Generation of transgenic non human primates with germline transmission
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Int J Mol Epidemiol Genet. 2011 Aug 30;2(3):228-35. Epub 2011 Jun 5.
Emergence of unique variants and inter-genotype recombinants of
human astroviruses infecting infants, children and adults in Kolkata,
India.
Pativada MS, Chatterjee D, Mariyappa NS, Rajendran K, Bhattacharya MK, Ghosh M, Kobayashi N,
Krishnan T.
Abstract
Two conserved genomic fragments viz. 289bp of ORF1a and 449bp of ORF2 amplified by
RT-PCR showed emergence of interesting recombinant strains representing new and novel
genetic variants (n=5) within eight different genotypes of astroviruses known to date. HAstV-
positive cases with ORF1a [HAstV genotype G2 or G8] and ORF2 [HAstV genotype G1, G2, or
G3] were detected as sole or mixed infection among infants, children and adults in Kolkata with
severe illness owing to acute gastroenteritis that required hospitalization for treatment between
2007 and 2009. The twelve interesting recombinants were of type HAstV _ ORF1a _ ORF2 as
HAstV _ G8_ G2 (n=1), HAstV _ G8_ G1 (n=10) and HAstV _ G2_ G3 (n=1).
Human astrovirus inter-genotype recombinants; acute gastroenteritis; genotyping; unique
emerging variants for ORF1a and ORF2
PMID: 21915361 [PubMed] PMCID: PMC3166150 Free PMC Article
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Emergence of unique variants and inter-genotype recombinants ... http://www.ncbi.nlm.nih.gov/pubmed/21915361
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Emergence of unique variants and inter-genotype recombinants ... http://www.ncbi.nlm.nih.gov/pubmed/21915361
2 of 2 29/12/15 4:09 pm