This document discusses several dietary supplements and their potential effects on blood sugar levels and diabetes: - Conjugated linoleic acid may worsen blood sugar control in type 2 diabetics and those at risk, so blood sugar should be monitored when taking it. - High doses of vitamin E (>400 IU/day) can lower blood pressure in diabetics, so blood pressure should be monitored. - Ginkgo biloba can change insulin levels in the body, so diabetics should monitor their blood sugar when taking it, as it is not clear if it will increase or decrease levels. - Selenium supplementation may increase the risk of type 2 diabetes.

1. 糖尿病要小心
的保健食品
周孫鴻藥師

2. CLA
共軛亞油酸

3. • 影響 : 惡化血糖控制
• 建議 : 第二型糖尿病 , 或是有糖尿病風險者
( 例如代謝症候群 )~ 服用共軛亞油酸需要
監測血糖
Moloney F, Yeow TP, Mullen A, et al. Conjugated linoleic acid supplementation, insulin
sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin
Nutr. 2004;80:887-895.
Riserus U, Arner P, Brismar K, et al. Treatment with dietary trans10cis12 conjugated linoleic
acid causes isomer-specific insulin resistance in obese men with the metabolic
syndrome. Diabetes Care. 2002;25:1516-1521.

4. 維他命 E

5. • 影響 : 降低糖尿病人的血壓
• 建議 : 糖尿病病人服用高劑量維他命
E(>400 IU/ 天 ) 時 , 須監測血壓
Ward NC, Wu JH, Clarke MW, et al. The effect of vitamin E on blood pressure in individuals
with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. J
Hypertens. 2007;25:227-234.

6. 銀杏

7. • 影響 : 改變體內胰島素的量
• 建議 : 糖尿病病人服用銀杏時 , 須監測血糖
~ 因為目前只知有影響 , 但還不知會升高或
是降低血糖
Kudolo GB. The effect of three- month ingestion of Ginko Biloba extract (EGb 761) on
pancreatic b-cell function in response to glucose loading in individuals with non-insulin
dependent diabetes mellitus. J Clin Pharmacol. 2001;41:600-611.
Sugiyama T, Kubota Y, Shinozuka K, et al. Ginkgo biloba extract modifies hypoglycemic
action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats. Life
Sci. 2004;75:1113-1122.

8. Selenium 硒

9. • 影響 : 增加第二型糖尿病機率
Stranges S, Marshall JR, Natarajan R, et al. Effects of long-term Selenium supplementation
on the incidence of Type 2 diabetes.Ann Intern Med. 2007 July 9.

10. • 影響 : 增加第二型糖尿病機率
Stranges S, Marshall JR, Natarajan R, et al. Effects of long-term Selenium supplementation
on the incidence of Type 2 diabetes.Ann Intern Med. 2007 July 9.