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Breast cancer
Dr Chea Chan Hooi
General & Laparoscopic Surgeon
Borneo Medical Centre (Miri)
11th November 2020
Content
• Introduction
• Basics
• Risk factors
• Symptoms
• Investigations
• Treatment
• Conclusion
Introduction
• Cancer arising from breast tissue
• The most common cancer in Malaysia
• 1 in 20 Malaysian women will develop breast cancer in their lifetimes
• 48% of patients present in stages 3 and 4, only 1/2 survive >5 years
after diagnosis
Cancer cases in Malaysia
Basics
Progression to cancer
basement
membrane
basement membrane
Risk factors
• Sedentary lifestyle
• Poor dietary habits high in sugar
and fat besides processed meat
• Obesity
• Never had full-term pregnancy
• Never breast-fed >6 months
• First childbirth >35 year-old
• Oral contraceptive pills >10 years
• Post-menopausal hormone
replacement therapy >4 years
• Smoking • Excessive alcohol consumption
• Radiotherapy to chest <30 year-old
• Gender
• Vast majority of patients are
women
• Men can also develop breast
cancer (0.1%)
• Race
• Age >40 years old
• Genetics & family history of breast or ovarian cancers
• Started menstruating <10 year-old and stopped >55 year-old
Symptoms
*retrieved from knowyourlemons.com
Peau d'orange
0.1% of breast cancer patients are men
Investigations
Ultrasonography Mammography
• Fine needle aspiration
• Obtain cells for microscopic
examination
• Less reliable
• Biopsy
• Obtain tissue sample for
microscopic examination
• “...diagnosed upon the basis of a
microscopic examination of the
fixed tissue, supported by a biopsy
result.”
• CT scan
• To assess distant spread
Treatment options
• Surgery
• Chemotherapy
• Radiotherapy
• Hormonal therapy
• Targeted therapy
Breast surgery
Mastectomy Lumpectomy/Breast-conserving surgery
Quadrantectomy
Axillary (armpit) surgery
Axillary dissection Sentinel lymph node biopsy
Treatment options
• Surgery
• Chemotherapy
• Radiotherapy
• Hormonal therapy
• Targeted therapy
Oncologist
Survival
Conclusion
• Breast cancer is very common
• Early detection saves lives
• Various modalities available for early detection
• Everyone associated with healthcare has a role to play to reduce its
incidence
References
• 1 Worldwide cancer data global cancer statistics for the most common cancers. World Cancer Reserach Fund International. Available: https://www.wcrf.org/dietandcancer/cancer-trends/worldwide-cancer-
data#:~:text=Lung%20and%20breast%20cancers%20were,million%20new%20cases%20in%202018.
• 2 Azizah Ab M, Nor Saleha IT, Noor Hashimah A, Asmah ZA, Mastulu W. Malaysian National Cancer Registry Report 2007 - 2011 Malaysia cancer statistics, data & figure. National Cancer Institute, Ministry of
Health Malaysia
• 3 Yip CH, Nur Aishah MT, Ibraham M. Epidemiology of breast cancer in Malaysia. Asian Pac J Cancer Prev 2006;7(3):369-74.
• 4 Nor Aini, Wan Rozita WM, Nor Asiah M, et al. Survival rate of breast cancer patients in Malaysia: a population-based study. Asian Pac J Cancer Prev 2013;14(8):4591-4.
• 5 Cui X, Dai Q, Tseng M, et al. Dietary patterns and breast cancer risk in The Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers 2007;16:1443-8.
• 6 Sun YS, Zhao Z, Yang ZN, et al. Risk factors and preventions of breast cancer. Int J Biol Sci 2017;13(11):1387-1397
• 7 Horn J, Asvold BO, Opdahl S. et al. Reproductive factors and the risk of breast cancer in old age: a Norwegian cohort study. Breast Cancer Res Treat 2013;139:237–43.
