RNA transcriptiom is the process in charge of the synthesis of the RNA 5' --> 3'strand from a 3' --> 5' DNA strand.

1. RNA
TRANSCRIPTION
David Herrera Correa
Medical Student

4. INTRODUCTION

5. Cellagingslowedbyputting
brakesonnoisytransciption
PerelmanMedicineSchoolat
the UniversityofPennsylvania
(30July2015)

6. Cell aging slowed by putting brakes
on noisy transciption

7. Cell aging slowed by putting brakes
on noisy transciption

8. Cell aging slowed by putting brakes
on noisy transciption

9. This kind of studies are
incredibly important at the
moment, because we can
not only increase our
lifespan but also taking
new steps into genetic
therapy, stoping the
division cicle and so,
developing new treatments
for terminal diseases.

10. Glimmerof hope for
patients with
leukodystrophies
McGill UniversityHealth Centre
(8 July 2015)

11. Glimmer of hope for patients
with leukodystrophies
DEGENERATION OF THE WHITE
MATTER IN THE BRAIN.
Caused by imperfection in the
growing or formation of the mielin.

12. Glimmer of hope for patients
with leukodystrophies

13. Glimmer of hope for patients
with leukodystrophies
"The cells' lack of ability to produce RNA polymerase III
compromises the genetic program controlled by this
enzyme, thereby inducing a particularly harmful effect in
specialized nerve cells."

14. Like the autors said, this
research serve as a way of
knowing how is the right way
to treat therapeuticaly a
patient with this
leukodystrophy, to make new
diagnosis and as well to
‘‘light on the molecular
mechanism’’ of this one.

15. Medical Utility

16. Medical Utility

17. Medical Utility
Special treatment for
patients with POLR1C
mutation.
Desing of new drugs and diagnosis with
genes mutations

18. Medical Utility
Correction of POLR1C mutation
and abnormals chemical reactions
of chromatin.

19. Bibliography
• · Perelman School of Medicine at the University of
Pennsylvania. "Cell aging slowed by putting brakes on noisy
transcription." ScienceDaily, Retrieved 30 July 2015 from
www.sciencedaily.com/releases/2015/07/150730172605.htm
• · McGill University Health Centre. "Glimmer of hope for
patients with leukodystrophies: A new crucial gene associated
with these orphan diseases discovered." ScienceDaily.
Retrieved 8 July 2015 from
www.sciencedaily.com/releases/2015/07/150708123321.htm
• TORO GÓMEZ, Jaime; YEPES SANZ, Manuel; PALACIOS
SÁNCHEZ, Eduardo. Neurología. 2°edición. Editorial Manual
moderno, 2010. 385p.