2. Alzheimer's disease
Alzheimer's disease is a progressive
neurologic disorder that causes the brain
to shrink, loss function and brain cells to
die.
Destroys neurons and there connections
In entorhinal cortex and hippocampus .
Low level of certain neurotransmitters.
It later affects the other area’s in the
cerebral cortex.
The disease is fatal.
3. Symptoms
Memory loss .
Thinking and reasoning
Making judgments and decisions
Planning and performing familiar tasks
4. Etiology
The amyloid cascade hypothesis says that deposition of
amyloid β protein (AβP) is the main component of the
plaques(amyloid plaques), is the causative agent of
Alzheimer’s pathology and that the neurofibrillary tangles,
cell loss, vascular damage, and dementia follow as a direct
result of this deposition.
A common counter-argument to the amyloid hypothesis is
that plaques are found in the brains of many elderly
people with normal cognition. It has been consistently
shown that Aβ accumulation and deposition do not correlate
with neuronal loss and cognitive decline
Tau tangles – Tau is a microtubule-associated tubule that
stabilizes neuronal microtubules but in AD it forms insoluble
filaments that accumulate as neurofibrillary tangles .