• 8 Soroush A, Farshchian N, Komasi S. et al. The role of oral contraceptive pills on increased risk of breast cancer in Iranian populations: a meta-analysis. J Can Prev 2016;21:294–301.
• 9L iu JY, Chen TJ, Hwang SJ. The risk of breast casncer in women using menopausal hormone replacement therapy in Taiwan. Int J Environ Res Pub Health 2016;13:482.
• 10 Hamajima N, Hirose K, Tajima K, et al. Alcohol, tobacco and breast cancer-collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067
women without the disease. Br J Cancer 2002;87:1234–45.
• 11 Brewer HR, Jones ME, Schoemaker MJ, Ashworth A, Swerdlow AJ. Family history and risk of breast cancer: an analysis accounting for family structure. Breast Cancer Rest Treat 2017;165(1):193-200.
• 12 American Cancer Society. Radiation therapy for Hodgkin lymphoma. Available: https://www.cancer.org/cancer/hodgkin-
lymphoma/treating/radiation.html#:~:text=Radiation%20therapy%20uses%20high%2Denergy,one%20part%20of%20the%20body.
• 13 Dai Q, Shu XO, Jin F, Gao YT, Ruan ZX, Zheng W. Consumption of animal foods, cooking methods, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2002;11:801–8
• 14 Fu Z, Deming SL, Fair AM, et al. Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: the Nashville Breast Health Study. Breast Cancer Res Treat 2011;129:919–28
• 15 Tao P, Li H, Wang Q, Cao LQ, Li JY, Yang F, Wang YP. A case-control study on association of SULT1A1 polymorphism, smoked meat intake with breast cancer risk. Zhonghua Yu Fang Yi Xue Za Zhi 2012;46:831–5
• 16 Dong JY, He K, Wang P, Qin LQ. Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies. Am J Clin Nutr 2011;94:900–5
• 17 Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. Breast Cancer Res
Treat 2013;138(3):925-30
• 18 Wu Y, Zhang D, Kang S. Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat 2013;137(3):869-82
• 19 Scoccianti C, Key TJ, Anderson AS, et al. European code against cancer 4th edition: breast feeding and cancer. Cancer Epidemiol 2015;39(supp.1):S101-6
• 20 Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and breast feeding: a collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973
women without the disease. Lancet 2002;360(9328):187-95
• 21 Collaborative Group on Hormonal Factors in Breast Cancer. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence. Lancet
2019;394(10204):1159-68
• 22 McDonald JA, Goyal A, Terry MB. Alcohol intake and breast cancer risk: weighing the overall evidence. Curr Breast Cancer Rep 2013;5(3):10.1007/s12609-013-0114
• 23 Jones ME, Schoemaker MJ, Wright LB, Ashworth A, Swerdlow AJ. Smoking and risk of breast cancer in the Generations Study cohort. Breast Cancer Res 2017;19(1):118. doi: 10.1186/s13058-017-0908-4
• 24 Catsburg C, Miller AB, Rohan TE. Active cigarette smoking and risk of breast cancer. Int J Cancer 2015;136:2204-9
• 25 Duffy SW, Tabar L, Yen AMF, et al. Mammography screening reduces rates of advanced and fatal breast cancers: results in 549,091 women. Cancer 2020;126(13):2971-9
• 26 Division of Cancer Prevention and Control, Centers for Disease Control and Prevention. What is a mammogram? Available: https://www.cdc.gov/cancer/breast/basic_info/mammograms.htm
• 27 Arnold M, Pfeifer K, Quante AS. Is risk-stratified breast cancer screening economically efficient in Germany? PLoS One 2019;14(5):e0217213. doi: 10.1371/journal.pone.0217213
• 28 Gagnon J, Levesque E, Borduas F, et al. Recommendatations on breast cancer screening and prevention in the context of implementing risk stratification: impending changes to current policies. Cur Oncol 2016;23(6).
