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ECRD.IN
LATE PROF NILAY CHOUDHARY MEMORIAL LECTURE
21.12.2013
DR.AMITA ATHAVALE
PROFESSOR & HEAD
DEPT.OF CHEST MEDICINE & ENVIRONMENTAL POLLUTION RESEARCH
CENTRE,KEM HOSPITAL & SETH G.S.MEDICAL
COLLEGE,PAREL,MUMBAI,INDIA.
ECRD.IN
Lungs:largest surface area
Intake of “Air”-10 times Food
Every misery has it’s cry ….
….Health remains silent
When You Can’t Breathe,
Nothing Else Matters
ECRD.IN
IRRITATION INFLAMMATION
ASPHYXIATION DESTRUCTION
MUTATION
ECRD.IN
1954 LONDON
BHOPAL 1984
2009 DELHI DEATH
TOLL?
A SILENT
KILLER
MUMBAI 2005
ECRD.IN
WORK HOME
23 hours indoors: home or work, transit
US EPA ranked American home 4th in list of serious health hazard
CHANGING CLIMATE…
CHANGING ENVIRONMENT
ECRD.IN
Do you feel sick in office or home
environment ?
• ETS
• Dust mites- 1 mcg – 10 mcg
• Mould- visible mould damage,odour
• Radon- 200-400bq/m3
• VOC’S
• Asbestos
• Man made mineral fibers
• SPM
• CO2
• SICK BUILDING SYNDROME
ECRD.IN
Melting Glaciers…
Rising Temperature
Changing Lifestyles
Dampness Dust HVAC
ECRD.IN
ECRD.IN
Source apportionment
ECRD.IN
SPM LEVELS-2002-2011
0
200
400
600
800
1000
1200
1400
Worli
Khar
Andheri
Bhandup
Borivali
marvali
Deonar
SPM LEVELS-2002-2011
AQMRL (CRITERIA POLLUTANTS)
MUNICIPAL CORPORATION OF GREATER MUMBAI
ECRD.IN
CENSUS BY SOCIAL
WORKER & HEALTH VISITOR
QUESTIONNAIRE FILLING
CLINICAL EXAMINATION PORTABLE LUNG FUNCTION
S
T
U
D
Y
M
E
T
H
O
D
O
L
O
G
Y
ECRD.IN
Equipment Used
Personal
monitor Indoor particulate monitorPortable lung function
PULMONARY FUNCTION TESTING LAB
Chest Medicine & EPRC
ECRD.IN
Profile of Diagnosis - MoEF
Normal
Bronchitis
Eosino
Other chest
Cardiac
URTI
Asthma
General diseases
Allergic rhintis
OAD
Diagnosis
Pies show counts
Normal
56.92%
Bronchitis
3.56%
Eosino
0.11%
Other chest
2.63%Cardiac
2.35%URTI
2.57%
Asthma
4.16%
General diseases
10.29%
Allergic rhintis
5.69%
OAD
11.71%
DIAGNOSIS
ECRD.IN
Why study asthma air pollution link?
ENVIRONMENT
INDOOR
OUTDOOR
A
s
th
m
a
GENETICS
ECRD.IN
Peak morning traffic ……decreased by 23%
Peak ozone levels ………..decreased by 28%
Emergency room visits for Asthma ………decreased by …..42%
ECRD.IN
ASTHMA PREVALENCE SCHOOL
CHILDREN 3947
ECRD.IN
Chafa flower Pollen grain
Drum stick flower Pollen grain
ECRD.IN
August 2005
2
1
2 2 2
3
6
1
9
3
2 2
11
2
6
4
7
4
5
11
4
2
0
1
2
3
4
5
6
7
8
9
JAN
FEB
M
A
R
A
PR
M
A
Y
JUN
JUL
A
U
G
SEPT
O
C
T
N
O
V
D
EC
ASTHMA ADMISSIONS
2001
2005
n=39
n=34
ECRD.IN
ILD
?Nox ?RSPM
Pigeons
Hypersensitivity
pneumonitis
Genetics
Hypersensitivity
pneumonitis
Incidence of ILD
Year Total
No. of
New
Cases
ILD %
2000 1479 62 4.1%
2010 1871 95 5.1%
ECRD.IN
March 2012
• Ghatkopar residents say pigeons
are killing them
• Say several of them have
contracted respiratory diseases
due to allergens in the bird
droppings and feathers. Doctor
says four residents have died so
far due to the disease and 12
others have been diagnosed with
it; local Kabutar Khana blamed
ECRD.IN
ORGANIC DUST
ECRD.IN
Problems reported by citizens
Gorai Dumping ground
Normal
Bronchitis
TB
Others
Cardiac
URTI
Asthma
General
All.rhinitis
ECRD.IN
ECRD.IN
Gorai Dumping Ground Survey
Following concerns raised by the residents of BSES Society and Navlai Society,Gorai a questionnaire survey was
conducted by EPRC, K.E.M Hospital between 7/9/2011 to 28/9/2011.
