MRI PHYSICS,MECHANISM OF MRI,MRI THEORY,BASICS OF MRI,FUNDAMENTALS OF MRI,MRI IN BASICAL KNOWLEDGE,

1. MRI PHYSICS
DR. PRABHA JOSEPH

2. Magnetic susceptibility
 The magnetic susceptibility of a substance is the ability of external
magnetic fields to affect the nuclei of a particular atom, and is related
to the electron configurations of that atom.
There are three types of magnetic susceptibility:
 Paramagnetism
 Diamagnetism and
 Ferromagnetism.

3.  Paramagnetic substances contain unpaired electrons within the atom that induce
a small magnetic field about themselves known as the magnetic moment.
 With no external magnetic field these magnetic moments occur in a random
pattern and cancel each other out.
 In the presence of an external magnetic field, paramagnetic substances align with
the direction of the field and so the magnetic moments add together.
PARAMAGNETISM : (oxygen,melanin,gadolinium)

4. DIAMAGNETISM :
 When an external magnetic field is applied, diamagnetic substances show a small
magnetic moment that opposes the applied field
 Examples of diamagnetic substances include water, HG, Cu, C

5. FERROMAGNETISM :
When a ferromagnetic substance
comes into contact with a magnetic
field, the results are strong attraction
and alignment. It retains its
magnetization even when the external
magnetic field has been removed
Ferromagnetic substances remain
magnetic, are permanently magnetized
and subsequently become permanent
magnets. An example of a
ferromagnetic substance is iron, Co,Ni

6. NUCLEAR MAGNETIC RESONANCE :
Nuclear magnetic resonance (NMR) is a physical phenomenon that occurs
when certain elements interact with a magnetic field.
NMR is the process by which the signal detected in MRI is generated
 Elements that demonstrate NMR are
Hydrogen = 1
Phosphorous = 31
Carbon = 13
Fluorine =19
Sodium=23
Nitrogen =15
Oxygen =17

7.  The hydrogen nucleus is the MR active nucleus used in MRI.
 This nucleus consists of a single proton (atomic number 1).
 It is used for MR imaging because:
---it is abundant in the human body (e.g. in fat and water);
---its solitary proton gives it a large magnetic moment

8. Four basic steps are involved in getting an MR image
1. Placing the patient in the magnet
2. Sending Radiofrequency (RF) pulse by coil
3. Receiving signals from the patient by coil
4. Transformation of signals into image by complex
processing in the computers.

9. The signal on clinical MR images comes from
water molecules that are mostly composed of
hydrogen.
Since hydrogen ion (H+) has only one particle,
i.e. proton, it is equivalent to a proton.
Normally the protons in human body (outside
the magnetic field) move randomly in any
direction. When external magnetic field is
applied, i.e. patient is placed in the magnet,
these randomly moving protons align (i.e. their
magnetic moment align) and spin in the
direction of external magnetic field.

10.  Some of them align parallel and others anti-parallel to the external magnetic
field
 When a proton aligns along external magnetic field, not only it rotates
around itself (called spin) but also its axis of rotation moves forming a ‘cone’.
This movement of the axis of rotation of a proton is called as precession

11. The number of precessions of a proton per second is called precession
frequency. It is measured in Hertz.
Precession frequency is directly proportional to strength of external
magnetic field. Stronger the external magnetic field, higher is the precession
frequency. This relationship is expressed by Larmor's equation
Wo = γ Bo
Where wo = Precession frequency in Hz
Bo = Strength of external magnetic field in Tesla
γ = Gyromagnetic ratio, which is specific to particular nucleus
Precession frequency of the hydrogen proton at 1, 1.5 and 3 Tesla
is roughly 42, 64 and 128 MHz respectively.

12. Longitudinal Magnetization
For the orientation in space consider X, Y,
and Z axes system.
External magnetic field is directed along
the Z-axis.
 Protons align parallel and antiparallel to
external magnetic field, i.e. along
positive and negative sides of the Z-axis.
Forces of protons on negative and
positive sides cancel each other.

13.  But this NMV (Longitudinal magnetization) is not measurable.
 Because this NMV is along the external magnetic field (Bo) and it is so small
relative to the static magnetic field Bo (10 million times smaller)
 So For measurement- a magnetisation transrverse to external magnetic
field is necessary
 So it’s the only Transverse vector (rotating in the x-y plain) which produces
signal in the receiver. Longitudinal vector can never produce a signal

14.  Next step is to impart energy to this NMV so as to get a
transverse magnetization which is measurable.
RESONANCE:
 Resonance is an energy transition that occurs when an object is
subjected to a frequency the same as its own
In MR, resonance is induced by applying a radiofrequency (RF)
pulse:
at the same frequency as the precessing hydrogen nuclei;
at 90° to B0.