doi: http://dx.doi.org/10.3747/co.23.2961
Thank you
E-mail: cheachanhooi@yahoo.com
WA: 0149972321
Tel: 085329333

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Breast cancer hla

  • 1. Breast cancer Dr Chea Chan Hooi General & Laparoscopic Surgeon Borneo Medical Centre (Miri) 11th November 2020
  • 2. Content • Introduction • Basics • Risk factors • Symptoms • Investigations • Treatment • Conclusion
  • 3. Introduction • Cancer arising from breast tissue • The most common cancer in Malaysia • 1 in 20 Malaysian women will develop breast cancer in their lifetimes • 48% of patients present in stages 3 and 4, only 1/2 survive >5 years after diagnosis
  • 4. Cancer cases in Malaysia
  • 8. Risk factors • Sedentary lifestyle • Poor dietary habits high in sugar and fat besides processed meat • Obesity
  • 9. • Never had full-term pregnancy • Never breast-fed >6 months • First childbirth >35 year-old
  • 10. • Oral contraceptive pills >10 years • Post-menopausal hormone replacement therapy >4 years
  • 11. • Smoking • Excessive alcohol consumption
  • 12. • Radiotherapy to chest <30 year-old
  • 13. • Gender • Vast majority of patients are women • Men can also develop breast cancer (0.1%)
  • 15. • Age >40 years old
  • 16. • Genetics & family history of breast or ovarian cancers
  • 17. • Started menstruating <10 year-old and stopped >55 year-old
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 26.
  • 27.
  • 28.
  • 29. 0.1% of breast cancer patients are men
  • 31. • Fine needle aspiration • Obtain cells for microscopic examination • Less reliable • Biopsy • Obtain tissue sample for microscopic examination • “...diagnosed upon the basis of a microscopic examination of the fixed tissue, supported by a biopsy result.”
  • 32. • CT scan • To assess distant spread
  • 33. Treatment options • Surgery • Chemotherapy • Radiotherapy • Hormonal therapy • Targeted therapy
  • 36. Axillary (armpit) surgery Axillary dissection Sentinel lymph node biopsy
  • 37. Treatment options • Surgery • Chemotherapy • Radiotherapy • Hormonal therapy • Targeted therapy Oncologist
  • 39. Conclusion • Breast cancer is very common • Early detection saves lives • Various modalities available for early detection • Everyone associated with healthcare has a role to play to reduce its incidence
  • 40. References • 1 Worldwide cancer data global cancer statistics for the most common cancers. World Cancer Reserach Fund International. Available: https://www.wcrf.org/dietandcancer/cancer-trends/worldwide-cancer- data#:~:text=Lung%20and%20breast%20cancers%20were,million%20new%20cases%20in%202018. • 2 Azizah Ab M, Nor Saleha IT, Noor Hashimah A, Asmah ZA, Mastulu W. Malaysian National Cancer Registry Report 2007 - 2011 Malaysia cancer statistics, data & figure. National Cancer Institute, Ministry of Health Malaysia • 3 Yip CH, Nur Aishah MT, Ibraham M. Epidemiology of breast cancer in Malaysia. Asian Pac J Cancer Prev 2006;7(3):369-74. • 4 Nor Aini, Wan Rozita WM, Nor Asiah M, et al. Survival rate of breast cancer patients in Malaysia: a population-based study. Asian Pac J Cancer Prev 2013;14(8):4591-4. • 5 Cui X, Dai Q, Tseng M, et al. Dietary patterns and breast cancer risk in The Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers 2007;16:1443-8. • 6 Sun YS, Zhao Z, Yang ZN, et al. Risk factors and preventions of breast cancer. Int J Biol Sci 2017;13(11):1387-1397 • 7 Horn J, Asvold BO, Opdahl S. et al. Reproductive factors and the risk of breast cancer in old age: a Norwegian cohort study. Breast Cancer Res Treat 2013;139:237–43. • 8 Soroush A, Farshchian