Gautam Nagar – Deonar
Following the complaint from residents of Gautam Nagar, Opp. Deonar Police Station, Govandi, visit to
area was undertaken on 18-11-2011. This was followed by census and questionnaire survey from
EPRC, K.E.M. Hospital from 23/11/2011 to 25/11/2011.
In the population surveyed 7.6% complained of cough, 17% complained of breathlessness 16% had complained of eye irritation
and 34.9% had complained frequent sneezing. Considering the problem reported by the citizens exposure to cement dust, the
respiratory morbidity observed in this area is significant.
In the population studied 14.5%
complained breathlessness 13.7% had
complained eye irritation and 31.5%
frequent sneezing considering the
problem reported by the citizen regarding
exposure to cement dust, respiratory
morbidity observed in this area is
significant.
ECRD.IN
ECRD.IN
May 2007-
Wadala (Mumbai)
• Respiratory
morbidity
reported
significant
• Studied lung
functions
comparable to
control area.
ECRD.IN
To Determine the health effects of the different
modes of travel to place of work
ECRD.IN
Impact of COPD in India
ECRD.IN
Study of the long term effect of
Indoor biomass smoke on lung
Exposure to long term biomass smoke
is associated with structural and functional
changes in lung.
ECRD.IN
Occupation related
Traffic police survey
Obstructive
Restricitve
Mixed
SAO
Normal
Obstructive
Restricitve
Mixed
SAO
Normal
PFT in traffic police in Smokers PFT in traffic police in non-smokers
ECRD.IN
Occupation related
Incidence of Silicosis in Flour mill workers
30.4% flour mill workers had Silicosis
ECRD.IN
34 yrs GARDENER, WATERED PLANTS
WITH TREATED WASTEWATER
ECRD.IN
THERAPEUTIC BAL UNDER GA
ECRD.IN
• 52/M
• Non-smoker
• Worked in a bakery for > 30 years
• C/O
• Productive cough and exertional
breathlessness since 2 years
• Treated with AKT on multiple occassions
due to Xray changes with no relief
• No h/o HT/DM/IHD
ECRD.IN
Radiology: PMF
ECRD.IN
NEEDLE SHAPED (SILICA) BIREFRINGENT
CRYSTALS IN SAMOSA PATTI
(Polarising microscopy)
DEPT. OF PATHOLOGY, K.E.M. HOSPITAL
ECRD.IN
Gold Polishing Industry
Bhuleshwar area
ECRD.IN
8
6
7.4
12
1.71.7
4.3
0.9
0
2
4
6
8
10
12
14
Bronchitis
A
sthm
a
U
R
TI
O
therC
hestD
iseases
%AGE
Bhuleswar Kalbadevi
n=149 n=116
ECRD.IN
Urban outdoor air pollution is estimated to cause 1.3 million
deaths worldwide per year. Those living in middle-income
countries disproportionately experience this burden.
