8. “biologically and histologically is a
composite of morphogenetic and
histogenetic change occurring continuously
over a period of time in response to genetic
coding and environmental influences”.
Growth
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
9. “To take advantage of the growth, we must have
some idea, first, of its amount, second of its
direction and third the element of timing”
Ricketts:
Along with this we need to know when the major growth
increments are likely to occur
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
10. Combination
Why to Assess?
Growth is a critical factor in
Orthodontic and Orthopaedic Diagnosis Treatment Planning
&
Orthopaedic Intervention
OrthodonticTherapy
Orthognathic Surgery
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
15. • Todd Greulich & Pyle
• Bjork 8 development stages
• Grave and Brown 6 ossification centers
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
16. • Fishman
• Hagg and Taranger 5 Stages of MP3 growth
• Tanner et al, Houston et al, Chapman Rajagopal et al,
Madhu et al
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
19. Hand wrist radiographs
• Hand wrist region:
- Made up of numerous small bones
• These bones show:
-Predictable & scheduled pattern of
appearance
-Ossification
-& union from birth to maturity.
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
20. • Thus by merely comparing a patient’s hand wrist
radiograph with standard radiographs that represent
different skeletal ages, we will be able to determine the
skeletal maturation status of that individual.
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
23. Anatomy of hand wrist: 4 bones
•Distal ends of long bones of forearm :
- Radius & ulna (long bones) forms the first group of
bones.
- Ulna on medial aspect & radius on distal aspect.
- Give rise to distal projections respectively called ulnar
styloid & radial styloid.
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
25. Phalanges
- Small bones forming the fingers.
- 3 in number in each finger, except thumb which has two
phalanges.
- The phalanges have a pattern of ossification which can be
divided in to three stages:
Stage 1: epiphysis and diaphysis are equal
Stage 2 : epiphysis caps diaphysis
Stage 3 : fusion occurs between epiphysis and diaphysis.
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
28. The Carpals
- 8 small, irregularly placed bones arranged in a proximal &
a distal row.
- Bones of proximal row: scaphoid, lunate, triquetral &
pisiform.
- Bones of distal row: trapezium, trapezoid, capitate &
hamate.
All these ossifies from one primary center.
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
29. - 5 miniature long bones
- Forms the skeletal framework of palm of hand.
- 1 to 5 in number, thumb to little finger.
- Each metacarpal ossify from one primary center ( in its shaft)
& secondary center on distal end.
Metacarpals
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
30. Indications of hand
wrist radiographs
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
33. Commonly used methods are:
• Atlas Method by Greulich and Pyle
• Bjork, Grave and Brown Method
• Singer’s Method ofAssessment
• Fishman’s Skeletal Maturity Indicator
• Hagg andTaranger Method
Phulari BS, Orthodontics Principles and Practice, Edition 1;205-15
34. Width of Epiphysis = Diaphysis
PP2
Stage 1 MP3
Stage 2
PP2
MP3
3 years before the peak of pubertal growth
♂ - 10.6 yrs. ♀ - 8.1 yrs. ♂ - 12 yrs. ♀ - 8.1 yrs.
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
35. H1 - stage
Visible ossification
Pisiform Bone
Pisi - stage R - stage
Ossification of Hamular
Process of Hamate
Epiphysis = Diaphysis of
Radius
♂ - 12.6 yrs. ♀ - 9.6 yrs.
Pisiform Bone
Hamular Process of Hamate
Radius
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
36. H2 - stage
First mineralization
of Sessamoid Bone
S - stage
ProgressiveOssification of
Hamular Process of Hamate
♂ - 13 yrs. ♀ - 10.6 yrs.
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
37. 1
3
2
4
5
Capping of Epiphysis
PP1cap - stage MP3cap - stage
Peak of the Pubertal growth
♂ - 14 yrs. ♀ - 11 yrs.
Rcap - stage
PP1
MP3
Radius
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
38. Union of Epiphysis
♂ - 15 yrs. ♀ - 13 yrs.
DP3u - stage
1
3
2
4
5
DP3
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
39. ♂ - 15.9 yrs. ♀ - 13.3 yrs.
PP3u - stage
1
3
2
4
5
PP3
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
40. ♂ - 15.9 yrs. ♀ - 13.9 yrs.
MP3u - stage
1
3
2
4
5
MP3
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
41. • Skeletal growth is
finished
♂ - 18.5 yrs. ♀ - 16 yrs.
Ru - stage
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
42. 1st – 3rd Stage 4th & 5th Stage 6th – 9th Stage
Corresponds to 3 years before
the peak pubertal growth period.
Prognosis is good if growth
modification is planned
Residual growth potential –
fixed functional appliances can
be planned
Union stage –no chance for
functional appliance therapy
Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent 2018; 8(6):482.