N, Komasi S. et al. The role of oral contraceptive pills on increased risk of breast cancer in Iranian populations: a meta-analysis. J Can Prev 2016;21:294–301. • 9L iu JY, Chen TJ, Hwang SJ. The risk of breast casncer in women using menopausal hormone replacement therapy in Taiwan. Int J Environ Res Pub Health 2016;13:482. • 10 Hamajima N, Hirose K, Tajima K, et al. Alcohol, tobacco and breast cancer-collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer 2002;87:1234–45. • 11 Brewer HR, Jones ME, Schoemaker MJ, Ashworth A, Swerdlow AJ. Family history and risk of breast cancer: an analysis accounting for family structure. Breast Cancer Rest Treat 2017;165(1):193-200. • 12 American Cancer Society. Radiation therapy for Hodgkin lymphoma. Available: https://www.cancer.org/cancer/hodgkin- lymphoma/treating/radiation.html#:~:text=Radiation%20therapy%20uses%20high%2Denergy,one%20part%20of%20the%20body. • 13 Dai Q, Shu XO, Jin F, Gao YT, Ruan ZX, Zheng W. Consumption of animal foods, cooking methods, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2002;11:801–8 • 14 Fu Z, Deming SL, Fair AM, et al. Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: the Nashville Breast Health Study. Breast Cancer Res Treat 2011;129:919–28
  • 41. • 15 Tao P, Li H, Wang Q, Cao LQ, Li JY, Yang F, Wang YP. A case-control study on association of SULT1A1 polymorphism, smoked meat intake with breast cancer risk. Zhonghua Yu Fang Yi Xue Za Zhi 2012;46:831–5 • 16 Dong JY, He K, Wang P, Qin LQ. Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies. Am J Clin Nutr 2011;94:900–5 • 17 Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. Breast Cancer Res Treat 2013;138(3):925-30 • 18 Wu Y, Zhang D, Kang S. Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat 2013;137(3):869-82 • 19 Scoccianti C, Key TJ, Anderson AS, et al. European code against cancer 4th edition: breast feeding and cancer. Cancer Epidemiol 2015;39(supp.1):S101-6 • 20 Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and breast feeding: a collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet 2002;360(9328):187-95 • 21 Collaborative Group on Hormonal Factors in Breast Cancer. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence. Lancet 2019;394(10204):1159-68 • 22 McDonald JA, Goyal A, Terry MB. Alcohol intake and breast cancer risk: weighing the overall evidence. Curr Breast Cancer Rep 2013;5(3):10.1007/s12609-013-0114 • 23 Jones ME, Schoemaker MJ, Wright LB, Ashworth A, Swerdlow AJ. Smoking and risk of breast cancer in the Generations Study cohort. Breast Cancer Res 2017;19(1):118. doi: 10.1186/s13058-017-0908-4 • 24 Catsburg C, Miller AB, Rohan TE. Active cigarette smoking and risk of breast cancer. Int J Cancer 2015;136:2204-9 • 25 Duffy SW, Tabar L, Yen AMF, et al. Mammography screening reduces rates of advanced and fatal breast cancers: results in 549,091 women. Cancer 2020;126(13):2971-9 • 26 Division of Cancer Prevention and Control, Centers for Disease Control and Prevention. What is a mammogram? Available: https://www.cdc.gov/cancer/breast/basic_info/mammograms.htm • 27 Arnold M, Pfeifer K, Quante AS. Is risk-stratified breast cancer screening economically efficient in Germany? PLoS One 2019;14(5):e0217213. doi: 10.1371/journal.pone.0217213 • 28 Gagnon J, Levesque E, Borduas F, et al. Recommendatations on breast cancer screening and prevention in the context of implementing risk stratification: impending changes to current policies. Cur Oncol 2016;23(6). doi: http://dx.doi.org/10.3747/co.23.2961
  • 42. Thank you E-mail: cheachanhooi@yahoo.com WA: 0149972321 Tel: 085329333