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A.) Chromosomes. Describe the overall structure of chomosomes, including centromere,
telomere, and origin of replication.
B.) Condensation of eukaryotic chromosomes. (i) Using your knowledge of the molecular
dimensions of the double helix of DNA (question 13) and assuming that the human genome is 5
billion bases long: how long is the entire genome in a single human cell if it were to be stretched
out? Hoes does this compare to the size of a typical nucleus? (ii) Describe the mechanisms of
chromophore condensation, including nucleosomes, histones, chromatin remodeling, and
euchromatin versus heterochromatin. (iii) List key differences between chromosomes in bacteria
and eukaryotes.

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