43. 4 Stages of Bone Maturation
Epiphysis equal in
width to diaphysis
Appearance of adductor
sesamoid of the thumb
Capping of epiphysis Fusion of epiphysis
1st Stage 2nd Stage
3rd Stage 4th Stage
Fishman L S. Radiographic evaluation of skeletal maturation. Angle Orthod ; 1982; 52:89-111
44. 6 Anatomical Sites
Thumb - Sesamoid
Third finger – PP3, MP3, DP3
Fifth finger – MP5
Radius
Fishman L S. Radiographic evaluation of skeletal maturation. Angle Orthod ; 1982; 52:89-111
46. Ossification
Adductor sesamoid
Thumb
No?
Width
1. PP3
Width
2. MP3
Width
3. MP5
Yes?
Fusion
8. DP3
Capping Fusion
5. DP3
6. MP3
7. MP5
9. PP3
10. MP3
11. Radius
No Yes
Fishman L S. Radiographic evaluation of skeletal maturation. Angle Orthod ; 1982; 52:89-111
47. • Stages of ossification of the sessamoid, middle and distal
phalanx of third finger and the epiphyses of the radius are
considered
• Five stages of development of MP3 region
1. MP3F stage 4. MP3-H stage
2. MP3-FG stage 5. MP3-I stage
3. MP3-G stage
Hagg U,Taranger J .Maturational indicators and the pubertal growth spurt. Am J Orthod, 1982; 88:299-309.
48. Modified Hagg and Taranger
A comparison between cervical vertebrae and modified MP3 stages for the assessment of skeletal maturity J Nat Sci Bio Med 4(1):74-80
49. A comparison between cervical vertebrae and modified MP3 stages for the assessment of skeletal maturity J Nat Sci Bio Med 4(1):74-80
50. MP3-HI stage modification by Rajgopal and Kansal
A comparison between cervical vertebrae and modified MP3 stages for the assessment of skeletal maturity J Nat Sci Bio Med 4(1):74-80
51. Method by Greulich
and Pyle
• In 1937, an atlas, “Atlas of Skeletal Maturation of the Hand”
published byTodd.
• Greulich and Pyle based their atlas partly on the atlas by
Todd.
• Since their atlas was first published in 1950 they were able
to use all the radiographs obtained in the original study.
Widek T, Genet P, Ehammer T, Schwark T, Urschler M. Bone age estimation with the Greulich-Pyle atlas using 3T MR images of hand and wrist. Foren Sci Int 2021 ;319:110654.
52. • In order to determine the skeletal age using the modified Greulich
and Pyle method one uses the atlas that they have developed.
• The sex of the patient is one of the most important pieces of
information, because females develop quicker than males.
• The atlas is divided into two parts, one for the male patients and
one for the female patients.
• Each part contains standard radiographic images of the left hand
of children ordered by chronological age.
Widek T, Genet P, Ehammer T, Schwark T, Urschler M. Bone age estimation with the Greulich-Pyle atlas using 3T MR images of hand and wrist. Foren Sci Int 2021 ;319:110654.
53. • The first step in an analysis is to compare the given
radiograph with the image in the atlas that corresponds
closest with the chronological age of the patient.
• Next one should compare it with adjacent images
representing both younger and older children.
• When comparing the radiograph against an image in the
atlas there are certain features a physician should use as
maturity indicators.
Widek T, Genet P, Ehammer T, Schwark T, Urschler M. Bone age estimation with the Greulich-Pyle atlas using 3T MR images of hand and wrist. Foren Sci Int 2021 ;319:110654.
54. Singer’s method of assessment
- Stage1: (early):
- Stage 2: (prepubertal):
Singer J. Physiologic timing of orthodontic treatment. Angle Orthod 1980; 50:320-333.
56. Cervical vertebrae maturation as an
indicator of skeletal maturity
In a study done by Paola it was seen thatVertebral analysis on a lateral
cephalogram is as valid as the hand-wrist bone analysis with the
advantage of reducing the radiation exposure of growing subjects.
Angle Orthodontist 2006;76 (6)
57. CVMI 1- Initiation:
•Inferior borders of 2nd 3rd and 4th
cervical vertebrae are flat at this stage.
•The third and fourth vertebrae are
wedge shaped and the superior vertebral
borders are tapered from posterior to
anterior.
•100% of pubertal growth remains.
•Very significant amount of adolescent
growth expected. CVMI STAGES by Hassel and Farman (1995)
Hassel B, Farman A G. Skeletal maturation evaluation using cervical vertebrae. Am J Orthod, 1995; 107:58-61
58. CVMI 2 -Acceleration:
• Concavities on the inferior borders of
second and third vertebrae begin to
develop.
• Inferior border of fourth vertebrae
remains flat.
• Vertebral bodies of third and fourth
are nearly rectangular in shape.
• 65-85% of pubertal growth remains.
Hassel B, Farman A G. Skeletal maturation evaluation using cervical vertebrae. Am J Orthod, 1995; 107:58-61
59. CVMI 3- Transition
•Distinct concavities are shown on the
inferior borders of second and third
vertebrae.
• A concavity begins to develop on the
inferior border of fourth vertebrae.
•Vertebral bodies of third and fourth are
rectangular in shape.
• 25-65% of pubertal growth remains.
