Geliştirdiğimiz Fonksiyonel Zeytinyağı 2014 yılında Dünya Fonksiyonel Gıda Kongresi'nde yayın olarak paylaşılmış ve oldukça ilgi görmüştü.

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Olive Oil (100 gr) Functional Olive Oil (100 gr)
ppm
Oleuropein Amount in Olive Oils
Curcumin and Oleuropein Enriched Extra Virgin Olive Oil
as a Functional Food and Nutraceutical
Ihsan KARA1, Can KAYACILAR2.
1Istanbul Biotechnology and Laboratory Services Limited Company, Istanbul/Turkey.
2Nanoyasam Nanobiotechnology R&D Industry and Trade Limited Company, Istanbul /Turkey.
Oleuropein Standard (500 ppm)
Extra Virgin Olive Oil (Curcumin)
Functional Olive Oil (Curcumin)
Curcumin Standard
Extra Virgin Olive Oil (Oleuropein)
Functional Olive Oil (Oleuropein)
Samples Area ppm
Olive Oil (100 gr) 238389,1 47,15
Functional Olive Oil (100 gr) 1098410 181,14
Olive Leaves (1 gr) 24706556,1 3859,28
280 nm
Retention time= 39,6
References
Ahmad-Qasem MH, Cánovas J, Barrajón-Catalán E, Carreres JE, Micol V, García-Pérez JV. Influence of olive leaf processing on the bioaccessibility of bioactive polyphenols. J Agric Food
Chem. 2014 Jul 2;62(26):6190-8.
Andreadou, Ioanna; Iliodromitis, Efstathios K.; Mikros, Emmanuel; Constantinou, Maria; Agalias, Apostolos; Magiatis, Prokopios; Skaltsounis, Alexios Leandros; Kamber, Elli et al.
(2006). "The Olive Constituent Oleuropein Exhibits Anti-Ischemic, Antioxidative, and Hypolipidemic Effects in Anesthetized Rabbits". The Journal of Nutrition 136 (8): 2213–9.
Bulotta S, Celano M, Lepore SM, Montalcini T, Pujia A, Russo D. Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against
cardiovascular and metabolic diseases. J Transl Med. 2014 Aug 3;12:219.
Hassan ZK, Elamin MH, Omer SA, Daghestani MH, Al-Olayan ES, Elobeid MA, Virk P. Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pac J Cancer Prev.
2013;14(11):6739-42.
Hsieh YW, Huang CY, Yang SY, Peng YH, Yu CP, Chao PD, Hou YC. Oral intake of curcumin markedly activated CYP 3A4: in vivo and ex-vivo studies. Sci Rep. 2014 Oct 10;4:6587.
Janahmadi Z, Nekooeian AA, Moaref AR, Emamghoreishi M. Oleuropein Offers Cardioprotection in Rats with Acute Myocardial Infarction. Cardiovasc Toxicol. 2014 Aug 13.
Lee WH, Loo CY, Young PM, Traini D, Mason RS, Rohanizadeh R. Recent advances in curcumin nanoformulation for cancer therapy. Expert Opin Drug Deliv. 2014 Aug;11(8):1183-201.
Luccarini I, Ed Dami T, Grossi C, Rigacci S, Stefani M, Casamenti F. Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain. Neurosci Lett. 2014 Jan 13;558:67-72.
Rahmani AH, Al Zohairy MA, Aly SM, Khan MA. Curcumin: A Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways. Biomed Res Int. 2014;2014:761608.
Sarbishegi M, Mehraein F, Soleimani M. Antioxidant role of oleuropein on midbrain and dopaminergic neurons of substantia nigra in aged rats. Iran Biomed J. 2014;18(1):16-22.
Son S, Kim KT, Cho DC, Kim HJ, Sung JK, Bae JS. Curcumin Stimulates Proliferation of Spinal Cord Neural Progenitor Cells via a Mitogen-Activated Protein Kinase Signaling Pathway. J
Korean Neurosurg Soc. 2014 Jul;56(1):1-4.
Svobodova M, Andreadou I, Skaltsounis AL, Kopecky J, Flachs P. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376.
Tripoli, Elisa; Giammanco, Marco; Tabacchi, Garden; Di Majo, Danila; Giammanco, Santo; La Guardia, Maurizio (2009). "The phenolic compounds of olive oil: Structure, biological activity and
beneficial effects on human health". Nutrition Research Reviews 18 (1): 98–112.
Virruso C, Accardi G, Colonna-Romano G, Candore G, Vasto S, Caruso C. Nutraceutical properties of extra-virgin olive oil: a natural remedy for age-related disease? Rejuvenation Res. 2014
Apr;17(2):217-20.
Functional Olive Oil is an Effective Protector of Our Health
The term “functional food” defines foods that have some benefits to health along
with nutrients. Another words; they are defined as foods and food ingredients that
beyond providing body’s main nutritional requirements, provide additional
benefits to human physiology and metabolic functions and by this way provide
protection against diseases and help achieving more healthier life. Aside from
nutritive effects, depending on one or more effective ingredients, foods that have
properties like having protective, regenerative effects on health and/or provide
reduced risk of getting sick, and if these properties are proved both scientifically
and clinically, are known as functional food. Sufficient amount of presence of
these functional foods in our nutrition is important in terms of their detractive
effects over risk of getting chronic diseases leading with cancer, cardiovascular
diseases, obesity, Alzheimer’s disease and Type 2 diabetes.
Functional Olive Oil, is the olive oil that we use in our daily lives which is
enriched by different antioxidants that have beneficial effects on our health. Olive
oil that enriched by curcumin and oleuropein antioxidants at the position of
protector of our general health because of containing molecules that have so many
beneficial effects on our health.
Functional Olive Oil that we developed by using advanced
technology basically contains antioxidants like oleuropein,
hydroxyl trisol, curcumin which are scientifically proved that
have beneficial effects on our health. Scientific studies made
by using oleuropein and curcumin molecules, discovered that
these molecules are not only strong antioxidants, protective
against cancer and destroyer of cancerous cells; and have
anti-inflammatory, anti-atherosclerotic, antimicrobial and
antiviral affects; but they also discovered to have anti-aging,
anti-neurodegenerative nature. The amount of Oleuropein
molecule, which can have enormous contributions for
protecting of our health, is not more than 5 mg/liters in any
high quality olive oil. One of the main reasons of this
situation is that the amount of these molecule in the leaves of
the olive trees is higher than in olives.
In functional olive oil that we developed,
oleuropein molecule is extracted from olive leaves
by using advanced technologies and purified and
then added to the olive oil. By this way, the
functional olive oil that we produced contains
approximately 10 times more (50-60 mg/lt)
bioactive ingredient when compared to any high
quality olive oil. An olive oil with this quality is
not yet present in the market. Besides with the
addition of curcumin to olive oil, it is estimated
that the high proportion of our society will benefit
from the health protective properties of curcumin.