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2007 roma, campus biomedico, università di ingegnieria. quale raporto tra bioingegniere e medico
1. Quale rapporto tra
bioingegniere e medico ?
Stefano Nardi, MD, PhD
AZIENDA OSPEDALIERA SANTA MARIA, TERNI
DIPARTIMENTO CARDIOTORACOVASCOLARE
STRUTTURA COMPLESSA DI CARDIOLOGIA
CENTRO DI ARITMOLOGIA CLINICA ED
ELETTROFISIOLOGIA CARDIACA
LABORATORIO DI ELETTROFISIOLOGIA ED ELETTROSTIMOLAZIONE
3. Cell-Membrane Resting Potential
+
-
0 mV
….a “resting” potential of -90 mV is
observed inside the cell with respect to
outside the cell
Advance needle electrode
across the cell membrane….
4. Cell-Membrane Resting Potential
+
The resting potential is maintained by an ATP
powered sodium-potassium “pump” within the
membrane that transports Na+
ions outward
and K+
ions inward (3 Na+
per 2 K+
).
Na+
K+ Na+
Na+
The gradient of ion-concentration separates
charge across the membrane with an equal and
opposite electrical gradient of -90 mV.
-
K+
Advance needle electrode
across the cell membrane….
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-- -
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+
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5. Cell Membrane Action Potential (AP)
+
-
Stimulate the cell….
0 mV
….a transmembrane “AP” is observed
with 5 characteristic phases (Φ)
19. • Surface-based
– 5.6 kHz current signal emitted from 3 pairs of surface electrodes
–Each catheter electrode located 93 times per second
– Visualize all catheters in 3D space for cardiac navigation
Virtual Reality Methodology
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Accesso dalla vena femorale.
HRA = registra l’impulso così come si genera dal nodo SA
HBE = Registrazione del fascio di His. Non acquisisce il segnale dal nodo AV, ma lo acquisisce subito sotto sul fascio di His (vicino la tricuspide). Questo rivela all’elettrofisiologo quanto tempo impiega l’impulso per passare dal nodo SA al nodo AV.
RVA = segnale dal ventricolo destro
Coronary Sinus = riceve il segnale da LA e LV.
Any type of catheter (electrode based)
Up to 12 catheters, 64 electrodes
EnSite NavX enables physicians to visualize and navigate a myriad of intracardiac catheters in any chamber of the heart. It also simultaneously displays more electrodes and catheters than any other 3-D mapping system currently available.
EnSite NavX is compatible with catheters from all manufacturers. The non-proprietary nature of our technology gives you freedom of choice for diagnostic and ablation catheters.
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AVI movie
Here’s a quick illustration to show you how the chamber maps are built. At the start of an EnSite procedure, the catheter is inserted in the chamber and validated by the system.
(click on map image)
As a catheter is moved within the chamber, the system records three-dimensional points. The operator can also give certain points special emphasis (indicated by white squares)—these are called locked points, to help define key areas of the anatomy, such as the isthmus or crista. As seen in the published literature, chamber maps or geometries can be built in as little as five minutes. Thereafter, there is no need for fluoroscopy, since the system provides superior orientation to fluoroscopy through the 3D model and superior catheter orientation through the 3D catheter display.
When the geometry is finished, event data can then be recorded.
(SLIDE 5) At this purpose nowadays, novel and different technologies for mapping, tracking and ablation are available for approaching AF and in this view the technologic progress continuous to evolving over the time.
In this example we will be segmenting a left atrium
Subregioning crops away information that is not pertinent to the segmentation
Segmentation in EnSite Verismo is a point-and-click interface. Select a tool for a specific task, click in the slice views to create a 3D model in the fourth panel.
Controls in the panel views allow navigation to any slice in the model in each direction. The 2D views also feature zoom, pan, and window/level (brightness and contrast) adjustments.
The first tool is Region Grow. Region Grow is used to quickly create the majority of the model. Subsequent tools will refine the model.
In Region Grow, the user defines an area of interest by placing a “seed point” in a structure, in this example, the left atrium. After placing the seed, the user will adjust the min and max threshold using the sliders; thresholding defines what intensity of greyscale values (light vs dark) will be used to create the model. The area of the model covered by the current threshold setting is colored translucent red. Boundary emphasis identifies sharp transitions in intensity; those areas are colored grey.
The effect of these controls:
The seed point identifies where the algorithm should search for connected intensities.
Thresholding controls how well the model is filled in.
Boundary emphasis identifies the edges between structures, important for the following step
Correlating edges of the model appear as lines in the slice views
Note that the created model includes partial models of the RA, RV, and LV. The partial creation of these structures is relative to their distance from the point that we placed during region grow, and the relative contrast and connection of the blood pool.
The 3D model can be rotated, zoomed, and panned
The worldview torso will rotate with the model
Clicking the buttons at the top of the screen will access familiar angles
The current model includes all of the data we need, and more
The list controls which structure is currently being segmented.
Here is the model as it appears with separated structures. If a break between structures is not at the desired location, the separator tool can be repeated on the structures in question.
To review the LA, simply disable the display of the other structures in the list.
Optionally, manual segmentation tools can be used to trim away extraneous information.
In the final step, Verismo converts the solid model of the blood pool to a tiled surface comprised of thousands of triangles. This model is similar to the geometries on the EnSite System and allows the use of familiar clinical functions such as translucency, clipping, and labeling.
The completed model may be saved to the system hard drive or exported to CD.
Distal PV branches can serve as useful spatial landmarks, and can be readily delineated by the placement of 3D spherical markers during catheter pullback.