dosage Form
Ophthalmic preparations are sterile products (free from
foreign particles)that are intended to be applied topically to
cornea or instilled in the space between the eyeball and
lower eyelid.
The following dosage forms have been developed to
ophthalmic drugs.

10. Selected types of OCDDS
1.Aqueous eye drops 2.Oily eye drops
3.Eye
ointments
4.Eye lotions

11. 5.Paper strips 6.occuserts
7.Hydro gel contact lens 8.Collagen shields

12. Conventional Delivery Systems
EYE DROPS
Widely administered drugs as liquid dosage forms.
Only 5%of the dose is absorbed.
Mostly absorbed through systemic circulation.

13.  Ointment and gels
Prolongation of drug contact time.
Blurring of vision & matting of eyelids can limit its use.

14.  Ocuserts and Lacriserts
Sterile preparation.
C.R dosage forms.
Treatment of dry eye syndrome and keratitis sicca.

15. 2.Vesicular systems
• LIPOSOMES
Liposomes are bio compatible and bio degradable lipid vesicles made
up of natural lipids.
They include drugs with low partition coefficient ,poor solubility.

16. 3.Controlled delivery system
1. Implants
2. Iontophoresis
3. Microemulsion
4. Nano suspensions
5. Micro needle
6. Mucoadhesive polymers

17. 4.Particulate System(Nano and micro particles)
The maximum permissible size limit for microparticles is about 5-
10mm for ophthalmic administration.
Nanoparticles are prepared using bio adhesive polymers to provide
sustained effect to the entrapped drugs.
That is why microspheres and nanoparticles are promising drug
carriers for ophthalmic application.

19. EVALUATION OF OCDDS
1) Thickness of the film.
2) Content uniformity.
3) Uniformity of weight.
4) Percentage moisture absorption.
5) Percentage moisture loss.
6) Invitro and in vivo drug release.
7) Accelerated stability studies.

20. CONCLUSION
Ocular drug delivery systems provide local as well as
systemic delivery of drugs.
The novel advanced delivery systems offer more protective
and effective means of drug delivery

21. FUTURE OUTLOOK
The latest available targeted drug delivery systems focus on the
localised delivery of the drugs as well as certain macromolecular
substance like proteins , genes like DNA , siRNA to the internal parts
of the eye.
Further developments are preferable which will eliminate the
disadvantages of these available advanced delivery systems and will
male readily acceptable among the patients.