Hassel B, Farman A G. Skeletal maturation evaluation using cervical vertebrae. Am J Orthod, 1995; 107:58-61
60. CVMI 4- Deceleration stage
• Distinct concavities can be observed on
the inferior borders of second, third and
fourth cervical vertebrae.
• Vertebral bodies of third and fourth
begin to be more square in shape.
• 10-25% of pubertal growth remains.
Hassel B, Farman A G. Skeletal maturation evaluation using cervical vertebrae. Am J Orthod, 1995; 107:58-61
61. CVMI 5- Maturation stage
• Marked concavities are
observed on the inferior borders
of second, third and fourth cervical
vertebrae.
•Vertebral bodies of third and
fourth are almost square in shape.
• 5-10% of pubertal growth
remains. Hassel B, Farman A G. Skeletal maturation evaluation using cervical vertebrae. Am J Orthod, 1995; 107:58-61
62. CVMI 6- Completion
• Deep concavities are observed on
the second, third and fourth cervical
vertebrae.
• Vertebral bodies are greater vertically
than horizontally.
• Pubertal growth has been completed.
Hassel B, Farman A G. Skeletal maturation evaluation using cervical vertebrae. Am J Orthod, 1995; 107:58-61
63. Frontal sinus development as an
indicator for somatic maturity at
puberty
Ruf and Pancherz (1996)
Sabine Ruf and Hans Pancherz evaluated the development of
the frontal sinus to the longitudinal data of the subject’s growth
charts.
Results showed that Frontal sinus growth velocity at puberty is
closely related to body height growth velocity.
Ruf S, Pancherz H. Frontal sinus development as an indicator for somatic maturity at puberty?. Am J Orthod Dentofac Orthop 1996 1;110(5):476-82.
64. The peripheral border of the frontal sinus was traced, and the
highest (Sh) and lowest (Sl) points of the sinus extension
relative to the nasion sella line were marked. Perpendicular to
the interconnecting line (Sh-S1), the maximum width of the
frontal sinus was assessed
Ruf S, Pancherz H. Frontal sinus development as an indicator for somatic maturity at puberty?. Am J Orthod Dentofac Orthop 1996 1;110(5):476-82.
65. Frontal sinus shows a well defined pubertal peak (Sp), which on
an average, occurs 1.4 years after the pubertal body height
peak. (Bp).
Ruf S, Pancherz H. Frontal sinus development as an indicator for somatic maturity at puberty?. Am J Orthod Dentofac Orthop 1996 1;110(5):476-82.
66. Mid Palatal Suture
Revelo B,Fishman LS. Maturational evaluation of ossification of midpalatal suture. Am J Orthod, 1994;105:288-292
67. The purpose of this study was to determine whether a
positive correlation exists between adolescent
maturational development and the approximation of the
mid palatal suture
The mid palatal suture is formed by three parts.These
include :
-Interpremaxillary
-Maxillary
-Interpalatine
Revelo B,Fishman LS. Maturational evaluation of ossification of midpalatal suture. Am J Orthod, 1994;105:288-292
68. The following key landmarks and planes were
identified :
Point A – most ant. point of the premaxilla
Point B – most post. point on the posterior wall of
incisive foramen
Point P – point tangent to a line connecting the
posterior walls of the greater palatine foramens
Revelo B,Fishman LS. Maturational evaluation of ossification of midpalatal suture. Am J Orthod, 1994;105:288-292
69. Result
Stages of ossification of the midpalatal suture were
compared with the Fishman’s standards of skeletal
maturation indicators.
Very little mid palatal approx. existed during SMI 1 – 2.
Revelo B,Fishman LS. Maturational evaluation of ossification of midpalatal suture. Am J Orthod, 1994;105:288-292
70. Very large increases in approximation from SMI 8 –
11
Maturational development is related to mid palatal
fusion in ways that can provide information to better
time maxillary expansion
It is best to accomplish this before SMI 9 and ideal
time to initiate it is between SMI 1 – 4
Revelo B,Fishman LS. Maturational evaluation of ossification of midpalatal suture. Am J Orthod, 1994;105:288-292
72. • Fishman L S,” Radiographic evaluation of skeletal maturation”.Angle
Orthod ; 1982; 52:89-111
• A comparison between cervical vertebrae and modified MP3 stages for the
assessment of skeletal maturity. Journal of Natural Science Biology and
Medicine 4(1):74-80
• Hashim HA, Mansoor H, Mohamed MH. Assessment of skeletal age using
hand-wrist radiographs following Bjork system. J Int Soc Prev Comm Dent
2018; 8(6):482.
• Ruf S, Pancherz H. Frontal sinus development as an indicator for somatic
maturity at puberty?. Am J Orthod DentofacOrthop 1996 1;110(5):476-82.
• WidekT, Genet P, EhammerT, SchwarkT, Urschler M, Scheurer E. Bone age
estimation with the Greulich-Pyle atlas using 3T MR images of hand and
wrist. Foren Sci Int 2021 ;319:110654.
