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Research on Breast Cancer
Made by
MS Fadi Saad
Diagram of the Breast
The breast is a glandular organ.
It is made up of a network of
mammary ducts.
Each breast has about 15-20
mammary ducts that lead to
lobes that are made up of
lobules.
The lobules contain cells that
secrete milk that are stimulated
by estrogen and progesterone
which are ovarian hormones.
Definition of Breast Cancer
BC is malignant(cancer) tumor that originating from
breast tissue, most commonly from the inner lining
of milk ducts or the lobules that supply the ducts
with milk. Cancers originating from ducts are known
as ductal carcinomas, while those originating from
lobules are known as lobular carcinomas. Breast
cancer occurs in humans and other mammals. While
the overwhelming majority of human cases occur in
women, male breast cancer can also occur.
History about BC in female
* The first case-controlled study on breast cancer epidemiology
was done by Janet Lane - Claypon , who published a comparative
study in 1926 of 500 breast cancer cases and 500 control patients
of the same background and lifestyle for the British Ministry of
Health.
• In the 1980s and 1990s, thousands of women who had
successfully completed standard treatment then demanded and
received high-dose bone marrow transplants, thinking this
would lead to better long-term survival. However, it proved
completely ineffective, and 15–20% of women died because of
the brutal treatment.
• Prominent women who died of breast cancer include Anne of
Austria, the mother of Louis XIV of France; Mary Washington,
mother of George, and Rachel Carson, the environmentalist.
Types of BC
There are many types of breast cancer, but some of
them are very rare, Sometimes a breast tumor can be
a mix of these types or a mixture of invasive and in
situ cancer:
 Ductal carcinoma in situ (DCIS)
 Invasive (or infiltrating) ductal
carcinoma (IDC)
 Invasive (infiltrating) lobular
carcinoma (ILC)
 Inflammatory breast cancer (IBC)
 Metastatic breast cancer
 Triple negative breast cancer
Signs & Symptoms
The most common symptom of breast cancer is a new lump or mass. A
lump that is painless, hard, and has uneven edges is more likely to be
cancer. But some cancers are tender, soft, and rounded or even painful.
So it's important to have anything new or unusual checked by a doctor.
Other symptoms of breast cancer include the following:
 Swelling of all or part of the breast
 Skin irritation or dimpling
 Breast pain
 Nipple pain or the nipple turning inward
 Redness, scaliness , or thickening of the nipple or breast skin
 A nipple discharge other than breast milk
Although these symptoms can be caused by things other than breast cancer, it is
important to have them checked out by doctor.
Symptoms
Diagnosis the BC (test diagnosis)
Mammograms
Clinical breast exam
Breast awareness and breast self-exam
MRI (magnetic resonance imaging)
Breast ultrasound
Biopsy
HER2/neu status
Tests of gene patterns
Risk Factor of BC
While we do not yet know exactly what causes breast cancer, we do know that certain
risk factors are linked to the disease, A risk factor is something that affects your
chance of getting a disease such as cancer.
Risk factors you cannot change
Gender
Age
Genetic risk factors
Family history
Personal history of breast
cancer:
Race
Dense breast tissue
Certain benign (not
cancer) breast problems
Breast radiation early in
life
Menstrual periods
Lobular carcinoma in situ
Risk of Factor of BC
Risk and lifestyle choices
 Not having children or having them later in life
 Certain kinds of birth control
 Using hormone therapy after menopause
 Not breastfeeding
 Alcohol
 Being overweight or obese
The percentage of infection
TNM Staging System
• size (T stands for tumor)
• lymph node involvement (N stands for node)
• whether the cancer has
metastasized (M stands for metastasis), or
moved beyond the breast to other parts of the
body.
Treatment & Medication
The main types of treatment for breast cancer are:
 Surgery
Radiation
Chemotherapy
Hormone therapy
Drugs
Epidemiology
• Breast cancer is related to age with only 5% of all breast cancers
occur in women under 40 years old.
• In the twelve world regions, the annual age-standardized incidence
rates per 100,000 women are as follows:
 Eastern Asia – 18 per 100,000 women
 South Central Asia - 22 per 100,000 women
 Sub-Saharan Africa – 22 per 100,000 women
 South-Eastern Asia – 26 per 100,000 women
 North Africa - 28 per 100,000 women
 Western Asia - 28 per 100,000 women
 South and Central America - 42 per 100,000 women
 Eastern Europe - 49 per 100,000 women
 Southern Europe - 56 per 100,000 women
 Northern Europe - 73 per 100,000 women
References
Wikipedia.com
National Cancer institute.com
WebMD.com
Mayoclinic.com
American Cancer Society
Breast health center
Thanks for your Attention

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Presentation on breast cancer

  • 1. Research on Breast Cancer Made by MS Fadi Saad
  • 2. Diagram of the Breast The breast is a glandular organ. It is made up of a network of mammary ducts. Each breast has about 15-20 mammary ducts that lead to lobes that are made up of lobules. The lobules contain cells that secrete milk that are stimulated by estrogen and progesterone which are ovarian hormones.