…. Air Quality and Health, WHO Fact Sheet NO -313, Sept. 2011
Deaths and DALYs attributable to five environmental risks,
and to all five risks combined by region, 2004
Source : Global Health Risks, WHO, 2009
India Falls under Low and Middle Income Category
ECRD.IN
Carcinogenic potential of PAHs is estimated with equivalent of
Benzo (a) pyrene. On the basis of BaPE calculation, residential
site has the maximum values of 18.8 and 13.6 for ambient and
indoor sampling location respectively.
Colaba Dadar Khar Mahul
BaPE Out 3.5 3.8 18.8 7.9
In 6.4 9.7 13.6 4.5
Lung Cancer Cases
/Yr.
Predicted
(2007)
1 3 16 8
Actual (2007) 8 7 10 13
Sum of PAHs
Identified ng/m3
Out 35.7 42.96 175.7
6
90.78
In 75.10 79.28 134.1
8
46.94
Carcinogenic Potential of PAHs-Mumbai City
SOURCE:NEERI MUMBAI
ECRD.IN
Conclusions
INDOORS
 Ratio at control sites (>1) indicates that there is a strong indoor
source for fine particles. At kerbsite I/0 ratio was 1.02 ± 0.14, close
to 1 indicating equal indoor and outdoor levels.
 Theoretical I/O ratio and RCS model supports that indoor air
particles are derived from outdoor air at kerb and residential sites.
 Highest BaPE was also observed at residential site indoors.
Though I/O ratio is less than one at residential site toxic pollution
characteristics of fine particles is greater. High indoor toxic
pollution affects personal exposure.
 Control systems are primarily:
 Creation of Ventilation Systems
 AC premises: proper HVAC system
 Indoor material selections
ECRD.IN
Indoor
Air
Indoor air affects
vulnerable
population as they
spend maximum
time indoors.
Controlling indoor
air pollution will
help to achieve
millennium
development goal
4 and 5 related to
mortality and
morbidity of
women and
children.
 Use of clean fuel like LPG
 Ventilation standards and building codes for
Indian condition
 Adoption of Leadership in Energy &
Environmental Design (LEED) Standards for
indoor air improvement in residential and
commercial places.
 Indoor air quality surveillance by corporation
and pollution control boards at regular
interval/on request due to health effects
 Manufacturing standards for Indoor air
quality products eg paints, cleaners etc.
Recommendations
ECRD.IN
ENVIRONMENTAL PROBLEMS
45.1
52.2
41.6
38.4
28.2
56.6
38.9
0
10
20
30
40
50
60
70
80
90
100
Vehicular Pollution Vehicle Noise
Pollution
Solid Waste
Pollution
Ground Water
Pollution
Rain Water Pollution Indoor Pollution Industrial Pollution
ENVIRONMENT
People’s perception of
environmental problems
ECRD.IN
4522.96 million Rupees…..50
microgram rise particulates
• Monetary burden of health impacts of air
pollution in Mumbai, India
• Public Health. 2011 Mar;125(3):157-64.
• Monetary burden of health impacts of air
pollution in Mumbai, India: Implications for
public health policy.
• Patankar AM, Trivedi PL. K.J. Somaiya Institute
of Management Studies and Research,
Vidyavihar (East), Mumbai 400077, India.
ECRD.IN
APRIL 2004 SARS
APRIL 2009
NOVEL FLU
PANDEMIC
ECRD.IN
Vector borne diseases & Lung
• P. Vivax malaria – Thrombocytopenia , acute
lung injury, ARDS
• Dengue- ARDS
• Leptospirosis Water scarcity
Construction
Water logging
ECRD.IN
Survival of the fittest
• Susceptible population at greatest risk
Genetically susceptible
Geographically susceptible
? Economically susceptible
ECRD.INPRANAYAM
ECRD.IN
DIET IN HEALTH & DISEASE
ECRD.IN
Environ Health Perspect. 2008 November; 116(11): A478–A485.
PMCID: PMC2592293
Linking TB and the Environment: An Overlooked Mitigation
Strategy
Charles W. Schmidt
“But doing that won’t be easy. Social and environmental interventions aren’t usually
delivered or funded by the health sector, so that means we all have to work with
other sectors, in particular housing, energy, and education, to
move them forward.”
