2. Diagram of the Breast
The breast is a glandular organ.
It is made up of a network of
mammary ducts.
Each breast has about 15-20
mammary ducts that lead to
lobes that are made up of
lobules.
The lobules contain cells that
secrete milk that are stimulated
by estrogen and progesterone
which are ovarian hormones.
3. Definition of Breast Cancer
BC is malignant(cancer) tumor that originating from
breast tissue, most commonly from the inner lining
of milk ducts or the lobules that supply the ducts
with milk. Cancers originating from ducts are known
as ductal carcinomas, while those originating from
lobules are known as lobular carcinomas. Breast
cancer occurs in humans and other mammals. While
the overwhelming majority of human cases occur in
women, male breast cancer can also occur.
4. History about BC in female
* The first case-controlled study on breast cancer epidemiology
was done by Janet Lane - Claypon , who published a comparative
study in 1926 of 500 breast cancer cases and 500 control patients
of the same background and lifestyle for the British Ministry of
Health.
• In the 1980s and 1990s, thousands of women who had
successfully completed standard treatment then demanded and
received high-dose bone marrow transplants, thinking this
would lead to better long-term survival. However, it proved
completely ineffective, and 15–20% of women died because of
the brutal treatment.
• Prominent women who died of breast cancer include Anne of
Austria, the mother of Louis XIV of France; Mary Washington,
mother of George, and Rachel Carson, the environmentalist.
5. Types of BC
There are many types of breast cancer, but some of
them are very rare, Sometimes a breast tumor can be
a mix of these types or a mixture of invasive and in
situ cancer:
Ductal carcinoma in situ (DCIS)
Invasive (or infiltrating) ductal
carcinoma (IDC)
Invasive (infiltrating) lobular
carcinoma (ILC)
Inflammatory breast cancer (IBC)
Metastatic breast cancer
Triple negative breast cancer
6. Signs & Symptoms
The most common symptom of breast cancer is a new lump or mass. A
lump that is painless, hard, and has uneven edges is more likely to be
cancer. But some cancers are tender, soft, and rounded or even painful.
So it's important to have anything new or unusual checked by a doctor.
Other symptoms of breast cancer include the following:
Swelling of all or part of the breast
Skin irritation or dimpling
Breast pain
Nipple pain or the nipple turning inward
Redness, scaliness , or thickening of the nipple or breast skin
A nipple discharge other than breast milk
Although these symptoms can be caused by things other than breast cancer, it is
important to have them checked out by doctor.
8. Diagnosis the BC (test diagnosis)
Mammograms
Clinical breast exam
Breast awareness and breast self-exam
MRI (magnetic resonance imaging)
Breast ultrasound
Biopsy
HER2/neu status
Tests of gene patterns
9. Risk Factor of BC
While we do not yet know exactly what causes breast cancer, we do know that certain
risk factors are linked to the disease, A risk factor is something that affects your
chance of getting a disease such as cancer.
Risk factors you cannot change
Gender
Age
Genetic risk factors
Family history
Personal history of breast
cancer:
Race
Dense breast tissue
Certain benign (not
cancer) breast problems
Breast radiation early in
life
Menstrual periods
Lobular carcinoma in situ
10. Risk of Factor of BC
Risk and lifestyle choices
Not having children or having them later in life
Certain kinds of birth control
Using hormone therapy after menopause
Not breastfeeding
Alcohol
Being overweight or obese
12. TNM Staging System
• size (T stands for tumor)
• lymph node involvement (N stands for node)
• whether the cancer has
metastasized (M stands for metastasis), or
moved beyond the breast to other parts of the
body.
13.
14. Treatment & Medication
The main types of treatment for breast cancer are:
Surgery
Radiation
Chemotherapy
Hormone therapy
Drugs
15. Epidemiology
• Breast cancer is related to age with only 5% of all breast cancers
occur in women under 40 years old.
• In the twelve world regions, the annual age-standardized incidence
rates per 100,000 women are as follows:
Eastern Asia – 18 per 100,000 women
South Central Asia - 22 per 100,000 women
Sub-Saharan Africa – 22 per 100,000 women
South-Eastern Asia – 26 per 100,000 women
North Africa - 28 per 100,000 women
Western Asia - 28 per 100,000 women
South and Central America - 42 per 100,000 women
Eastern Europe - 49 per 100,000 women
Southern Europe - 56 per 100,000 women
Northern Europe - 73 per 100,000 women