  • 3. Definition of Breast Cancer BC is malignant(cancer) tumor that originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. Cancers originating from ducts are known as ductal carcinomas, while those originating from lobules are known as lobular carcinomas. Breast cancer occurs in humans and other mammals. While the overwhelming majority of human cases occur in women, male breast cancer can also occur.
  • 4. History about BC in female * The first case-controlled study on breast cancer epidemiology was done by Janet Lane - Claypon , who published a comparative study in 1926 of 500 breast cancer cases and 500 control patients of the same background and lifestyle for the British Ministry of Health. • In the 1980s and 1990s, thousands of women who had successfully completed standard treatment then demanded and received high-dose bone marrow transplants, thinking this would lead to better long-term survival. However, it proved completely ineffective, and 15–20% of women died because of the brutal treatment. • Prominent women who died of breast cancer include Anne of Austria, the mother of Louis XIV of France; Mary Washington, mother of George, and Rachel Carson, the environmentalist.
  • 5. Types of BC There are many types of breast cancer, but some of them are very rare, Sometimes a breast tumor can be a mix of these types or a mixture of invasive and in situ cancer:  Ductal carcinoma in situ (DCIS)  Invasive (or infiltrating) ductal carcinoma (IDC)  Invasive (infiltrating) lobular carcinoma (ILC)  Inflammatory breast cancer (IBC)  Metastatic breast cancer  Triple negative breast cancer
  • 6. Signs & Symptoms The most common symptom of breast cancer is a new lump or mass. A lump that is painless, hard, and has uneven edges is more likely to be cancer. But some cancers are tender, soft, and rounded or even painful. So it's important to have anything new or unusual checked by a doctor. Other symptoms of breast cancer include the following:  Swelling of all or part of the breast  Skin irritation or dimpling  Breast pain  Nipple pain or the nipple turning inward  Redness, scaliness , or thickening of the nipple or breast skin  A nipple discharge other than breast milk Although these symptoms can be caused by things other than breast cancer, it is important to have them checked out by doctor.
  • 8. Diagnosis the BC (test diagnosis) Mammograms Clinical breast exam Breast awareness and breast self-exam MRI (magnetic resonance imaging) Breast ultrasound Biopsy HER2/neu status Tests of gene patterns
  • 9. Risk Factor of BC While we do not yet know exactly what causes breast cancer, we do know that certain risk factors are linked to the disease, A risk factor is something that affects your chance of getting a disease such as cancer. Risk factors you cannot change Gender Age Genetic risk factors Family history Personal history of breast cancer: Race Dense breast tissue Certain benign (not cancer) breast problems Breast radiation early in life Menstrual periods Lobular carcinoma in situ
  • 10. Risk of Factor of BC Risk and lifestyle choices  Not having children or having them later in life  Certain kinds of birth control  Using hormone therapy after menopause  Not breastfeeding  Alcohol  Being overweight or obese
  • 11. The percentage of infection
  • 12. TNM Staging System • size (T stands for tumor) • lymph node involvement (N stands for node) • whether the cancer has metastasized (M stands for metastasis), or moved beyond the breast to other parts of the body.
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  • 14. Treatment & Medication The main types of treatment for breast cancer are:  Surgery Radiation Chemotherapy Hormone therapy Drugs
  • 15. Epidemiology • Breast cancer is related to age with only 5% of all breast cancers occur in women under 40 years old. • In the twelve world regions, the annual age-standardized incidence rates per 100,000 women are as follows:  Eastern Asia – 18 per 100,000 women  South Central Asia - 22 per 100,000 women  Sub-Saharan Africa – 22 per 100,000 women  South-Eastern Asia – 26 per 100,000 women  North Africa - 28 per 100,000 women  Western Asia - 28 per 100,000 women  South and Central America - 42 per 100,000 women  Eastern Europe - 49 per 100,000 women  Southern Europe - 56 per 100,000 women  Northern Europe - 73 per 100,000 women
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  • 18. Thanks for your Attention