TB control strategies adopted by the WHO and other organizations emphasize clinical
solutions in the form of drugs, vaccines, and access to health care. But despite the
success of these programs, TB incidence and mortality aren’t falling rapidly enough to
meet WHO targets, and in some areas, particularly in parts of Asia and throughout sub-
Saharan Africa, they continue to climb
“Better treatment is essential, but if we want to affect longer-term trends in the
epidemic we will also have to deal with risk factors,” asserts Eva Rehfuess, a scientist
with the WHO Department of Public Health and Environment
ECRD.IN
SCIENTIFIC EVIDENCE CAN BOLSTER
CONTROVERSIAL POLICY DECISIONS?
FLYOVERS
SKYWALKS
ECRD.IN
“Those who contemplate the beauty of the
earth find reserves of strength that will
endure as long as life lasts.”

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Air Pollution on Human Health

  • 1. ECRD.IN LATE PROF NILAY CHOUDHARY MEMORIAL LECTURE 21.12.2013 DR.AMITA ATHAVALE PROFESSOR & HEAD DEPT.OF CHEST MEDICINE & ENVIRONMENTAL POLLUTION RESEARCH CENTRE,KEM HOSPITAL & SETH G.S.MEDICAL COLLEGE,PAREL,MUMBAI,INDIA.
  • 2. ECRD.IN Lungs:largest surface area Intake of “Air”-10 times Food Every misery has it’s cry …. ….Health remains silent When You Can’t Breathe, Nothing Else Matters
  • 4. ECRD.IN 1954 LONDON BHOPAL 1984 2009 DELHI DEATH TOLL? A SILENT KILLER MUMBAI 2005
  • 5. ECRD.IN WORK HOME 23 hours indoors: home or work, transit US EPA ranked American home 4th in list of serious health hazard CHANGING CLIMATE… CHANGING ENVIRONMENT
  • 6. ECRD.IN Do you feel sick in office or home environment ? • ETS • Dust mites- 1 mcg – 10 mcg • Mould- visible mould damage,odour • Radon- 200-400bq/m3 • VOC’S • Asbestos • Man made mineral fibers • SPM • CO2 • SICK BUILDING SYNDROME
  • 11. ECRD.IN CENSUS BY SOCIAL WORKER & HEALTH VISITOR QUESTIONNAIRE FILLING CLINICAL EXAMINATION PORTABLE LUNG FUNCTION S T U D Y M E T H O D O L O G Y
  • 12. ECRD.IN Equipment Used Personal monitor Indoor particulate monitorPortable lung function PULMONARY FUNCTION TESTING LAB Chest Medicine & EPRC
  • 13. ECRD.IN Profile of Diagnosis - MoEF Normal Bronchitis Eosino Other chest Cardiac URTI Asthma General diseases Allergic rhintis OAD Diagnosis Pies show counts Normal 56.92% Bronchitis 3.56% Eosino 0.11% Other chest 2.63%Cardiac 2.35%URTI 2.57% Asthma 4.16% General diseases 10.29% Allergic rhintis 5.69% OAD 11.71% DIAGNOSIS
  • 14. ECRD.IN Why study asthma air pollution link? ENVIRONMENT INDOOR OUTDOOR A s th m a GENETICS
  • 15. ECRD.IN Peak morning traffic ……decreased by 23% Peak ozone levels ………..decreased by 28% Emergency room visits for Asthma ………decreased by …..42%
  • 17. ECRD.IN Chafa flower Pollen grain Drum stick flower Pollen grain
  • 18. ECRD.IN August 2005 2 1 2 2 2 3 6 1 9 3 2 2 11 2 6 4 7 4 5 11 4 2 0 1 2 3 4 5 6 7 8 9 JAN FEB M A R A PR M A Y JUN JUL A U G SEPT O C T N O V D EC ASTHMA ADMISSIONS 2001 2005 n=39 n=34
  • 19. ECRD.IN ILD ?Nox ?RSPM Pigeons Hypersensitivity pneumonitis Genetics Hypersensitivity pneumonitis Incidence of ILD Year Total No. of New Cases ILD % 2000 1479 62 4.1% 2010 1871 95 5.1%
  • 20. ECRD.IN March 2012 • Ghatkopar residents say pigeons are killing them • Say several of them have contracted respiratory diseases due to allergens in the bird droppings and feathers. Doctor says four residents have died so far due to the disease and 12 others have been diagnosed with it; local Kabutar Khana blamed
  • 22. ECRD.IN Problems reported by citizens Gorai Dumping ground Normal Bronchitis TB Others Cardiac URTI Asthma General All.rhinitis
