all details about the absorption of drugs

1. ABSORPTION OF DRUGS
INTRODUCTION:-
Absorption is the movement of drug from its site of administration into the circulation.
Factors affecting absorption are:-
Aqueous solubility- Drugs given in solid form must dissolve in the aqueous biophase before they are absorbed.
For poorly water-soluble drugs (aspirin, griseofulvin) rate of dissolution governs rate of absorption.
Concentration- Passive transport depends on concentration gradient;
drug given as concentrated solution is absorbed faster than from dilute solution.
Area of absorbing surface Larger it is faster is the absorption.
Vascularity of the absorbing surface Blood circulation removes the drug from the site of absorption and
maintains the concentration gradient across the absorbing surface.
Route of administration This affects drug absorption,because each route has its own peculiarities.
Oral
The effective barrier to orally administered drugs is the epithelial lining of the gastrointestinaltract, which is
lipoidal.
Nonionized lipid-soluble drugs, e.g. ethanol are readily absorbed from stomach as well as intestine at rates
proportional to their lipid:water partition coefficient.
Acidic drugs{Salcylates,Barbiturates) absorbed in Stomach.
Basic drugs{Morphine,Quinine} absorbed in Duodenum.
Subcutaneous and intramuscular
By these routes the drug is deposited directly in the vicinity of the capillaries.
Lipid-soluble drugs pass readily across the whole surface of the capillary endothelium.
Capillaries being highlyporous do not obstruct absorption ofeven large lipid-insoluble molecules or ions.
Very large molecules are absorbed through lymphatics.
ORALLY SUBCUTANEOUS INTRA-MUSCULAR
e.g. benzathine penicillin, protamine zinc insulin, depot progestins,etc.
Topical sites (skin, cornea, mucous membranes)-
Systemic absorption after topical application depends primarily on lipid solubility of drugs.
SKIN:- Glyceryl trinitrate, fentanyl and estradiol

2. Drugs significantly penetrate intact Skin
CORNEA:-
It is permeable to lipid soluble.
Permeable unionized physiostigmine but not permeable highly ionized neostigmine
MUCOUS MEMBRNE:-
Musous memb. of mouth, rectum, absorbed lipophilic drugs.
BIOAVAILABILITY:-
Bioavailability refers to the rate and extent of absorption of a drug from a dosage form as determined by its
concentration-time curve in blood or by its excretion in urine.
Plasma concentration-time curves depicting bioavailability differencesbetween three preparations of a drug containing the same
amount
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