15.  2 things happen at Resonance (ie when we apply RF pulse B1)
 due to energy absorption: Increase number of High energy Spin
Up nuclei ie nuclei in antiparallel direction to Bo. Causing
gradual decrease in longitudinal magnetisation vector
 increase in Phase Coherence- causing gradual increase in
transverse magnetisation vector.
With 90 deg RF pulse longitudinal vector becomes zero and
transverse vector becomes maximum. So the NMV precesses only
in transverse plain.

16. Transverse Magnetization
The next step is to send radiofrequency (RF) pulse.
 The precessing protons pick up some energy from the radiofrequency
pulse. Some of these protons go to higher energy level and start precessing
antiparallel (along negative side of the Z-axis). The imbalance results in
tilting of the magnetization into the transverse (X-Y) plane. This is called as
transverse magnetization

18. When RF pulse is switched off, LM starts increasing along Z-axis
and TM starts reducing in the transverse plane. The process of
recovery of LM is called Longitudinal Relaxation while reduction in
the magnitude of TM is called as Transverse Relaxation.

20. Effects of switching off the RF pulse
 NMV loses its energy -----Relaxation
 Longitudinal magnetisation gradually increases ----Recovery
 Transverse magnetisation decreases -----Decay

21. The components of magnetization in longitudinal and
transverse planes (i.e. LM and TM) can be represented by a
single vector. This vector represents sum of these
components and is called as net magnetization vector
(NMV). NMV lies some where between LM and TM.

22. T1 or spin lattice relaxation:
T1 is the time taken by LM to recover after RF pulse is switched off
T1 is the time when LM reaches back to 63% of its original value.
The curve showing gradual recovery of LM against time is called T1 curve
T1 recovery is caused by the exchange of energy from nuclei to their
surrounding environment or lattice ----It is called spin lattice energy transfer.

23. T1 depends upon tissue composition,
structure and surroundings
 Fat comprises hydrogen atoms linked to
carbon that make up large molecules. The
large molecules in fat have a slow rate of
molecular motion They also have a low
inherent energy which means they are able
to absorb energy efficiently & dispose energy
to surrounding fat tussue – short T1
Since water molecules are small molecules &
move too rapidly the protons in water take
long time to transfer their energy – Long T1

25.  The TR controls how much of the NMV
in fat or water has recovered before
the application of the next RF pulse
 Short TRs do not permit full
longitudinal recovery in either fat or
water so that there are different
longitudinal components in fat and
water

26. These different longitudinal components
are converted to different transverse
components after the next excitation pulse
has been applied.
As the NMV does not recover completely to
the positive longitudinal axis, they are
pushed beyond the transverse plane by the
succeeding 90° RF pulse. This is called
saturation
When saturation occurs there is a contrast
difference between fat and water due to
differences in T1 recovery using short TRs.

27. Long TRs allow full
recovery of the longitudinal
components in fat and
water.
There is no difference in
the magnitude of their
longitudinal components.
There is no contrast
difference between fat and
water

28. T2 or spin spin relaxation:
T2 is the time taken by TM to disappear.
It is the time taken by the TM to reduce to 37% of its maximum value.
The curve showing decrease in magnitude (decay) of the TM plotted against
time is called T2 curve

29. T2 depends on inhomogeneity of local magnetic fields
within the tissues due to exchange of energy from one
nucleus to another – spin-spin energy transfer
 As water molecules move very fast, their magnetic
fields fluctuate fast. These fluctuating magnetic fields
cancel each other. So there are no big differences in
magnetic field strength inside such a tissue. Because
of lack of much inhomogeneity protons stay in phase
for a long-time resulting into long T2 for water.
The tissue has larger molecules, the molecules move at
slower rate. This maintains inhomogeneity of the
intrinsic magnetic field within the tissue. As a result
protons go out of phase very fast. Hence tissues with
larger molecules have short T2. Fat has shorter T2

30. The TE controls how much transverse
magnetization has been allowed to
decay in fat and water when the signal
is read.
Short TEs do not permit full dephasing
in either fat or water so their
transverse components are similar.
There is little contrast difference
between fat and water due to
differences in T2 decay using short
TEs.
Long TEs allow dephasing of the transverse components in fat and water. There is a
contrast difference between fat and water due to differences in T2 decay times when
using long TEs.