  • 24. ECRD.IN Gorai Dumping Ground Survey Following concerns raised by the residents of BSES Society and Navlai Society,Gorai a questionnaire survey was conducted by EPRC, K.E.M Hospital between 7/9/2011 to 28/9/2011. Gautam Nagar – Deonar Following the complaint from residents of Gautam Nagar, Opp. Deonar Police Station, Govandi, visit to area was undertaken on 18-11-2011. This was followed by census and questionnaire survey from EPRC, K.E.M. Hospital from 23/11/2011 to 25/11/2011. In the population surveyed 7.6% complained of cough, 17% complained of breathlessness 16% had complained of eye irritation and 34.9% had complained frequent sneezing. Considering the problem reported by the citizens exposure to cement dust, the respiratory morbidity observed in this area is significant. In the population studied 14.5% complained breathlessness 13.7% had complained eye irritation and 31.5% frequent sneezing considering the problem reported by the citizen regarding exposure to cement dust, respiratory morbidity observed in this area is significant.
  • 26. ECRD.IN May 2007- Wadala (Mumbai) • Respiratory morbidity reported significant • Studied lung functions comparable to control area.
  • 27. ECRD.IN To Determine the health effects of the different modes of travel to place of work
  • 29. ECRD.IN Study of the long term effect of Indoor biomass smoke on lung Exposure to long term biomass smoke is associated with structural and functional changes in lung.
  • 30. ECRD.IN Occupation related Traffic police survey Obstructive Restricitve Mixed SAO Normal Obstructive Restricitve Mixed SAO Normal PFT in traffic police in Smokers PFT in traffic police in non-smokers
  • 31. ECRD.IN Occupation related Incidence of Silicosis in Flour mill workers 30.4% flour mill workers had Silicosis
  • 32. ECRD.IN 34 yrs GARDENER, WATERED PLANTS WITH TREATED WASTEWATER
  • 34. ECRD.IN • 52/M • Non-smoker • Worked in a bakery for > 30 years • C/O • Productive cough and exertional breathlessness since 2 years • Treated with AKT on multiple occassions due to Xray changes with no relief • No h/o HT/DM/IHD
  • 36. ECRD.IN NEEDLE SHAPED (SILICA) BIREFRINGENT CRYSTALS IN SAMOSA PATTI (Polarising microscopy) DEPT. OF PATHOLOGY, K.E.M. HOSPITAL
  • 39. ECRD.IN Urban outdoor air pollution is estimated to cause 1.3 million deaths worldwide per year. Those living in middle-income countries disproportionately experience this burden. …. Air Quality and Health, WHO Fact Sheet NO -313, Sept. 2011 Deaths and DALYs attributable to five environmental risks, and to all five risks combined by region, 2004 Source : Global Health Risks, WHO, 2009 India Falls under Low and Middle Income Category
  • 40. ECRD.IN Carcinogenic potential of PAHs is estimated with equivalent of Benzo (a) pyrene. On the basis of BaPE calculation, residential site has the maximum values of 18.8 and 13.6 for ambient and indoor sampling location respectively. Colaba Dadar Khar Mahul BaPE Out 3.5 3.8 18.8 7.9 In 6.4 9.7 13.6 4.5 Lung Cancer Cases /Yr. Predicted (2007) 1 3 16 8 Actual (2007) 8 7 10 13 Sum of PAHs Identified ng/m3 Out 35.7 42.96 175.7 6 90.78 In 75.10 79.28 134.1 8 46.94 Carcinogenic Potential of PAHs-Mumbai City SOURCE:NEERI MUMBAI