31. T2*
 Decay of the TM caused by combination of spin-spin relaxation and
inhomogeneity of external magnetic field is called T2* relaxation. Dephasing
effects of external magnetic field inhomogeneity are eliminated by 180° RF
pulses used in spin-echo sequence.
TR and TE
A typical spin-echo sequence consists of 90 degree pulse followed by 180
degree pulse. After 180 degree pulse the signal (echo) is received.
TR (Time to Repeat) is the time interval between start of one RF pulse
and start of the next RF pulse

32. TE (Time to Echo) is the time interval between start of RF pulse and
reception of the signal (echo).
Short TR and short TE gives T1 weighted images.
Long TR and long TE gives T2 weighted images.
Long TR and short TE gives Proton density images.
TR is always higher than TE.

33. TI
 TI is Time of Inversion. It is the time between inverting 180
degree pulse and 90 degree pulse in Inversion Recovery (IR)
sequence
FID :
As the magnitude of transverse magnetisation decreases , the
magnitude of voltage induced in receiver coil also decrease.
The induction of reduced signal is called FREE INDUCTION
DECAY SIGNAL.

34. FLIP ANGLE
This is the angle through which
the NMV is moved as a result of a
RF excitation pulse

35.  A tissue has high signal (white, hyperintense) if it has large TM
 A tissue has a low signal (black, hypointense) – vice versa
 A tissue has an intermediate signal (grey, isointense) - medium
TM

36. BASIC SEQUENCES
T1 WEIGHTED IMAGES
o Short TR and short TE gives T1 weighted images
o Fat has a shorter T1 relaxation time than water ;by
its short T1 relaxation time, fat will recover quicker
from longitudinal magnetization (Z axis).
o When a second radiofrequent pulse of 90 degrees
is given, water will not have fully recovered in the
longitudinal plane. After the second pulse, fat will
make a larger deflection than water and create
more transversal magnetization. The higher the
transversal magnetization of the tissue, the more
signal is received.

37. Typical parameters
TR 300–600 ms (shorter in gradient echo
sequences)
TE 10–30 ms (shorter in gradient echo
sequences)

38. T2 WEIGHTED IMAGES
Long TR and long TE gives T2 weighted
images
Typical
parameters
TR 2000 ms +
TE 70 ms +

39. PROTON DENSITY WEIGHTED IMAGING
Differences in the proton densities (number of hydrogen
protons in the tissue) demonstrated.
 Both T1 and T2 effects diminished - T1 by long TR and T2 short
TE .
 Tissues with low proton density dark (low signal, hypointense)
because the low number of protons results in a small
component of TM.
 Tissues with a high PD are bright (high signal, hyperintense

41. PULSE SEQUENCE MECHANISMS
 Pulse sequences are required because, there is insufficient
signal to produce an image. This is because dephasing occurs
almost immediately after the RF excitation pulse has been
removed.
 Spins lose their phase coherence in two ways:
• by the interactions of the intrinsic magnetic fields of adjacent
nuclei; spin–spin energy transfer
• by the inhomogeneities of the external magnetic field.
Magnetic field inhomogeneities cause the NMV to dephase
before intrinsic magnetic fields of the nuclei can
produce dephasing, i.e. T2* happens before T2.

42. The main purposes of pulse sequences are:
 to rephase spins and remove inhomogeneity effects and therefore
produce a signal or echo that contains information on the decay
characteristics of tissue;
 to enable manipulation of the TE and TR to produce different types
of contrast.
 Spins are rephased in two ways
o by using a 180° RF pulse
o by using a gradient.

44. The conventional spin echo pulse sequence (SE)
 Conventional spin-echo (SE or CSE) pulse sequences are used to
produce T1, T2 or proton density weighted images
 In a spin echo pulse sequence there is a 90° excitation pulse followed
by a 180° rephasing pulse followed by an echo
Mechanism :
 After the application of the 90° RF pulse, spins lose precessional
coherence because of an increase or decrease in their precessional
frequency caused by the magnetic field inhomogeneities.
This results in a decay of coherent magnetization in the transverse plane
and the ability to generate a signal is lost

45. Spins that experience an increase in
precessional frequency gain phase
relative to those that experience a
decrease in precessional frequency who
lag behind.
 Dephasing can be imagined as a ‘fan’
where spins that lag behind precess
more slowly, and those that gain phase
precess more quickly. •
A 180° RF pulse flips magnetic
moments of the dephased spins through
180°.
 The fast edge of the fan is now
positioned behind the slow edge. The
fast edge eventually catches up with the

46. The coherent signal in the receiver coil is regenerated and can be measured. This
regenerated signal is called an echo and, because an RF pulse has been used to
generate it, it is specifically called a spin echo.
Rephasing the spins eliminates the effect of the magnetic field inhomogeneities.