  • 41. ECRD.IN Conclusions INDOORS  Ratio at control sites (>1) indicates that there is a strong indoor source for fine particles. At kerbsite I/0 ratio was 1.02 ± 0.14, close to 1 indicating equal indoor and outdoor levels.  Theoretical I/O ratio and RCS model supports that indoor air particles are derived from outdoor air at kerb and residential sites.  Highest BaPE was also observed at residential site indoors. Though I/O ratio is less than one at residential site toxic pollution characteristics of fine particles is greater. High indoor toxic pollution affects personal exposure.  Control systems are primarily:  Creation of Ventilation Systems  AC premises: proper HVAC system  Indoor material selections
  • 42. ECRD.IN Indoor Air Indoor air affects vulnerable population as they spend maximum time indoors. Controlling indoor air pollution will help to achieve millennium development goal 4 and 5 related to mortality and morbidity of women and children.  Use of clean fuel like LPG  Ventilation standards and building codes for Indian condition  Adoption of Leadership in Energy & Environmental Design (LEED) Standards for indoor air improvement in residential and commercial places.  Indoor air quality surveillance by corporation and pollution control boards at regular interval/on request due to health effects  Manufacturing standards for Indoor air quality products eg paints, cleaners etc. Recommendations
  • 43. ECRD.IN ENVIRONMENTAL PROBLEMS 45.1 52.2 41.6 38.4 28.2 56.6 38.9 0 10 20 30 40 50 60 70 80 90 100 Vehicular Pollution Vehicle Noise Pollution Solid Waste Pollution Ground Water Pollution Rain Water Pollution Indoor Pollution Industrial Pollution ENVIRONMENT People’s perception of environmental problems
  • 44. ECRD.IN 4522.96 million Rupees…..50 microgram rise particulates • Monetary burden of health impacts of air pollution in Mumbai, India • Public Health. 2011 Mar;125(3):157-64. • Monetary burden of health impacts of air pollution in Mumbai, India: Implications for public health policy. • Patankar AM, Trivedi PL. K.J. Somaiya Institute of Management Studies and Research, Vidyavihar (East), Mumbai 400077, India.
  • 45. ECRD.IN APRIL 2004 SARS APRIL 2009 NOVEL FLU PANDEMIC
  • 46. ECRD.IN Vector borne diseases & Lung • P. Vivax malaria – Thrombocytopenia , acute lung injury, ARDS • Dengue- ARDS • Leptospirosis Water scarcity Construction Water logging
  • 47. ECRD.IN Survival of the fittest • Susceptible population at greatest risk Genetically susceptible Geographically susceptible ? Economically susceptible
  • 50. ECRD.IN Environ Health Perspect. 2008 November; 116(11): A478–A485. PMCID: PMC2592293 Linking TB and the Environment: An Overlooked Mitigation Strategy Charles W. Schmidt “But doing that won’t be easy. Social and environmental interventions aren’t usually delivered or funded by the health sector, so that means we all have to work with other sectors, in particular housing, energy, and education, to move them forward.” TB control strategies adopted by the WHO and other organizations emphasize clinical solutions in the form of drugs, vaccines, and access to health care. But despite the success of these programs, TB incidence and mortality aren’t falling rapidly enough to meet WHO targets, and in some areas, particularly in parts of Asia and throughout sub- Saharan Africa, they continue to climb “Better treatment is essential, but if we want to affect longer-term trends in the epidemic we will also have to deal with risk factors,” asserts Eva Rehfuess, a scientist with the WHO Department of Public Health and Environment
  • 51. ECRD.IN SCIENTIFIC EVIDENCE CAN BOLSTER CONTROVERSIAL POLICY DECISIONS? FLYOVERS SKYWALKS
  • 52. ECRD.IN “Those who contemplate the beauty of the earth find reserves of strength that will endure as long as life lasts.”