47. A dual echo sequence consists of two
180° pulses applied to produce
two spin echoes.
 This is a sequence that provides two
images per slice location: one that is
proton density weighted and one
that is T2 weighted
 The first echo has a short TE and a
long TR and results in a set of
proton density weighted images.
• The second echo has a long TE and a
long TR and results in a T2
weighted set of images.

49. Fast or turbo spin echo
Mechanism
 TSE employs a train of 180°
rephasing pulses, each one
producing a spin echo. This train of
spin echoes is called an echo
train. The number of 180° RF
pulses and resultant echoes is
called the echo train length (ETL)
or turbo factor.
The spacing between each echo is
called the echo spacing.

50. After each rephasing, a phase-encoding step is performed and data from the
resultant echo is stored in K space
Therefore several lines of K space are filled every TR instead of one line as in
conventional spin echo.
As K space is filled more rapidly, the scan time decreases.
Typically 2 to 24 180° RF pulses are applied during every TR. As several phase
encodings are also performed during each TR, the scan time is reduced.
For example, if a factor of 16 has been used, 16 phase encodings are
performed per TR and therefore 16 lines of K space are filled per TR instead of
1 as in conventional spin echo.
Therefore the scan time is 1/16 of the original scan time
The higher the turbo factor the shorter the scan time.

51. Each echo has a different TE and data from each echo is used to produce one
image
In any sequence, each phase encoding step applies a different slope of phase
gradient to phase shift each slice by a different amount. This ensures that data is
placed in a different line of K space.
The very steep gradient slopes significantly reduce the amplitude of the resultant
echo/signal because they reduce the rephasing effect of the 180° rephasing pulse.
Shallow gradients, on the other hand, do not have this effect and the amplitude of
the resultant echo/signal is maximized
The TE at which the center of the K-Space is filled is called as ‘TE effective’.
Short turbo factor decreases effective TE and increases T1 weighting. However, it
increases scan time.
Long turbo factor increases effective TE, increases T2 weighting and reduces scan

52. A modification of TSE that is sometimes called fast recovery or drive
adds an additional ‘reset’ pulse at the end of the TR period. This pulse
‘drives’ any residual magnetization in the transverse plane at the end of
each TR back into the longitudinal plane This is then available to be
flipped into the transverse plane by the next excitation pulse.

53. Inversion recovery
Inversion recovery is a spin echo
sequence that begins with a 180°
inverting pulse. This inverts the NMV
through 180°.
The TR is the time between successive
180° inverting pulses for a particular
slice.
When the pulse is removed the NMV
begins to relax back to B0.
 A 90° pulse is then applied at time
interval TI (time from inversion) after the
180° inverting pulse.
 A further 180° RF pulse is applied which
rephases spins in the transverse plane
and produces an echo at time TE after

54.  STIR (short TI inversion recovery) uses short TIs such as 100–180 ms depending on field
strength. TIs of this magnitude place the 90° excitation pulse at the time that NMV of fat is
passing exactly through the transverse plane. At this point (called the null point) there is
no longitudinal component in fat. Therefore the 90° excitation pulse produces no
transverse component in fat and therefore no signal. In this way a fat-suppressed image
results
 FLAIR (fluid attenuated inversion recovery) uses long TIs such as 1700–2200 ms depending
on field strength to null the signal from CSF in exactly the same way as the STIR sequence.
Because CSF has a long T1 recovery time, the TI must be longer to correspond with its null
point.

55. THANK YOU

56. GRADIENTS FUNCTIONS :
 Gradients are coils of wire that, when a current is passed through them, alter the magnetic
field strength of the magnet in a controlled and predictable way.
 They add or subtract from the existing field in a linear fashion so that the magnetic field
strength at any point along the gradient is known

57. When a gradient is applied the following occur:
At isocenter the field strength remains
unchanged even when the gradient is switched
on.
At a certain distance away from iso-centre the
field strength either increases or decreases
The slope of the gradient signifies the rate of
change of the magnetic field strength along its
length.
The strength or amplitude of the gradient is
determined by how much current is applied to
the gradient coil. Larger currents create steeper
gradients so that the change in field
strength over distance is greater. The reverse is

58. Gradient echo pulse sequences:
Are sequences that use a gradient to rephase spins, as opposed to a
180° RF pulse used in spin echo sequences.